Advertisement

Macromolecular Factors Involved in the Regulation of the Survival and Differentiation of Peripheral Sensory and Sympathetic Neurons

  • Hans Thoenen
  • Yves-Alain Barde
  • David Edgar

Abstract

Neuronal cell death is a widespread physiological phenomenon that occurs during development of vertebrate peripheral and central nervous systems (Cowan, 1973; Jacobson, 1978). The topographically selective regulation of the structure and function of the fully differentiated nervous system, and there is evidence that a major mechanism responsible involves the local production and release of trophic factors (see Barde et al., 1983).

Keywords

Nerve Growth Factor Neurotrophic Factor Trophic Factor Sympathetic Neuron Nerve Growth Factor Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Adler, R., Manthorpe, M., Skaper, S.D., and Varon, S., 1981, Polyornithine neurite-promoting factors, Brain Res. 206: 129 – 144.PubMedCrossRefGoogle Scholar
  2. Barde, Y.-A., Lindsay, R.M., Monard, D., and Thoenen, H., 1978, New growth factor released by glioma cells supporting survival and growth of sensory neurones, Nature (London) 274: 818.CrossRefGoogle Scholar
  3. Barde, Y.-A., Edgar, D., and Thoenen, H., 1980, Sensory neurons in culture: Changing requirements for survival factors during embryonic development, Proc. Natl. Acad. Sci. U.S.A. 77: 1199 – 1203.PubMedCrossRefGoogle Scholar
  4. Barde, Y.-A., Edgar, D., and Thoenen, H., 1982a, Purification of a new neurotrophic factor from mammalian brain, EMBO J. 1: 549 – 553.PubMedGoogle Scholar
  5. Barde, Y.-A., Edgar, D., and Thoenen, H., 1982b, Molecules involved in the regulation of neuron survival during development, in: Neuroscience Approached through Cell Culture, Vol. 1 ( S. Pfeiffer, ed.), CRC Press, Boca Raton, Florida, pp. 69 – 86.Google Scholar
  6. Barde, Y.-A., Edgar, D., and Thoenen, H., 1983, New neurotrophic factors, Annu. Rev. Physiol. 45: 601 – 612.PubMedCrossRefGoogle Scholar
  7. Burnstock, G., 1974, Degeneration and orientation of growth of autonomic nerves in relation to smooth muscle in joint tissue cultures and anterior eye chamber transplants, in: Dynamics of Degeneration and Growth in Neurons( K. Fuxe, L. Olson, and Y. Zollerman, eds.), Pergamon Press, Oxford, pp. 509 – 520.Google Scholar
  8. Chang, J.-Y., 1981, N-terminal sequence analysis of polypeptide at the picomole level, Biochem. J. 199: 557 – 564.PubMedGoogle Scholar
  9. Cohen, S., 1960, Purification of a nerve-growth promoting protein from the mouse salivary gland and its neurocytotoxic antiserum, Proc. Natl. Acad. Sci. U.S.A. 46: 302 – 311.PubMedCrossRefGoogle Scholar
  10. Collins, F., 1978, Induction of neurite outgrowth by a conditioned-medium factor bound to the culture substratum, Proc. Natl. Acad. Sci. U.S.A. 75: 5210 – 5213.PubMedCrossRefGoogle Scholar
  11. Cowan, W.M., 1973, Neuronal death as a regulative mechanism in the control of cell number in the nervous system, in: Development and Aging in the Nervous System( M. Rockstein, ed.), Academic Press, New York, pp. 19 – 41.Google Scholar
  12. Devos, R., Cheroutre, H., Taya, Y., Degrave, W., Van Heuverswyn, H., and Fiers, W., 1982, Molecular cloning of human immune interferon cDNA and its expression in eukaryotic cells, Nucleic Acids Res. 10: 2487 – 2501.PubMedCrossRefGoogle Scholar
  13. Ebendal, T., and Jacobson, C.O., 1977, Tissue explants affecting extension and orientation of axons in cultured chick embryo ganglia, Exp. Cell Res. 105: 379 – 387.PubMedCrossRefGoogle Scholar
  14. Edgar, D., and Thoenen, H., 1982, Modulation of NGF-induced survival of chick sympathetic neurons by contact with a conditioned medium factor bound to the culture substrate, Dev. Brain Res. 5: 89 – 92.CrossRefGoogle Scholar
  15. Gluzman, Y., 1982, Eukaryotic Viral Vectors, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.Google Scholar
  16. Harper, G.P., and Thoenen, H., 1981, Target cells, biological effects and mechanism of action of nerve growth factor and its antibodies, Annu. Rev. Pharmacol. Toxicol. 21: 205 – 229.PubMedCrossRefGoogle Scholar
  17. Harper, G.P., Pearce, F.L., and Vernon, C.A., 1980, The production and storage of nerve growth factor in vivo by tissues of the mouse, rat, guinea pig, hamster and gerbil, Dev. Biol. 34: 893 – 903.Google Scholar
  18. Harper, G.P., Glanville, R.W., and Thoenen, H., 1982, The purification of nerve growth factor from bovine seminal plasma, J. Biol. Chem. 257: 8541 – 8548.PubMedGoogle Scholar
  19. Hood, L., Hunkapiller, M., and Dreyer, W.J., 1981, Microchemical instrumentation: ICN-UCLA Symposium on Cellular Recognition, J. Supramol. Struct. Cell Biochem. 17: 27 – 36.PubMedCrossRefGoogle Scholar
  20. Jacobson, M. (ed.), 1978, Developmental Neurobiology, 2nd ed., Plenum Press, New York.Google Scholar
  21. Kohler, G., and Milstein, C., 1976, Derivation of specific antibody-producing tissue culture and tumor lines by cell fusion, Eur. J. Immunol. 6: 511 – 519.PubMedCrossRefGoogle Scholar
  22. Korsching, S., and Thoenen, H., 1983, Levels of nerve growth factor in sympathetic ganglia and corresponding target organs of the rat: Correlation with the density of sympathetic innervation, Proc. Natl. Acad. Sci. U.S.A. 80: 3513 – 3516.PubMedCrossRefGoogle Scholar
  23. Levi-Montalcini, R., 1966, The nerve growth factor: Its mode of action on sensory and sympathetic nerve cells, Harvey Lect. 60: 217 – 259.PubMedGoogle Scholar
  24. Lomedico, P.T., 1982, Use of recombinant DNA technology to program eukaryotic cells to synthesize rat proinsulin: A rapid expression assay for cloned genes, Proc. Natl. Acad. Sci. U.S.A. 79: 5798 – 5802.PubMedCrossRefGoogle Scholar
  25. Luben, R.A., Brazeau, P., Bohlen, P., and Guillemin, R., 1982, Monoclonal antibodies to hypothalamic growth hormone-releasing factor with picomoles of antigen, Science, 218: 887 – 889.PubMedCrossRefGoogle Scholar
  26. Noyes, B.E., Mevarech, N., Stein, R., and Agarwal, K.L., 1979, Detection and partial sequence analysis of gastrin mRNA by using an oligodeoxynucleotide probe, Proc. Natl. Acad. Sci. U.S.A. 76: 1770 – 1774.PubMedCrossRefGoogle Scholar
  27. Schmitt, F.O., Bird, S.J., and Bloom, F.E. (eds.), 1982, Molecular Genetic Neuroscience, Neurosciences Research Program, Raven Press, New York.Google Scholar
  28. Stetler, D., Das, H., Nunberg, J.H., Saiki, R., Sheng-Dong, R., Mullis, K.B., Weissman, S.H., and Erlich, H.A., 1982, Isolation of a cDNA clone for the human HLA-DR antigen chain by using a synthetic oligonucleotide as hybridization probe, Proc. Natl. Acad. Sci. U.S.A. 79: 5966 – 5970.PubMedCrossRefGoogle Scholar
  29. Thoenen, H., and Barde, Y.-A., 1980, Physiology of nerve growth factor, Physiol. Rev. 60: 1284 – 1335.PubMedGoogle Scholar
  30. Wakade, A.R., Edgar, D., and Thoenen, H., 1983, Both nerve growth factor and high K+ concentrations support the survival of chick embryo sympathetic neurons: Evidence for a common mechanism of action, Exp. Cell Res. 144: 377 – 384.PubMedCrossRefGoogle Scholar
  31. Wakade, A.R., Edgar, D., and Thoenen, H., 1983, Both nerve growth factor and high K+ concentrations support the survival of chick embryo sympathetic neurons: Evidence for a common mechanism of action, Exp. Cell Res. 144: 377 – 384.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Hans Thoenen
    • 1
  • Yves-Alain Barde
    • 1
  • David Edgar
    • 1
  1. 1.Department of NeurochemistryMax-Planck-Institute for PsychiatryMartinsriedFederal Republic of Germany

Personalised recommendations