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Trophic and Neurite-Promoting Factors for Cholinergic Neurons

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Cellular and Molecular Biology of Neuronal Development

Abstract

The term neuronotrophic factor (NTF) designates a biological macromolecule that is required for the maintenance and general growth capabilities of selected nerve cells (Varon, 1977; Varon and Adler, 1980). The prototype for such factors has been nerve growth factor (NGF), a protein discovered some 30 years ago that acts both in vivo and in vitro on sensory and sympathetic peripheral neurons (e.g., Levi-Montalcini and Angeletti 1968; Varon, 1975a; Green and Shooter, 1980; Thoenen and Barde, 1980; Varon and Skaper, 1983a,b). Virtually all the NGF studies have relied on the use of tissue-culture techniques for the quantitative measure and monitoring of its biological activities.

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Authors and Affiliations

  1. Department of Biology, School of Medicine, University of California, San Diego, La Jolla, California, 92093, USA

    Silvio Varon & Marston Manthorpe

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  1. Silvio Varon
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  2. Marston Manthorpe
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  1. Cornell University Medical College, New York, New York, USA

    Ira B. Black

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© 1984 Plenum Press, New York

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Varon, S., Manthorpe, M. (1984). Trophic and Neurite-Promoting Factors for Cholinergic Neurons. In: Black, I.B. (eds) Cellular and Molecular Biology of Neuronal Development. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2717-2_17

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  • DOI: https://doi.org/10.1007/978-1-4613-2717-2_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9686-7

  • Online ISBN: 978-1-4613-2717-2

  • eBook Packages: Springer Book Archive

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