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Linkage Analysis in Familial Dysautonomia Using Variations in DNA Sequence in the β-Nerve Growth Factor Gene Region: A Beginning

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Cellular and Molecular Biology of Neuronal Development

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Abstract

The availability of cloned human DNA sequences combined with classic methods of genetic linkage analysis allows us to establish whether a mutation in a given gene produces an inherited disease state. In this chapter, we will describe how cloned DNA probes corresponding to the human gene for β-nerve growth factor (βNGF) can be used to determine whether an alteration in the structure or expression of this gene is the primary defect in the inherited neurological disease familial dysautonomia. Our preliminary findings are also presented.

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Author information

Authors and Affiliations

  1. Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut, USA

    Xandra O. Breakefield & Carmela M. Castiglione

  2. Department of Molecular Biology, Genentech, Inc, South San Francisco, California, 94080, USA

    Lisa M. Coussens & Axel Ullrich

  3. Department of Pediatrics, New York University Medical Center, New York, New York, 10016, USA

    Felicia B. Axelrod

Authors
  1. Xandra O. Breakefield
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  2. Carmela M. Castiglione
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  3. Lisa M. Coussens
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  4. Felicia B. Axelrod
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  5. Axel Ullrich
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Editor information

Editors and Affiliations

  1. Cornell University Medical College, New York, New York, USA

    Ira B. Black

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© 1984 Plenum Press, New York

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Breakefield, X.O., Castiglione, C.M., Coussens, L.M., Axelrod, F.B., Ullrich, A. (1984). Linkage Analysis in Familial Dysautonomia Using Variations in DNA Sequence in the β-Nerve Growth Factor Gene Region: A Beginning. In: Black, I.B. (eds) Cellular and Molecular Biology of Neuronal Development. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2717-2_20

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  • DOI: https://doi.org/10.1007/978-1-4613-2717-2_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9686-7

  • Online ISBN: 978-1-4613-2717-2

  • eBook Packages: Springer Book Archive

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