Skip to main content

Expression of Opioid Peptide Genes in Different Species

  • Chapter
Cellular and Molecular Biology of Neuronal Development
  • 73 Accesses

Abstract

In the past 15 years, a number of small peptides that mediate specific kinds of behavior have been isolated. For example, hypothalamic releasing factors ranging from 3 to 41 amino acids in length regulate the production and release of anterior pituitary hormones that mediate growth, reproductive cycles, and diurnal light and temperature cycles. Substance P and opioid peptides regulate the perception of pain in the animal by serving as neurotransmitters and neuromodulators in the nervous system. Other peptides have been implicated in regulating sleep and temperature (bombesin). The train of responses involved in egg-laying behavior in Aplysia has been shown to be triggered by a small group of related peptides. Finally, peptide pheromones (a and α factors) mediate the union of yeast cells during conjugation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bradbury, A.F., Smyth, D.G., Snell, C.R., Birdsall, N.J.M., and Hulme, E.C., 1976, C fragment of lipotropin has a high affinity for brain opiate receptors, Nature (London), 260: 793 – 795.

    Article  CAS  Google Scholar 

  • Chang, A.C.Y., Cochet, M., and Cohen, S.N., 1980, Structural organization of human genomic DNA encoding the pro-opiomelanocortin peptide, Proc. Natl. Acad. Sci. U.S.A. 77: 4890 – 4894.

    Article  PubMed  CAS  Google Scholar 

  • Cochet, M., Chang, A.C.Y., and Cohen, S.N., 1982, Characterization of the structural gene and putative 51 regulatory sequences for human pro-opiomelanocortin, Nature, 297: 335 – 339

    Article  PubMed  CAS  Google Scholar 

  • Comb, M., Seeburg, P., Adelman, J., Eiden, L., and Herbert, E., 1982, Primary structure of the human Met- and Leu-enkephalin precursor and its mRNA, Nature (London), 295: 663 – 666.

    Article  CAS  Google Scholar 

  • Comb, M., Rosen, H., and Herbert, E., 1983, Structure of the human pro-enkephalin gene: Clustering of CPG sequences and relationship to methylation, J. DNA, 2(3): 278 – 290.

    Google Scholar 

  • Cone, R.I., and Goldstein, A., 1982, A dynorphin like opioid in the central nervous system of an amphibian, Proc. Natl. Acad. Sci. U.S.A. 79: 3345 – 3349.

    Article  PubMed  CAS  Google Scholar 

  • Felsenfeld, G., and McGhee, J., 1982, Methylation and gene control, Nature (London), 296: 602 – 605.

    Article  CAS  Google Scholar 

  • Goldstein, A., Tachibana, S., Lowney, L.I., Hunkapillar, M., and Hood, L., 1979, Dynorphin (1–13), an extraordinarily potent opioid peptide, Proc. Natl. Acad. Sci. U.S.A. 76: 6666 – 6670.

    Article  PubMed  CAS  Google Scholar 

  • Goldstein, A., Fischli, W., Lowney, L.I., Hunkapillar, M., and Hood, L., 1981, Porcine pituitary dynorphin: Complete amino acid sequence of the biologically active heptadecapeptide, Proc. Natl. Acad. Sci. U.S.A. 78: 7219 – 7223.

    Article  PubMed  CAS  Google Scholar 

  • Gubler, U., Seeburg, P., Hoffman, B.J., Gage, L.P., and Udenfriend, S., 1982, Molecular cloning establishes proenkephalin as precursor of enkephalin-containing peptides, Nature (London), 295: 206 – 208.

    Article  CAS  Google Scholar 

  • Herbert, E., Birnberg, N., Lissitsky, J-C., Civelli, O., and Uhler, M., 1981, Pro-opiomelanocortin: A model for regulation of expression of neuropeptides in pituitary and brain, Neurosci. Newslett. 12: 16 – 27.

    Google Scholar 

  • Hoffman, W., Bach, T.C., Seliger, H., and Kreil, G., 1983, Biosynthesis of caerulein in the skin of Xenopus laevis: Partial sequences of precursors as deduced from cDNA clones, Eur. Mol. Biol. Assoc. J. 2(1): 111—114.

    Google Scholar 

  • Hughes, J., Smith, J.W., Kosterlitz, H.W., Forthgill, L.A., Morgan, B.A., and Morris, H.R., 1975, Identification of two related pentapeptides from brain with potent opioid agonist activity, Nature, 258: 557 – 579.

    Article  Google Scholar 

  • Kakidani, H., Furutani, Y., Takahashi, H., Noda, M., Morimoto, Y., Hirose, T., Asai, M., Inayama, S., Nakanishi, S., and Numa, S., 1982, Cloning and sequence analysis of cDNA for porcine β-neo-endorphin/dynorphin precursors, Nature (London), 298: 245 – 249.

    Article  CAS  Google Scholar 

  • Kilpatrick, D.L., Takashi, T., Jones, B.N., Stern, A.S., Shively, J.E., Hullihan, J., Kimura, S., Stein, S., and Udenfriend, S., 1981, A highly potent 3200-dalton adrenal opiate that contains both a Met- and Leu-enkephalin sequence, Proc. Natl. Acad. Sci. U.S.A. 78: 3265 – 3268.

    Article  PubMed  CAS  Google Scholar 

  • Kurjan, J., and Herskowitz, I., 1982, Structure of a yeast pheromone gene (MFα): a putative α- factor precursor containing four tandem copies of mature α factor, Cell, 30: 933 – 943.

    Article  PubMed  CAS  Google Scholar 

  • Land, H., Schiitz, G., Schmale, H., and Richter, D., 1982, Nucleotide sequence of clones cDNA encoding the bovine arginine vaso-pressin-neurophysin II precursor, Nature (London) 295: 299 – 303.

    Article  CAS  Google Scholar 

  • LeRoith, D., Liotta, A.S., Roth, J., Shiloach, J., Lewis, M.E., Pert, C.B., and Krieger, D.T., 1982, Corticotropin and β-endorphin like materials are native to unicellular organisms, Proc. Natl. Acad. Sci. U.S.A. 79: 2086 – 2090.

    Article  PubMed  CAS  Google Scholar 

  • Li, C.H., and Chung, D., 1976, Isolation and structure of an untriakontapeptide with opiate activity from camel pituitary glands, Proc. Natl. Acad. Sci. U.S.A. 73: 1145 – 1148.

    Article  PubMed  CAS  Google Scholar 

  • Mains, R.E., Eipper, B.A., and Ling, N., 1977, Common precursor to corticotropins and endotropins, Proc. Natl. Acad. Sci. U.S.A. 74: 3014 – 3018.

    Article  PubMed  CAS  Google Scholar 

  • Nakanishi, S., Inoue, A., Kita, J., Kakamura, M., Chang, A.C.Y., Cohen, S.N., and Numa, S., 1979, Nucleotide sequence of cloned cDNA for bovine corticotropin -P- lipotropin precursor, Nature, 278: 423 – 427.

    Article  PubMed  CAS  Google Scholar 

  • Noda, M., Furutani, Y., Takahashi, H., Toyosato, M., Hirose, T., Inayama, S., Nakanishi, S., and Numa, S., 1982, Cloning and sequence analysis of cDNA for bovine adrenal preproenkephalin, Nature (London), 295: 202 – 206.

    Article  CAS  Google Scholar 

  • Owerbach, D., Rutter, W.J., Roberts, J.L., Whitfeld, P., Shine, J., Seeburg, P.H., and Shows, T.B., 1981, The proopiocortin (adrenocorticotropin/β-lipotropin) gene is located on chromosome 2 in humans, Somat. Cell Genet. 7: 359 – 369.

    Article  PubMed  CAS  Google Scholar 

  • Pedersen, R.C., and Brownie, A.C., 1980, Adrenocortical response to corticotropin is potentiated by a part of the N-terminal region of pro-corticotropin/endorphin, Proc. Natl. Acad. Sci. U.S.A. 77: 2239 – 2243.

    Article  PubMed  CAS  Google Scholar 

  • Roberts, J.E., and Herbert, E., 1977, Characterization of a common precursor to corticotropin and β-lipotropin: identification of β-lipotropin peptides and their arrangement relative to corticotropin, Proc. Natl. Acad. Sci. U.S.A. 74: 5300 – 5304.

    Article  PubMed  CAS  Google Scholar 

  • Scheller, R.H., Jackson, J.F., McAllister, L.B., Rothman, B.S., Mayeri, E., and Axel, R., 1983, A single gene encodes multiple neuropeptides mediating a steroetyped behavior, Cell. 32: 7 – 22.

    Article  PubMed  CAS  Google Scholar 

  • Uhler, M., and Herbert, E., D’Eustachio, P., and Ruddle, F.O., 1983, The mouse genome contains two non-allellic proopiomelanocortin genes, J. Biol. Chem. 258: 9444 – 9453.

    PubMed  CAS  Google Scholar 

  • Whitfeld, P.L., Seeburg, P.H., and Shine, J., 1982, The human pro-opiomelanocortin gene: Organization, sequence and interspersion with repetitive DNA, J. DNA, 1: 133 – 144.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Plenum Press, New York

About this chapter

Cite this chapter

Herbert, E., Comb, M., Rosen, H., Martens, G. (1984). Expression of Opioid Peptide Genes in Different Species. In: Black, I.B. (eds) Cellular and Molecular Biology of Neuronal Development. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2717-2_18

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2717-2_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9686-7

  • Online ISBN: 978-1-4613-2717-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics