Macromolecular Factors Involved in the Regulation of the Survival and Differentiation of Peripheral Sensory and Sympathetic Neurons

  • Hans Thoenen
  • Yves-Alain Barde
  • David Edgar


Neuronal cell death is a widespread physiological phenomenon that occurs during development of vertebrate peripheral and central nervous systems (Cowan, 1973; Jacobson, 1978). The topographically selective regulation of the structure and function of the fully differentiated nervous system, and there is evidence that a major mechanism responsible involves the local production and release of trophic factors (see Barde et al., 1983).


Nerve Growth Factor Neurotrophic Factor Trophic Factor Sympathetic Neuron Nerve Growth Factor Level 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Hans Thoenen
    • 1
  • Yves-Alain Barde
    • 1
  • David Edgar
    • 1
  1. 1.Department of NeurochemistryMax-Planck-Institute for PsychiatryMartinsriedFederal Republic of Germany

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