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Subcellular Biochemistry pp 281–357Cite as

Nucleocytoplasmic RNA Transport

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Abstract

During the past decade, it has become evident that, in eukaryotes, RNA molecules undergo a complex series of chemical modifications after transcription and before translation and that some of these modifications coincide with alterations in subcellular distribution. There is growing evidence that these posttranscriptional events, both at the level of the RNA molecule (“processing”) and at the whole-cell level (“transport”), are of great biological importance. Posttranscriptional RNA processing has been thoroughly and frequently reviewed over the past few years, and (although many controversies remain to be resolved) a coherent body of thought has existed in the field at least since publication of the review by Perry (1976). However, RNA transport, the cellbiological counterpart of processing, has been much less thoroughly reviewed, and despite the steady accumulation of experimental data, the field lacks a coherent body of thought. The review by Webb et al. (1981) is comprehensive and argues cogently for a special messenger RNA (mRNA) transport mechanism, susceptible to regulating influences including hormones, and for abnormalities at the locus of RNA transport in a number of pathological conditions. As the first complete survey of the field, however, it offers no general hypothesis about mechanism. An article on the cytoplasmic regulation of eukaryotic gene expression by Lichtenstein et al. (1981) contains much that is relevant to RNA transport, but, being concerned with the assessment of an interesting speculative model, does not address itself critically to the experimental basis of the data to which it refers.

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References

  • Aaronson, R. P., and Blobel, G., 1974, On the attachment of the pore complex, J. Cell Biol 62: 746–754.

    Article  PubMed  CAS  Google Scholar 

  • Aaronson, R. P., and Blobel, G., 1975, Isolation of nuclear pore complexes in association with a lamina, Proc. Natl. Acad. Sci. U.S.A 72: 1007–1011.

    Article  PubMed  CAS  Google Scholar 

  • Aaronson, R. P., Coruzzi, L. A., and Schmidt, K., 1982, Nuclear pore complexes: Status of isolation attempts, in: The Nuclear Envelope and the Nuclear Matrix (G. G. Maul, ed.), pp. 13–30, Wistar Symposium Series, Vol. 2, Alan R. Liss, New York.

    Google Scholar 

  • Agutter, P. S., 1980, Influence of nucleotides, cations and nucleoside triphosphatase inhibitors on the release of ribonucleic acid from isolated rat liver nuclei, Biochem. J 188: 91–97.

    PubMed  CAS  Google Scholar 

  • Agutter, P. S., 1982, Comparison of methods for studying RNA efflux from isolated nuclei, in: The Nuclear Envelope and the Nuclear Matrix (G. G. Maul, ed.), pp. 91–110, Wistar Symposium Series, Vol. 2, Alan R. Liss, New York.

    Google Scholar 

  • Agutter, P. S., 1983, An assessment of some methodological criticisms of studies of RNA efflux from isolated nuclei, Biochem. J 214: 915–921.

    PubMed  CAS  Google Scholar 

  • Agutter, P. S., and Birchall, K., 1979, Functional differences between mammalian nuclear matrix and pore-lamina preparations, Exp. Cell Res. 124: 453–460.

    Article  PubMed  CAS  Google Scholar 

  • Agutter, P. S., and Gleed, C. D., 1980, Variability of mammalian liver nuclear envelope preparations, Biochem. J 192: 85–89.

    PubMed  CAS  Google Scholar 

  • Agutter, P. S., and McCaldin, B., 1979, Inhibition of ribonucleic acid efflux from isolated SV40-3T3 cell nuclei by 3’-deoxy-adenosine (cordycepin), Biochem. J 180: 371–378.

    PubMed  CAS  Google Scholar 

  • Agutter, P. S., and Ramsay, I., 1979, Further studies on the stimulation of the nuclear envelope nucleoside triphosphatase by polyguanylic acid, Biochem. Soc. Trans 7: 720–721.

    CAS  Google Scholar 

  • Agutter, P. S., and Richardson, J. C. W., 1980, Nuclear nonchromatin proteinaceous structures: Their role in the organization and function of the interphase nucleus, J. Cell Sci 44: 395–435.

    PubMed  CAS  Google Scholar 

  • Agutter, P. S., and Suckling, K. E., 1981, Effects of cholesterol on the properties of the membranes of isolated sheep liver nuclei and nuclear envelopes, Biochim. Biophys. Acta 643: 182–190.

    Article  PubMed  CAS  Google Scholar 

  • Agutter, P. S., and Suckling, K. E., 1982a, The fluidity of the nuclear envelope lipid does not affect the rate of nucleocytoplasmic RNA transport in mammalian liver, Biochim. Biophys. Acta 696: 308–314.

    CAS  Google Scholar 

  • Agutter, P. S., and Suckling, K. E., 1982b, Effect of colchicine on mammalian liver nuclear envelope and on nucleo-cytoplasmic RNA transport, Biochim. Biophys. Acta 698: 223–229.

    CAS  Google Scholar 

  • Agutter, P. S., McArdle, H. J., and McCaldin, B., 1976, Evidence for involvement of nuclear envelope nucleoside triphosphatase in nucleocytoplasmic translocation of ribonucleoprotein, Nature (London) 263: 165–167.

    Article  CAS  Google Scholar 

  • Agutter, P. S., Harris, J. R., and Stevenson, I., 1977, RNA stimulation of mammalian liver nuclear envelope nucleoside triphosphatase: A possible enzymic marker for the nuclear envelope, Biochem. J 162: 671–679.

    PubMed  CAS  Google Scholar 

  • Agutter, P. S., Birchall, K., Clark, J. E., Hotson, J. A., and Porteous, E. R., 1978, Nuclear envelopes and pore-laminae from a variety of mammalian tissues, Biochem. Soc. Trans 6: 1177–1179.

    PubMed  CAS  Google Scholar 

  • Agutter, P. S., Cockrill, J. B., Lavine, J. E., McCaldin, B., and Sim, R. B., 1979a, Properties of mammalian nuclear envelope nucleoside triphosphatase, Biochem. J 181: 647–658.

    CAS  Google Scholar 

  • Agutter, P. S., McCaldin, B., and McArdle, H. J., 1979b, Importance of nuclear envelope nucleoside triphosphatase in nucleo-cytoplasmic RNA transport, Biochem. J 182: 811–819.

    CAS  Google Scholar 

  • Ahmed, K., and Steer, R. C., 1982, Protein kinase and phosphatase reactions of the nuclear envelope, in: The Nuclear Envelope and the Nuclear Matrix (G. G. Maul, ed.), pp. 31–46, Wistar Symposium Series, Vol. 2, Alan R. Liss, New York.

    Google Scholar 

  • Albrecht, C. F., 1974, Informofers in rat liver and DAB-1 hepatoma, S. Afr. J. Sci 70: 86.

    Google Scholar 

  • Alesenko, A. V., Boikov, P. Ya., Burlakova, E. B., Krasil’nikov, V. A., Sidorenko, L. I., and Todorov, I. N., 1978, Stimulation of the synthesis of components of the nuclear membrane of rat liver cells after inhibition of translation by cycloheximide, Biokhimiya 43: 1545–1550.

    Google Scholar 

  • Alonso, A., 1980, Nuclear ribonucleoproteins, Biochem. Soc. Trans 9: 30P.

    Google Scholar 

  • Alonso, A., Fischer, J., Konig, N., and Kinzel, V., 1981, Structural analysis of heterogeneous nuclear ribonucleoprotein particles approached by in vitrophosphorylation using exogenous protein kinase and gamma phosphorus-32 labeled ATP, Eur. J. Cell Biol 26: 208–211.

    PubMed  CAS  Google Scholar 

  • Arbuzov, V. A., 1977, Cycloheximide inhibition of nuclear-cytoplasmic transport of messenger RNA in rat liver cells, Dokl. Akad. Nauk SSSR 237: 721–724.

    PubMed  CAS  Google Scholar 

  • Arbuzov, V. A., and Krechetova, G. D., 1980, Nuclear cytoplasmic transport of messenger RNA in rat liver cells and hepatoma after inhibition of protein synthesis with cycloheximide, Vopr. Med. Khim 26: 354–361.

    PubMed  CAS  Google Scholar 

  • Arnold, E. A., Yawn, D. H., Brown, D. G., Wyllie, R. C., and Coffey, D. S., 1972, Structural alteration in isolated rat liver nuclei after removal of template restrictions by polyanions, J. Cell Biol 53: 737–757.

    Article  PubMed  CAS  Google Scholar 

  • Augenlicht, L. H., McCormick, M., and Lipkin, M., 1976, Digestion of RNA of chromatin and nuclear ribonucleoprotein by staphylococcal nuclease, Biochemistry 15: 3818–3823.

    Article  PubMed  CAS  Google Scholar 

  • Austin, G. E., Russo, R. J., and Moyer, G. H., 1978, Comparison of transcripts of unique DNA sequences in hepatomas induced by N-2-acetylaminofluorene and in rat liver, Fed. Proc. Fed. Am. Soc. Exp. Biol 37: N728.

    Google Scholar 

  • Aviv, H., Voloch, Z., Bastos, R., and Levy, S., 1976, Biosynthesis and stability of globin mRNA in cultured erythroleukaemic Friend cells, Cell 8: 495–503.

    Article  PubMed  CAS  Google Scholar 

  • Baer, B. W., and Kornberg, R. D., 1980, Repeating structure of cytoplasmic polyadenylated ribonucleoprotein, Proc. Natl. Acad. Sci. U.S.A 77: 1890–1892.

    Article  PubMed  CAS  Google Scholar 

  • Barrack, E. R., and Coffey, D. S., 1980, The specific binding of estrogens and androgens to the nuclear matrix of sex hormone responsive tissues, J. Biol. Chem 255: 7265–7275.

    PubMed  CAS  Google Scholar 

  • Barrieux, A., Ingraham, H. A., Nystul, S., and Rosenfeld, M., 1976, Characterization of the association of specific proteins with messenger ribonucleic acid, Biochemistry 15: 3523–3528.

    Article  PubMed  CAS  Google Scholar 

  • Bass, N. H., 1971, Influence of neonatal undernutrition on the development of rat cerebral cortex, in: Chemistry and Brain Development( R. Paoletti and A. N. Davidson, eds.), pp. 413–424, Plenum Press, New York.

    Google Scholar 

  • Bastian, C., 1978, Comparative studies on molecular hybridization of nuclear RNA synthesized by isolated rat liver: Effect of cytosol, Biochem. Biophys. Res. Commun 83: 893–900.

    Article  PubMed  CAS  Google Scholar 

  • Bastian, C., 1980, The effect of cytosol from regenerating rat liver on the in vitroRNA synthesis of isolated cell nuclei from a Morris hepatoma: Comparative studies on molecular hybridization of nuclear RNA, Biochem. Biophys. Res. Commun 92: 80–88.

    Article  PubMed  CAS  Google Scholar 

  • Bastos, R. N., and Aviv, H., 1977, Theoretical analysis of a model for globin messenger RNA accumulation during erythropoiesis, J. Mol. Biol 110: 191–203.

    Article  PubMed  CAS  Google Scholar 

  • Bayens, W., and Goutier, R., 1977, Modification in nucleocytoplasmic transport of RNA in vitroafter whole-body X-irradiation, Strahlentherapie 153: 769–773.

    Google Scholar 

  • Bayens, W., and Lemaire, M., 1978, Increased nucleocytoplasmic RNA transport in vitroinduced by hepatoma-D cytosol, Arch. Int. Physiol. Biochem 86: 903–905.

    Google Scholar 

  • Beltz, G. A., and Flint, S. J., 1979, Inhibition of HeLa cell protein synthesis during adenovirus infection: Restriction of cellular messenger RNA sequences to the nucleus, J. Mol. Biol 131: 353–373.

    Article  PubMed  CAS  Google Scholar 

  • Berezney, R., 1979, Dynamics of the nuclear protein matrix, in: The Cell Nucleus, Vol. 7 ( H. Busch, ed.), pp. 413–455, Academic Press, New York.

    Google Scholar 

  • Berezney, R., 1980, Fractionation of the nuclear matrix. I. Partial separation into matrix protein fibrils and a residual ribonucleoprotein fraction, J. Cell Biol 85: 641–650.

    Article  PubMed  CAS  Google Scholar 

  • Berezney, R., and Buckholtz, L. A., 1978, Nuclear matrices isolated with protease inhibitors: Evidence for an increased association of newly-replicated DNA, J. Cell Biol 79: 130a.

    Google Scholar 

  • Berezney, R., and Coffey, D. S., 1974a, Identification of a nuclear protein matrix, Biochem. Biophys. Res. Commun 60:1410–1417.

    Article  CAS  Google Scholar 

  • Berezney, R., and Coffey, D. S. 1974b, Identification of a nuclear structural network in rat liver nuclei, Fed. Proc. Fed. Am. Soc. Exp. Biol 33: 1395.

    Google Scholar 

  • Berezney, R., and Coffey, D. S. 1976, The nuclear protein matrix: Isolation, structure and functions, Adv. Enzyme Regul 14: 63–100.

    Article  PubMed  CAS  Google Scholar 

  • Beyer, A. L., Christiensen, M. E., Walker, B. W., and Le Stourgeon, W. M., 1977, Identification and characterization of the packaging proteins of core 40S HnRNP Particles, Cell 11:127–138.

    Article  PubMed  CAS  Google Scholar 

  • Bier, K., 1965, Uber den Transport zelleigener Makromoleküle durch die Kernmembran. I. RNS-Synthese und Transport unter Sauerstoffmangel und bei herabgesetzter Temperatur, Chromosoma 16: 58–69.

    Article  PubMed  CAS  Google Scholar 

  • Birnie, G. D., MacPhail, E., Young, B. D., Getz, M. J., and Paul, J., 1974, The diversity of the messenger RNA population in growing Friend cells, Cell Differ 3: 221–232.

    Article  PubMed  CAS  Google Scholar 

  • Birnstiel, M., 1981, Histones and their regulation, Biochem. Soc. Trans 9: 87P.

    Google Scholar 

  • Bishop, J. O., Morton, J. G., Rosbach, M., and Richardson, M., 1974, Three abundance classes in HeLa cell messenger RNA, Nature (London) 250: 199–204.

    Article  CAS  Google Scholar 

  • Biswas, D. K., 1978, RNA protein interactions in a cell-free system with isolated nuclei from GH-3 cells, Biochemistry 17: 1131–1136.

    Article  PubMed  CAS  Google Scholar 

  • Blanchard, J. M., Brissac, C., and Jeanteur, P., 1974, Protein species isolated from HeLa cell cytoplasm: Characterization by affinity chromatography on polyadenylate-Sepharose, Proc. Natl. Acad. Sci. U.S.A 71: 1882–1886.

    Article  PubMed  CAS  Google Scholar 

  • Blanchard, J. M., Ducamp, C., and Jeanteur, P., 1975, Endogenous protein kinase activity in nuclear RNP particles from HeLa cells, Nature (London) 253: 467–468.

    Article  CAS  Google Scholar 

  • Blanchard, J. M., Brunel, C., and Jeanteur, P., 1977, Characterization of an endogenous protein kinase activity in ribonucleoprotein structures containing HnRNA from HeLa cell nuclei, Eur. J. Biochem 79: 117–131.

    Article  PubMed  CAS  Google Scholar 

  • Blanchard, J. M., Brunel, C., and Jeanteur, P., 1978, Phosphorylation in vivoof proteins associated with heterogeneous nuclear RNA in HeLa cell nuclei, Eur. J. Biochem 86: 301–310.

    Article  PubMed  CAS  Google Scholar 

  • Blobel, G., 1973, A protein of molecular weight 78,000 bound to the polyadenylate region of eukaryotic messenger RNA’s, Proc. Natl. Acad. Sci. U.S.A 70: 924–928.

    Article  PubMed  CAS  Google Scholar 

  • Blumberg, D. D., and Lodish, H. F., 1981, Changes in the complexity of nuclear RNA during development of Dictyostelium discoideum, Dev. Biol 81: 74–80.

    Article  PubMed  CAS  Google Scholar 

  • Bolund, L. Ringertz, N. R., and Harris, H., 1969, Changes in the cytochemical properties of erythrocyte nuclei reactivated by cell fusion, J. Cell Sci 4: 71–87.

    PubMed  CAS  Google Scholar 

  • Bornens, M., 1973, Action of heparin on nuclei: Solubilization of chromatin enabling the isolation of the nuclear membranes, Nature (London) 244: 28–30.

    Article  CAS  Google Scholar 

  • Braude, P., Pelham, H., Flach, G., and Lobatto, R., 1979, Post-transcriptional control in the early mouse embryo, Nature (London) 282: 102–104.

    Article  CAS  Google Scholar 

  • Britten, R. J., and Davidson, E. H., 1969, Gene regulation for higher cells: A theory, Science 165: 349–357.

    Article  PubMed  CAS  Google Scholar 

  • Brown, D. G., and Coffey, D. S., 1971, Release of nuclear template restrictions by specific polyribonucleotides, Science 171: 176–178.

    Article  PubMed  CAS  Google Scholar 

  • Brown, D. G., and Coffey, D. S., 1972, Effects of polyinosinic acid on the deoxyribonucleic acid template activity of isolated nuclei and soluble chromatin from rat liver, J. Biol. Chem 247: 7674–7683.

    PubMed  CAS  Google Scholar 

  • Brunner, M., and Raskas, H. J., 1972, Processing of adenovirus RNA before release from isolated nuclei, Proc. Natl. Acad. Sci. U.S.A 69: 3101–3104.

    Article  PubMed  CAS  Google Scholar 

  • Buldiaeva, T. V., Kuzmina, S. N., and Zbarsky, I. B., 1979, Protein composition of matrix and residual proteins of rat liver and hepatoma-27 nuclei, Dokl. Acad. Nauk. SSSR 241: 1161–1164.

    Google Scholar 

  • Cannon, M., Carter, C. J., Davies, J., and Littlewood, M., 1979, A mutant of Saccharomyces cerevisiaethat possesses unusual ribosomes, Biochem. Soc. Trans 7: 668–670.

    PubMed  CAS  Google Scholar 

  • Carter, C. J., Cannon, M., and Jiménez, A., 1980, A trichodermin-resistant mutant of Saccharomyces cerevisiaewith an abnormal distribution of native ribosomal subunits, Eur. J. Biochem 107: 173–183.

    Article  PubMed  CAS  Google Scholar 

  • Chap, L. N. L., 1976, Transport of globin mRNA from nucleus into cytoplasm in differentiating embryonic red blood cells, Nature (London) 261: 157–159.

    Article  CAS  Google Scholar 

  • Chardonnet, Y., and Dales, S., 1973, Early events in the interaction of adenoviruses and HeLa cells. III. Relationship between an ATPase activity in nuclear envelopes and transfer of core material—a hypothesis, Virology 48: 342–359.

    Article  Google Scholar 

  • Chatterjee, N. K., and Weissbach, H., 1973, Release of RNA from HeLa cell nuclei, Arch. Biochem. Biophys 157: 160–166.

    Article  PubMed  CAS  Google Scholar 

  • Chisick, M. C., Brennessel, B. A., and Biswas, D. K., 1979, Poly(A)-protein interactions and transport of mRNA in isolated nuclei, Biochem. Biophys. Res. Commun 91: 1109–1116.

    Article  PubMed  CAS  Google Scholar 

  • Church, R. B., and McCarthy, B. J., 1967, Changes in nuclear and cytoplasmic RNA in regenerating mouse liver, Proc. Natl. Acad. Sci. U.S.A 58: 1548–1553.

    Article  PubMed  CAS  Google Scholar 

  • Church, R. B., and McCarthy, B. J., 1970, Unstable nuclear RNA synthesis following estrogen stimulation, Biochim. Biophys. Acta 199: 103–114.

    PubMed  CAS  Google Scholar 

  • Church, R., Luther, S. W., and McCarthy, B. J., 1969, RNA synthesis in Taper hepatoma and mouse liver cells, Biochim. Biophys. Acta 190: 30–37.

    PubMed  CAS  Google Scholar 

  • Clawson, G. A., and Smuckler, E. A., 1978, Activation energy for RNA transport from isolated rat liver nuclei, Proc. Natl. Acad. Sci. U.S.A 75: 5400–5404.

    Article  PubMed  CAS  Google Scholar 

  • Clawson, G. A., and Smuckler, E. A., 1979, Reciprocity between nuclear envelope nucleoside triphosphatase and RNA transport, J. Cell Biol 83: 146a.

    Google Scholar 

  • Clawson, G. A., and Smuckler, E. A., 1980, Altered restriction of nuclear RNA during incubation in vivo, Biochem. Biophys. Res. Commun 95: 696–700.

    Article  PubMed  CAS  Google Scholar 

  • Clawson, G. A., Koplitz, M., Castler-Schechter, B., and Smuckler, E. A., 1978, Energy utilization and RNA transport: Their interdependence, Biochemistry 17: 3747–3752.

    Article  PubMed  CAS  Google Scholar 

  • Clawson, G. A., James, J., Woo, C. H., Friend, D. S., Moody, D., and Smuckler, E. A., 1980a, Pertinence of nuclear envelope nucleoside triphosphatase activity. to ribonucleic acid transport, Biochemistry 19: 2756–2762.

    Article  Google Scholar 

  • Clawson, G. A., Koplitz, M., Moody, D. E., and Smuckler, E. A., 1980b, Effects of thioacetamide treatment on nuclear envelope nucleoside triphosphatase activity and transport of RNA from rat liver nuclei, Cancer Res 40: 75–79.

    CAS  Google Scholar 

  • Clawson, G. A., Woo, C. H., and Smuckler, E. A., 1980c, Independent responses of nucleoside triphosphatase and protein kinase activities in nuclear envelope following thioacetamide treatment, Biochem. Biophys. Res. Commun 95: 1200–1204.

    Article  CAS  Google Scholar 

  • Coffey, D. S., Barrack, E. R., and Heston, W. D. W., 1974, The regulation of nuclear DNA template restrictions by acidic polymers, Adv. Enzyme Regul 12: 229–289.

    Article  Google Scholar 

  • Cooper, H. L., 1969, Ribosomal ribonucleic acid production and growth regulation in human lymphocytes, J. Biol. Chem 244: 1946–1952.

    PubMed  CAS  Google Scholar 

  • Cooper, H. L., and Gibson, E. M., 1971, Control of synthesis and wastage of ribosomal RNA in lymphocytes. II. The role of protein synthesis, J. Biol. Chem 246: 5059–5066.

    PubMed  CAS  Google Scholar 

  • Cordone, A., Fugassa, E., Gallo, G., and Voci, A., 1980, Labeling pattern of RNA in isolated perfused rat liver, Boll. Soc. Ital. Biol. Sper 56: 295–301.

    PubMed  CAS  Google Scholar 

  • Cumming, R., Koide, Y., Krigman, M. R., Beavo, J. A., and Steiner, A. L., 1981, Immunofluorescent localization of regulatory and catalytic subunits of cyclic AMP dependent protein kinase in neuronal and glial cell types of the central nervous system, Neuroscience 6: 953–962.

    Article  PubMed  CAS  Google Scholar 

  • Darnell, J. E., Philipson, L., Wall, R., and Adesnik, M., 1971, Polyadenylic acid sequences: Role in conversion of nuclear RNA into messenger RNA, Science 174:507–510.

    Article  PubMed  CAS  Google Scholar 

  • Darnell, J. E., Jelink, W. R., and Molloy, G. R., 1973, Biogenesis of mRNA: Genetic regulation in mammalian cells, Science 181: 1215–1221.

    Article  PubMed  CAS  Google Scholar 

  • Davidson, E. H., and Britten, R. J., 1979, Regulation of gene expression: Possible role of repetitive sequences, Science 204: 1052–1059.

    Article  PubMed  CAS  Google Scholar 

  • Doshchanov, Kh. I., Poushchariov, V. M., Polimdetova, N. S., and Ajtkhozhin, M. A., 1981, The release of the informosomes from isolated nuclei of wheat embryos in an in vitrosystem, Mol. Biol. (Kiev) 15: 72–78.

    CAS  Google Scholar 

  • Drews, J., Brawerman, G., and Morris, H. P., 1968, Nucleotide sequence homologies in nuclear and cytoplasmic ribonucleic acid from rat liver and hepatomas, Eur. J. Biochem 3: 284–292.

    Article  PubMed  CAS  Google Scholar 

  • Duvilanski, B. H., Ramirez de Guglielmone, A. B., and Gómez, C. J., 1980, Nucleocytoplasmic transport of RNA and protein synthesis in developing brain from normal and undernourished rats, J. Neurochem 34: 226–230.

    Article  PubMed  CAS  Google Scholar 

  • Dwyer, N., and Blobel, G., 1976, A modified procedure for the isolation of a pore-complexlamina fraction from rat liver nuclei, J. Cell Biol 70: 581–591.

    Article  PubMed  CAS  Google Scholar 

  • Egyhazi, E., 1974, Actinomycin D and RNA transport, Nature (London) 250: 221–222.

    Article  CAS  Google Scholar 

  • Ephrussi, B., 1972, Hybridization of Somatic Cells, Oxford University Press, London.

    Google Scholar 

  • Fabergé, A. C., 1974, The nuclear pore complex: Its free existence and an hypothesis as to its origin, Cell Tissue Res 151: 403–415.

    Article  PubMed  Google Scholar 

  • Faiferman, I., and Pogo, A. O., 1975, Isolation of a nuclear ribonucleoprotein network that contains heterogeneous RNA and is bound to the nuclear envelope, Biochemistry 14: 3808–3816.

    Article  PubMed  CAS  Google Scholar 

  • Feldherr, C. M., 1973, The effect of temperature on nuclear permeability, Experientia 29: 546–547.

    Article  PubMed  CAS  Google Scholar 

  • Feldherr, C. M., 1980, Ribosomal RNA synthesis and transport following disruption of the nuclear envelope, Cell Tissue Res 205: 157–162.

    Article  PubMed  CAS  Google Scholar 

  • Feldherr, C. M., and Pomerantz, J., 1978, Mechanism for the selection of nuclear polypeptides in Xenopus oocytes, J. Cell Biol 78: 168–175.

    Article  PubMed  CAS  Google Scholar 

  • Firtel, R. A., 1981, Regulation of gene activity during cell differentiation in Dictyostelium, Biochem. Soc. Trans 9: 88P.

    Google Scholar 

  • Flickinger, C. J., 1970, The fine structure of the nuclear envelope in amoebae: Alterations following nuclear transplantation, Exp. Cell Res 60: 225–236.

    Article  PubMed  CAS  Google Scholar 

  • Flickinger, R. A., and Roche, F. M., 1972, Effect of triiodothyronine on the transcription of deoxyribonucleic acids of different degrees of redundancy in frog larvae, Biochem. J 130: 319–320.

    PubMed  CAS  Google Scholar 

  • Franke, W. W., 1974, Structure, biochemistry and functions of the nuclear envelope, Int. Rev. Cytol. Suppl 4: 72–236.

    Google Scholar 

  • Franke, W. W., and Scheer, U., 1974, Structure and functions of the nuclear envelope, in: The Cell Nucleus, Vol. 1 ( H. Busch, ed.), pp. 279–347, Academic Press, New York.

    Google Scholar 

  • Fry, D. J., 1976, The isolation of nuclear envelopes, in: Subcellular Components( G. D. Birnie, ed.), pp. 59–105, Butterworths, London.

    Google Scholar 

  • Fuller, B. B., and Hadley, M. E., 1979, Transcription and translation requirements for MSH stimulation of tyrosinase in melanoma cells, Pigment Cell 4: 97–104.

    Google Scholar 

  • Gajdardjieva, K. C., Dabeva, M. D., and Hadjiolov, A. A., 1980, Maturation and nucleocytoplasmic transport of rat liver ribosomal RNA upon D-galactosamine inhibition of transcription, Eur. J. Biochem 104: 451–458.

    Article  PubMed  CAS  Google Scholar 

  • Garret, C. T., Katz, C., Moore, R. E., and Pitot, H. C., 1973a, Competitive DNA-RNA hybridization of microsomal and nuclear RNA in normal tissues of the rat, Cancer Res 33: 1662–1669.

    Google Scholar 

  • Garret, C. T., Moore, R. E., Katz, C., and Pitot, H. C., 1973b, Competitive DNA-RNA hybridization of nuclear and microsomal RNA in normal, neoplastic and neonatal liver tissues, Cancer Res 33: 2464–2468.

    Google Scholar 

  • Gerace, L., and Blobel, G., 1980, The nuclear envelope lamina is reversibly depolymerized during mitosis, Cell 19: 277–288.

    Article  PubMed  CAS  Google Scholar 

  • Gerace, L., Blum, A., and Blobel, G., 1978, Immunochernical localization of the major polypeptides of the nuclear pore-lamina fraction: Interphase and mitotic distribution, J. Cell Biol 79: 546–566.

    Article  PubMed  CAS  Google Scholar 

  • Ghittoni, N. E., and Faryna de Raveglia, I., 1972, Influence of neonatal undernutrition on the lipid composition of cerebral cortex and cerebellum of the rat, Neurobiology 2: 41–48.

    PubMed  CAS  Google Scholar 

  • Ghosh, S., Pawletz, N., and Ghosh, I., 1978, Cytological identification and characterisation of the nuclear matrix, Exp. Cell Res 111: 363–371.

    Article  PubMed  CAS  Google Scholar 

  • Giese, G., Fromme, I., and Wunderlich, F., 1979, Suppression of thermotropic lipid clustering in Tetrahymenanuclear membranes upon Ca2+/Mg2+-induced membrane contraction, Eur. J. Biochem 95: 275–285.

    Article  PubMed  CAS  Google Scholar 

  • Giodl, J. A., Canaani, D., Boublik, M., Weissbach, H., and Deckermann, H., 1975, Polyanioninduced release of polyribosomes from HeLa cell nuclei, J. Biol. Chem 250: 9198–9205.

    Google Scholar 

  • Goldfine, I. D., Vigneri, R., Cohen, D., Pliam, N. B., and Kahn, C. R., 1977, Intracellular binding sites for insulin are immunologically distinct from those on the plasma membrane, Nature (London) 269: 698–700.

    Article  CAS  Google Scholar 

  • Goldstein, J., 1966, Resistance of RNA to thermal denaturation in the presence of polyamines, Biochim. Biophys. Acta 123: 620–623.

    PubMed  CAS  Google Scholar 

  • Goldstein, L., and Trescott, O. H., 1970, Characterisation of RNAs that do and do not migrate between cytoplasm and nucleus, Proc. Natl. Acad. Sci. U.S.A 67:1367–1374.

    Article  PubMed  CAS  Google Scholar 

  • Greene, R. F., and Fausto, N., 1974, Studies on poly(A) sequences associated with regenerating liver RNA, Biochim. Biophys. Acta 366: 23–34.

    PubMed  CAS  Google Scholar 

  • Gurdon, J. B., and Woodland, H. R., 1968, The cytoplasmic control of nuclear activity in animal development, Biol. Rev 43: 233–267.

    Article  PubMed  CAS  Google Scholar 

  • Hall, C., and Lim, L., 1978, The metabolism of high molecular weight RNA in hypothalamic and cortical regions of the developing female rat brain, Biochem. J 176: 511–522.

    PubMed  CAS  Google Scholar 

  • Harris, H., 1967, The reactivation of the red cell nucleus, J. Cell Sci 2: 23–32.

    PubMed  CAS  Google Scholar 

  • Harris, J. R., 1978, The biochemistry and ultrastructure of the nuclear envelope, Biochim. Biophys. Acta 515: 55–104.

    PubMed  CAS  Google Scholar 

  • Harris, J. R., and Agutter, P. S., 1976, The isolation and characterisation of the nuclear envelope, in: Biochemical Analysis of Membranes( A. H. Madly, ed.), pp. 132–173, Chapman and Hall, London.

    Google Scholar 

  • Harris, J. R., and Milne, J. F., 1974, A rapid procedure for the isolation and purification of rat liver nuclear envelope, Biochem. Soc. Trans 2: 1251–1253.

    CAS  Google Scholar 

  • Hazan, N., and McCauley, R., 1976, Effect of phenolbarbitone on the nucleocytoplasmic transport of ribonucleic acid in vitro, Biochem. J 156: 665–670.

    PubMed  CAS  Google Scholar 

  • Heilmann, W., and Hardeland, R., 1977, Nucleocytoplasmic transport of messenger RNA, Naturwissenschaften 64: 644–645.

    Article  PubMed  CAS  Google Scholar 

  • Heinrich, R. C., Gross, V., Northeman, W., and Scheurlen, M., 1978, Structure and function of nuclear ribonucleoprotein complexes, Rev. Physiol. Biochem. Pharmacol 81: 102–134.

    Google Scholar 

  • Herlan, G., Quevedo, R., and Wunderlich, F., 1978, Structural transformations of nuclear matrix in situ, Exp. Cell Res 115: 103–110.

    Article  PubMed  CAS  Google Scholar 

  • Herlan, G., Eckert, W. A., Kaffenberger, W., and Wunderlich, F., 1979a, Isolation and characterization of an RNA-containing nuclear matrix from Tetrahymenamacronuclei, Biochemistry 18: 1782–1787.

    Article  CAS  Google Scholar 

  • Herlan, G., Giese, G., and Wunderlich, F., 1979b, Influence of nuclear membrane lipid fluidity on nuclear RNA release, Exp. Cell Res 118: 305–310.

    Article  CAS  Google Scholar 

  • Herman, R. C., Williams, J. G., and Penman, S., 1976, Messenger and non-messenger sequences adjacent to poly(A) in steady-state heterogeneous nuclear RNA in HeLa cells, Cell 7: 429–437.

    Article  PubMed  CAS  Google Scholar 

  • Herman, R., Weymouth, L., and Penman, S., 1978, Heterogeneous nuclear RNA-protein fibers in chromatin-depleted nuclei, J. Cell Biol 78: 663–674.

    Article  PubMed  CAS  Google Scholar 

  • Hillman, N., and Tasca, R. J., 1969, Ultra-structural and autoradiographic studies of mouse cleavage states, Am. J. Anat 126: 151–174.

    Article  PubMed  CAS  Google Scholar 

  • Holtzer, H., Weintraub, H., and Mayne, R., 1972, The cell cycle, cell lineages and cell differentiation, Curr. Top. Dev. Biol 7: 229–256.

    Article  PubMed  CAS  Google Scholar 

  • Horisberger, M., and Amos, H., 1970a, Ribonucleic acid synthesis and transport in animal cells at 27°C, Biochem. J 117: 347–353.

    CAS  Google Scholar 

  • Horisberger, M., and Amos, H., 1970b, Nuclear-cytoplasmic exchange of RNA and protein: Effect of temperature and serum, Exp. Cell Res 62: 467–470.

    Article  CAS  Google Scholar 

  • Horowitz, S. B., and Paine, P. L., 1976, Cytoplasmic exclusion as a basis for asymmetric nucleocytoplasmic solute distributions, Nature (London) 260: 151–153.

    Article  CAS  Google Scholar 

  • Horowitz, S. B., and Paine, P. L., 1979, Reference phase analysis of free and bound intracellular solutes. II. Isothermal and isotopic studies of cytoplasmic sodium, potassium and water, Biophys. J 25: 45–62.

    Article  PubMed  CAS  Google Scholar 

  • Horowitz, S. B., Paine, P. L., Tluczek, L. J. M., and Reynhout, J. K., 1979, Reference phase analysis of free and bound intracellular solutes. I. Sodium and potassium in amphibian oocytes, Biophys. J 25: 33–44.

    Article  PubMed  CAS  Google Scholar 

  • Ikemura, T., 1969, The relation between the strong binding of spermine to polynucleotides and the conformation of polynucleotides, Biochim. Biophys. Acta 195: 389–395.

    PubMed  CAS  Google Scholar 

  • Ishikawa, K., Kuroda, C., and Ogata, K., 1969, Release of ribonucleoprotein particles containing rapidly-labeled ribonucleic acid from rat liver nuclei: Effect of adenosine 5’-triphosphate and some properties of the particles, Biochim. Biophys. Acta 179: 316–331.

    PubMed  CAS  Google Scholar 

  • Ishikawa, K., Kuroda, C., Ueki, M., and Ogata, K., 1970a, Messenger ribonucleoprotein complexes released from rat liver nuclei by ATP. I. Characterization of the RNA moiety of messenger ribonucleoprotein complexes, Biochim. Biophys. Acta 213: 495–504.

    CAS  Google Scholar 

  • Ishikawa, K., Kuroda, C., Ueki, M., and Ogata, K., 1970b, Messenger ribonucleoprotein complexes released from rat liver nuclei by ATP. II. Chemical and metabolic properties of the mRNP complexes, Biochim. Biophys. Acta 213: 505–512.

    CAS  Google Scholar 

  • Ishiwaka, K., Ueki, M., Nakai, K., and Ogata, K., 1970c, Incorporation of nuclear rapidly-labeled RNA into polysomes in the reconstructed system of rat liver, Biochim. Biophys. Acta 213: 542–544.

    Google Scholar 

  • Ishikawa, K., Ueki, M., Nakai, K., and Ogata, K., 1972, Transportation of messenger RNA from nuclei to polysomes in rat liver cells, Biochim. Biophys. Acta 259: 138–154.

    PubMed  CAS  Google Scholar 

  • Ishikawa, K., Sato, T., Sato, S., and Ogata, K., 1974, Ribonucleoprotein complexes containing nascent DNA-like RNA in the crude chromatin fraction of rat liver, Biochim. Biophys. Acta 353: 420–437.

    PubMed  CAS  Google Scholar 

  • Ishikawa, K., Sato-Odani, S., and Ogata, K., 1978, The role of ATP in the transport of rapidly-labeled RNA from isolated nuclei of rat liver in vitro, Biochim. Biophys. Acta 521: 650–661.

    PubMed  CAS  Google Scholar 

  • Jacquet, M., Affara, N. A., Robert, B., Jacob, H., Jacob, F., and Gros, F., 1978, Complexity of nuclear and polysomal polyadenylated RNA in a pluripotent embryonal carcinoma cell line, Biochemistry 17: 69–79.

    Article  PubMed  CAS  Google Scholar 

  • Jefferson, L. S., Boyd, T. A., Flaim, K. E., and Peavy, D. E., 1980, Regulation of protein synthesis in perfused preparations of rat heart, skeletal muscle and liver, Biochem. Soc. Trans 8: 282–283.

    PubMed  CAS  Google Scholar 

  • Kashnig, D. M., and Kasper, C. B., 1969, Isolation, morphology and composition of the nuclear membrane from rat liver, J. Biol. Chem 244:3786–3792.

    PubMed  CAS  Google Scholar 

  • Kasper, C. B., and Lam, K. S., 1980, Molecular orientation and phosphorylation of major nuclear envelope polypeptides, Eur. J. Cell Biol 22: 122.

    Google Scholar 

  • Kaufmann, S. H., Coffey, D. S., and Shaper, J. H., 1981, Considerations in the isolation of rat liver nuclear matrix, nuclear envelope and pore complex lamina, Exp. Cell Res 132: 105–123.

    Article  PubMed  CAS  Google Scholar 

  • Kawashima, K., Izawa, M., and Sato, S., 1971, Studies on the origin of proteins in the nucleoli of mouse ascites tumour cells: A test for protein transfer to nucleoli, Biochim. Biophys. Acta 232: 192–206.

    PubMed  CAS  Google Scholar 

  • Kay, R. R., Fraser, D., and Johnston, I. R. 1972, A method for the rapid isolation of nuclear membranes from rat liver, Eur. J. Biochem. 30: 145–154.

    Article  PubMed  CAS  Google Scholar 

  • Klenow, H., 1963, Formation of the mono-, di- and triphosphate of cordycepin in Ehrlich ascites tumor cells in vitro, Biochim. Biophys. Acta 76: 347–353.

    Article  PubMed  CAS  Google Scholar 

  • Kletzein, R. F., 1975, Transport of RNA from isolated nuclei—the role of ATP, J. Cell Biol 67: 217a.

    Google Scholar 

  • Kletzein, R. F., 1980, Nucleocytoplasmic transport of RNA: Effect of 3’ deoxy ATP on RNA release from isolated nuclei, Biochem. J 192: 753–760.

    Google Scholar 

  • Kletzein, R. F., 1981, Nuclear membrane associated protein kinase and substrates: The effects of growth state on activity and specificity, Biochem. J 196: 853–860.

    Google Scholar 

  • Knowland, J., and Graham, C., 1972, RNA synthesis at the two-cell stage of mouse development, J. Embryol. Exp. Morphol 27: 167–176.

    PubMed  CAS  Google Scholar 

  • Koen, Y. M., and Zbarsky, I. B., 1978, RNA transport from liver cell nuclei: In vitrorelease of rapidly-labelled RNA from isolated nuclei in a cell-free system in the presence of RNAase effectors, Biokhimiya 43: 2115–2123.

    CAS  Google Scholar 

  • Koen, Y. M., Peskin, A. V., Baru, V. A., Fedorchenko, V. V., Zbarsky, I. B., and Konstantinov, A. A., 1978, RNA transport from liver cell nuclei in vitro: Effect of superoxide dismutase on the release of rapidly labelled RNA, Biokhimiya 43: 1673–1678.

    Google Scholar 

  • Köhler, K., and Arends, S., 1968, Particles of nuclear origin containing rapidly labelled RNA, Eur. J. Biochem 5: 500–506.

    Article  PubMed  Google Scholar 

  • Kostomarova, A. A., 1977, RNA transport in embryo cells, Ontogenesis 8: 630–648.

    CAS  Google Scholar 

  • Kozinets, G. I., Bykova, I. A., and Zubarenko, A. V., 1980, Nuclear cytoplasmic RNA transport in hemopoietic cells under normal conditions and in leukemia, Probl. Gematol. Percliv. Krovi 25: 11–14.

    CAS  Google Scholar 

  • Kraemer, R. J., and Coffey, D. S., 1970, The interaction of natural and synthetic polyanions with mammalian nuclei. II. Nuclear swelling, Biochim. Biophys. Acta 224: 568–578.

    PubMed  CAS  Google Scholar 

  • Kumar, A., Satyanarayana Rao, M. R., and Padmanaban, G., 1980, A comparative study of the early effects of Phenobarbital and 3-methylcholanthrene on the synthesis and transport of ribonucleic acid in rat, liver, Biochem. J 186: 81–87.

    PubMed  CAS  Google Scholar 

  • Kuz’mina, S. N., Troitskaya, L. P., Mirkhamidova, P. A., Bul’dyaeva, T. V., Zbarsky, I. B., and Grigoriov, V. B., 1979, Nuclear pore density in rat liver cells during regeneration and total body X-irradiation, Tsitologiya 21: 875–881.

    Google Scholar 

  • Laemmli, U. K., Lewis, C. D., and Lebkowski, J. S., 1981, Chromosome structural studies, Biochem. Soc. Trans 9: 6P.

    Google Scholar 

  • Lam, K. S., and Kasper, C. B., 1979, Selective phosphorylation of a nuclear envelope polypeptide by an endogenous protein kinase, Biochemistry 18: 307–311.

    Article  PubMed  CAS  Google Scholar 

  • Lasky, L., Nozick, N. D., and Tobin, A. J., 1978, Few transcribed RNAs are translated in avian erythroid cells, Dev. Biol 67: 23–39.

    Article  PubMed  CAS  Google Scholar 

  • Lau, A. S., Baliga, B. S., Roy, R. K., Sarkar, S., and Munro, H. N., 1980, Synthesis and processing of RNA by isolated human placental nuclei, Placenta 1: 169–182.

    Article  PubMed  CAS  Google Scholar 

  • Lazarus, H. M., and Hopfenbeck, A., 1981, Effects of organ preservation on the transport of RNA from the nucleus, Proc. Soc. Exp. Biol. Med 166: 221–227.

    PubMed  CAS  Google Scholar 

  • Leake, R. E., Trench, M. E., and Barry, J. M., 1972, Effect of cations on the condensation of hen erythrocyte nuclei and its relation to gene activation, Exp. Cell Res 71: 17–26.

    Article  PubMed  CAS  Google Scholar 

  • Lemaire, M., and Bayens, W., 1979, Modified nucleocytoplasmic RNA transport in vitroinduced by cytosols derived from hepatoma-D at different stages of development, Arch. Int. Physiol. Biochem 87: 821–822.

    CAS  Google Scholar 

  • Lemaire, M., Bayens, W., and Baugnet-Mahieu, L., 1981, On the altered nucleocytoplasmic transport in vitroof rapidly-labelled RNA, in the presence of cytosol or serum from tumourbearing rats, Biomedicine 34: 47–53.

    PubMed  CAS  Google Scholar 

  • Lenk, R., Herman, R., and Penman, S., 1978, Messenger RNA abundance and lifetime: A correlation in Drosophila cells but not in HeLa, Nucleic Acids Res 5: 3057–3070.

    Article  PubMed  CAS  Google Scholar 

  • Levitsky, D. A., and Barnes, R. H., 1972, Nutritional and environmental interactions in the behavioural development of the rat: Long-term effects, Science 176: 68–71.

    Article  PubMed  CAS  Google Scholar 

  • Levy, W. B., and McCarthy, B. J., 1975, Messenger RNA complexity in Drosophila melanogaster, Biochemistry 14: 2440–2446.

    Article  Google Scholar 

  • Lichtenstein, A. V., and Shapot, V. S., 1976, A model for cytoplasm-governed gene regulation, Biochem. J 159: 783–794.

    PubMed  CAS  Google Scholar 

  • Lichtenstein, A. V., Alechina, R. P., and Shapot, V. S., 1978, Studies on informational RNAs and ribonucleoproteins of normal rat liver, Zajdela hepatoma and liver of hepatoma-bearing rats, Eur. J. Cancer 14: 939–947.

    PubMed  CAS  Google Scholar 

  • Lichtenstein, A. V., Zaboykin, M. M., Mojseev, V. L., and Shapot, V. S., 1981, Nucleus and cytoplasm: Supply and demand. What underlies the flow of genetic information?, in: Subcellular Biochemistry, Vol. 8 ( D. B. Roodyn, ed.), pp. 185–250, Plenum Press, New York.

    Google Scholar 

  • Long, B. H., Huang, C.-Y., and Pogo, A. O., 1979, Isolation and characterization of the nuclear matrix in Friend erythroleukaernia cells: Chromatin and heterogeneous RNA interactions with the nuclear matrix, Cell 18: 1079–1090.

    Article  PubMed  CAS  Google Scholar 

  • Luetzeler, J., Verney, E., and Sidransky, H., 1979, Nucleolar-cytoplasmic transport of RNA in livers of rats fed on a deficient diet, Exp. Mot. Pathol 31: 261–268.

    Article  CAS  Google Scholar 

  • Lund-Larsen, T., and Berg, T., 1973, Effect of heavy-metal ions and dexamethasone on the release of messenger RNA from liver nuclei of normal and adrenalectomized cortisol treated rats, Hoppe-Seyler’s Z. Physiol. Chem 354: 1334–1338.

    Article  PubMed  CAS  Google Scholar 

  • Maale, G., Stein, G., and Mans, R., 1975, Effects of cordycepin and cordycepin triphosphate on polyadenylic and ribonucleic acid-synthesising enzymes from eukaryotes, Nature (London) 255: 80–82.

    Article  CAS  Google Scholar 

  • Månsson, P. E., and Harris, S. E., 1979, Complexity of poly(A)-containing heterogeneous nuclear ribonucleic acid from mouse embryoid bodies (OTT 6050), Biochemistry 18: 2073–2078.

    Article  PubMed  Google Scholar 

  • Mariman, E. C. M., van Eekelen, C. A. G., Reinders, R. J., Berns, A. J. M., and van Venrooij, W. J., 1982, Adenoviral heterogeneous nuclear RNA is associated with the host nuclear matrix during splicing, J. Mol. Biol 154: 103–120.

    Article  PubMed  CAS  Google Scholar 

  • Marshall, P., and Harris, J. R., 1979, Isolation of nuclear pore complexes from Triton X-100 extracted rat liver nuclear envelope, Biochem. Soc. Trans 7: 928–929.

    PubMed  CAS  Google Scholar 

  • Maul, G. G., 1977, The nuclear and the cytoplasmic pore complex: Structure, dynamics, distribution and evolution, Int. Rev. Cytol. Suppl 6: 75–186.

    PubMed  CAS  Google Scholar 

  • Maul, G. G., 1980, Determination of newly synthesized and phosphorylated nuclear proteins in mass-isolated germinal vesicle of Spisula solidissima, Exp. Cell Res 129: 431–438.

    Article  PubMed  CAS  Google Scholar 

  • Maul, G. G. (ed.), 1982, The Nuclear Envelope and the Nuclear Matrix, Wistar Symposium Series, Vol. 2, Alan R. Liss, New York.

    Google Scholar 

  • Maul, G. G., and Avdalovic, N., 1980, Nuclear envelope proteins from Spisula solidissimagerminal vesicles, Exp. Cell Res 130: 229–240.

    Article  PubMed  CAS  Google Scholar 

  • Maul, G. G., and Wiebel, J., 1983, Production of microcytospheres, J. Histochem. Cytochem (in press).

    Google Scholar 

  • Maul, G. G., Deaven, L. L., Freed, J. J., Campbell, G. Le M., and Beçak, W., 1980, Investigation of the determinants of nuclear pore number, Cytogenet. Cell Genet 26: 175–190.

    Article  PubMed  CAS  Google Scholar 

  • Mauron, A., and Spohr, G., 1978, Frequency distribution of mRNA and pre-mRNA in growing and differentiated Friend cells, Nucleic Acids Res 5:3013–3032.

    Article  PubMed  CAS  Google Scholar 

  • McDonald, J. R., and Agutter, P. S., 1980, The relationship between polyribonucleotide binding and the phosphorylation and dephosphorylation of nuclear envelope protein, FEBS Lett 116: 145–148.

    Article  PubMed  CAS  Google Scholar 

  • McNamara, D. J., Racevskis, J., Schumm, D. E., and Webb, T. E., 1975, Ribonucleic acid synthesis in isolated rat liver nuclei under conditions of ribonucleic acid processing and transport, Biochem. J 147: 193–197.

    PubMed  CAS  Google Scholar 

  • Meyuhas, O., and Perry, R. P., 1979, Relationship between size, stability and abundance of the messenger RNA in mouse L cells, Cell 16: 139–148.

    Article  PubMed  CAS  Google Scholar 

  • Miller, T. E., Huang, C.-Y., and Pogo, A. O., 1978a, Rat liver nuclear skeleton and ribonucleoprotein complexes containing HnRNA, J. Cell Biol 76: 675–691.

    Article  CAS  Google Scholar 

  • Miller, T. E., Huang, C.-Y., and Pogo, A. O., 1978b, Rat liver nuclear skeleton and small molecular weight RNA species, J. Cell Biol 76: 692–704.

    Article  CAS  Google Scholar 

  • Moffett, R. B., and Webb, T. E., 1981, Regulated transport of messenger ribonucleic acid from isolated liver nuclei by nucleic acid binding proteins, Biochemistry 20: 3253–3262.

    Article  PubMed  CAS  Google Scholar 

  • Monneron, A., 1974, One-step isolation and characterization of nuclear membranes, Philos. Trans. R. Soc. London, Ser. B 268: 101–108.

    Article  CAS  Google Scholar 

  • Monneron, A., Blobel, G., and Palade, G. E., 1972, Fractionation of the nucleus by divalent cations, J. Cell Biol 55: 104–125.

    Article  PubMed  CAS  Google Scholar 

  • Murty, C. N., Verney, E. and Sidransky, H., 1976, Effect of tryptophan on polyriboadenylic acid and polyadenylic acid-messenger ribonucleic acid in rat liver, Lab. Invest 34: 77–85.

    PubMed  CAS  Google Scholar 

  • Murty, C. N., Verney, E., and Sidransky, H., 1977, The effect of tryptophan on nucleocytoplasmic translocation of RNA in rat liver, Biochim. Biophys. Acta 474: 117–128.

    PubMed  CAS  Google Scholar 

  • Murty, C. N., Verney, E., and Sidransky, H., 1979, In vivo and in vitro studies on the effect of tryptophan on translocation of RNA from nuclei in rat liver, Biochem. Med 22: 98–109.

    Article  PubMed  CAS  Google Scholar 

  • Murty, C. N., Verney, E., and Sidransky, H., 1980, Effect of tryptophan on nuclear envelope nucleoside triphosphatase in rat liver, Proc. Soc. Exp. Biol. Med 163: 155–161.

    PubMed  CAS  Google Scholar 

  • Murty, C. N., Verney, E., and Sidransky, H., 1982, Effect of tryptophan on nuclear envelope in rat liver: Evidence for increased nuclear RNA release, in: The Nuclear Envelope and the Nuclear Matrix (G. G. Maul, ed.), pp. 111–128, Wistar Symposium Series, Vol. 2, Alan R. Liss, New York.

    Google Scholar 

  • Nagel, W. C., and Wunderlich, F., 1977, Effect of temperature on nuclear membranes and nucleo-cytoplasmic RNA transport in Tetrahymena grown at different temperatures, J. Membr. Biol 32: 151–164.

    Article  PubMed  CAS  Google Scholar 

  • Narayan, K. S., Steele, W. J., Smetana, K., and Busch, H., 1967, Ultrastructural aspects of the ribonucleoprotein network in nuclei of Walker tumour and rat livers, Exp. Cell Res 46: 65–77.

    Article  PubMed  CAS  Google Scholar 

  • Nienhuis, A. W., Turner, P., and Benz, E. J., 1977, Relative stability of α- and β-globin messenger RNAs in homozygous β-thalassemia, Proc. Natl. Acad. Sci. U.S.A 74: 3960–3964.

    Article  PubMed  CAS  Google Scholar 

  • Nourse, L. D., Albrecht, C. F., and Van Zyl, I. M., 1974, Polysomal proteins in rat liver and DAB-1 hepatoma, S. Afr. J. Sci 70: 87.

    Google Scholar 

  • Paine, P. L., 1982, Mechanisms of nuclear protein concentration, in: The Nuclear Envelope and the Nuclear Matrix (G. G. Maul, ed.), pp. 75–84, Wistar Symposium Series, Vol. 2, Alan R. Liss, New York.

    Google Scholar 

  • Paine, P. L., and Horowitz, S. B., 1980, The movement of material between nucleus and cytoplasm, Cell Biol 4: 299–337.

    CAS  Google Scholar 

  • Paine, P. L., Moore, L. C., and Horowitz, S. B., 1975, Nuclear envelope permeability, Nature (London) 254: 109–114.

    Article  CAS  Google Scholar 

  • Paine, P. L., Pearson, T. W., Tluczek, L. J. M., and Horowitz, S. B., 1981, Nuclear sodium and potassium, Nature (London) 291: 258–261.

    Article  CAS  Google Scholar 

  • Palayoor, T., Schumm, D. E., and Webb, T. E., 1979, Active mRNA released from isolated nuclei in response to purified cytosol factors, Fed. Proc. Fed. Am. Soc. Exp. Biol 38: 908.

    Google Scholar 

  • Palayoor, T., Schumm, D. E., and Webb, T. E., 1981, Transport of functional messenger RNA from liver nuclei in a reconstituted cell-free system, Biochim. Biophys. Acta 654: 201–210.

    PubMed  CAS  Google Scholar 

  • Patel, N. T., Yoshida, M., and Holoubek, V., 1981, In vitroincorporation of 3’-methyl-4-dimethylaminoazobenzene into liver cell nuclei and release of RNA from the nuclei, Cancer Res 41: 743–751.

    PubMed  CAS  Google Scholar 

  • Pederson, T., 1974, Proteins associated with heterogeneous nuclear RNA in eukaryotic cells, J. Mol. Biol 83: 168–183.

    Article  Google Scholar 

  • Penman, S., 1981, The innermost network of the cell: The nuclear matrix and lamina, Presented at the Second Wistar Symposium, Philadelphia.

    Google Scholar 

  • Penman, S., Smith, I., and Holtzman, R., 1966, Ribosomal RNA synthesis and processing in a particulate site in the HeLa cell nucleus, Science 154: 786–789.

    Article  PubMed  CAS  Google Scholar 

  • Perry, R. P., 1976, Processing of RNA, Annu. Rev. Biochem 45: 605–629.

    Article  PubMed  CAS  Google Scholar 

  • Perry, R. P., Bard, E., Hames, B. D., Kelley, D. E., and Schibler, U., 1976, The relationship between hnRNA and mRNA, Prog. Nucleic Acid Res. Mol. Biol 19: 275–292.

    Article  PubMed  CAS  Google Scholar 

  • Peskin, A. V., Koen, Y. M., and Zbarsky, I. B., 1981, Some features of nucleocytoplasmic RNA transport from isolated nuclei, Mol. Biol. Rep 7: 25–30.

    Article  PubMed  CAS  Google Scholar 

  • Porteous, E. R., Jamieson, S. A., and Agutter, P. S., 1978, Instability of mammalian liver nuclear envelope nucleoside triphosphatase, Biochem. Soc. Trans 6: 1174–1177.

    PubMed  CAS  Google Scholar 

  • Poushchariov, V. M., and Doshchanov, Kh. I., 1981, The structure of messenger ribonuclear proteins transported from isolated nuclei of wheat embryos, Dokl. Akad. Nauk Ukrain. SSR Ser. B 3: 84–86.

    Google Scholar 

  • Poushchariov, V. M., Doshchanov, Kh. I., and Ajtkhozhin, M. A., 1981, Factors influencing the release of informosomes from isolated nuclei of wheat embryos in an in vitrosystem, Vestn. Akad. Nauk Kaz. SSR 1: 71–74.

    Google Scholar 

  • Puckett, L., Chambers, S., and Darnell, J. E., 1975, Short-lived messenger RNA in HeLa cells and its impact on the kinetics of accumulation of cytoplasmic polyadenylate, Proc. Natl. Acad. Sci. U.S.A 72: 389–393.

    Article  PubMed  CAS  Google Scholar 

  • Purrello, F., Vigneri, R., Clawson, G. A., and Goldfine, I. D., 1982, Insulin stimulation of nucleoside triphosphatase activity in isolated nuclear envelopes, Science 216: 1005–1007.

    Article  PubMed  CAS  Google Scholar 

  • Racevskis, J., and Webb, T. E., 1974, Processing and release of ribosomal RNA from isolated nuclei: Analysis of the ATP dependence and cytosol dependence, Eur. J. Biochem 49: 93–100.

    Article  PubMed  CAS  Google Scholar 

  • Ramirez de Guglielmone, A. E., and Duvilanski, B. H., 1977, RNA release from isolated brain cell nuclei: Influence of postnatal cerebral development, J. Neurosci. Res 3: 11–20.

    Article  PubMed  CAS  Google Scholar 

  • Ramirez de Guglielmone, A. E., Soto, A. M., and Duvilanski, B. H., 1974, Neonatal undernutrition and RNA synthesis in developing rat brain, J. Neurochem 22: 529–533.

    Article  Google Scholar 

  • Raskas, H. J., 1971, Release of adenovirus mRNA from isolated nuclei, Nature (London) New Biol 233: 134–135.

    Article  CAS  Google Scholar 

  • Raskas, H. J., and Bhaduri, S., 1973, Poly(adenylic acid) sequences in adenovirus ribonucleic acid released from isolated nuclei, Biochemistry 12: 920–925.

    Article  PubMed  CAS  Google Scholar 

  • Raskas, H. J., and Rho, Y.-C., 1973, ATP requirement for release of adenovirus mRNA from isolated nuclei, Nature (London) New Biol 245: 47–49.

    Article  CAS  Google Scholar 

  • Richardson, J. C. W., and Agutter, P. S., 1980, The relationship between the nuclear membranes and the endoplasmic reticulum in interphase cells, Biochem. Soc. Trans 8: 459–465.

    PubMed  CAS  Google Scholar 

  • Richardson, J. C. W., and Maddy, A. H., 1980, The polypeptides of rat liver nuclear envelope: I. Examination of nuclear pore complex polypeptides by solid-state lactoperoxidase labelling, J. Cell Sci 43: 253–267.

    PubMed  CAS  Google Scholar 

  • Rizzo, A. J., and Webb, T. E., 1969, Ribosome formation in rat liver: Evidence for post-transcriptional control, Biochim. Biophys. Acta 195: 109–122.

    PubMed  CAS  Google Scholar 

  • Ronsen, B., and Gordon, P., 1976, Methisoprinol enhancement of nucleocytoplasmic transport of putative messenger RNA in rat liver: Its relation to host defense against virus infection, Biochem. Pharmacol 25: 707–715.

    Article  PubMed  CAS  Google Scholar 

  • Rose, K. M., Jacob, S. T., and Kumar, A., 1979, Poly(A)polymerase and poly(A)-specific mRNA binding protein are antigenically related, Nature (London) 279: 260–262.

    Article  CAS  Google Scholar 

  • Ross, D. A., and Chae, C.-B., 1981, Mapping and characterization of the specific regions of globin nuclear RNA interacting with the nuclear matrix, Fed. Proc. Fed. Am. Soc. Exp. Biol 40: 1899.

    Google Scholar 

  • Roy, R. K., and Sarkar, S., 1980, Transcription, processing and release of RNA by isolated nuclei of the embryonic chick skeletal muscle, Eur. J. Cell Biol 22: 63.

    Google Scholar 

  • Roy, R. K., Lau, A. S., Munro, H. N., Baliga, B. S., and Sarkar, S., 1979, Release of in-vitro synthesized poly(A)-containing RNA from isolated rat liver nuclei: Characterization of the ribonucleoprotein particles involved, Proc. Natl. Acad. Sci. U.S.A 76: 1751–1755.

    Article  PubMed  CAS  Google Scholar 

  • Samal, B., and Bekhor, I., 1979, Kinetic estimation of the base sequence complexity of poly(A)-containing mRNA in Ehrlich ascites tumour cells and its abundance in nuclear RNA, Eur. J. Biochem 94: 51–57.

    Article  PubMed  CAS  Google Scholar 

  • Samarina, O. P., Krichevskaya, A. A., and Georgiev, G. P., 1966, Nuclear ribonucleoprotein particles containing messenger ribonucleic acid, Nature (London) 210: 1319–1322.

    Article  CAS  Google Scholar 

  • Sardana, M. K., and Padmanaban, G., 1976, Effect of 2-allyl-2-isopropylacetamide on poly(adenylic acid)-containing ribonucleic acid, Biochem. J 158: 169–174.

    PubMed  CAS  Google Scholar 

  • Sasaki, R., Goto, H., Armina, K., and Sasaki, Y., 1974, Effect of polyribonucleotides on eukaryotic DNA-dependent RNA polymerases, Biochim. Biophys. Acta 366: 435–442.

    PubMed  CAS  Google Scholar 

  • Sato, T., Ishikawa, K., and Ogata, K., 1977a, Characterization of nascent ribonucleoprotein particles released from isolated nuclei of regenerating rat liver in two different in vitro systems, Biochim. Biophys. Acta 474: 536–548.

    CAS  Google Scholar 

  • Sato, T., Ishikawa, K., and Ogata, K., 1977b, Factors causing release of ribosomal subunits from isolated nuclei of regenerating rat liver in vitro, Biochim. Biophys. Acta 474: 549–561.

    CAS  Google Scholar 

  • Sauermann, G., 1974, Nuclear columns: Release of ribonucleoproteins from rat liver nuclei, Biochem. Biophys. Res. Commun 56: 155–160.

    Article  PubMed  CAS  Google Scholar 

  • Scheer, U., 1973, Nuclear pore flow rate of ribosomal RNA and chain growth rate of its precursor during oogenesis of Xenopus laevis, Dev. Biol 30: 13–28.

    Article  PubMed  CAS  Google Scholar 

  • Scherrer, K., Latham, H., and Darnell, J. E., 1963, Demonstration of an unstable RNA and of a precursor to ribosomal RNA in HeLa cells, Proc. Natl. Acad. Sci. U.S.A 49: 240–248.

    Article  PubMed  CAS  Google Scholar 

  • Schlepper, J., and Knippers, R., 1975, Nuclear protein kinases from murine cells, Eur. J. Biochem 60: 209–220.

    Article  PubMed  CAS  Google Scholar 

  • Schneider, J. H., 1959, Factors affecting the release of nuclear ribonucleic acid from the nucleus in vitro, J. Biol. Chem 234: 2728–2732.

    PubMed  CAS  Google Scholar 

  • Schumm, D. E., and Webb, T. E., 1972, Transport of informosomes from isolated nuclei of regenerating rat liver, Biochem. Biophys. Res. Commun 48: 1259–1265.

    Article  PubMed  CAS  Google Scholar 

  • Schumm, D. E., and Webb, T. E., 1974a, The in vivo equivalence of a cell-free system for RNA processing and transport, Biochem. Biophys. Res. Commun 58: 354–360.

    Article  CAS  Google Scholar 

  • Schumm, D. E., and Webb, T. E., 1974b, Modified messenger ribonucleic acid release from isolated hepatic nuclei after inhibition of polyadenylate formation, Biochem. J 139: 191–196.

    CAS  Google Scholar 

  • Schumm, D. E., and Webb, T. E., 1975a, Differential effects of plasma fractions from normal and tumour-bearing rats on nuclear RNA restriction, Nature (London) 256: 508–509.

    Article  CAS  Google Scholar 

  • Schumm, D. E., and Webb, T. E., 1975b, Differential effects of plasma fractions from normal and tumour-bearing rats on nuclear RNA restriction, J. Natl. Cancer Inst 54: 123–128.

    CAS  Google Scholar 

  • Schumm, D. E., and Webb, T. E., 1975c, Differential effect of ATP on RNA and DNA release from nuclei of normal and neoplastic liver, Biochem. Biophys. Res. Commun 67: 706–713.

    Article  CAS  Google Scholar 

  • Schumm, D. E., and Webb, T. E., 1978, Effect of adenosine 3’:5’-monophosphate and guanosine 3’:5’-monophosphate on RNA release from isolated nuclei, J. Biol Chem 253:8513–8517.

    PubMed  CAS  Google Scholar 

  • Schumm, D. E., and Webb, T. E., 1980, Use of a cell-free system to study gene expression in normal and cancer cells, Vestn. Akad. Nauk SSSR 16: 45–50.

    Google Scholar 

  • Schumm, D. E., and Webb, T. E., 1981, Insulin-modulated transport of RNA from isolated liver nuclei, Arch. Biochem. Biophys 210: 275–279.

    Article  PubMed  CAS  Google Scholar 

  • Schumm, D. E., McNamara, D. J., and Webb, T. E., 1973a, Cytoplasmic proteins regulating messenger RNA release from nuclei, Nature (London) New Biol 245: 201–203.

    Article  CAS  Google Scholar 

  • Schumm, D. E., Morris, H. P., and Webb, T. E., 1973b, Cytosol-modulated transport of messenger RNA from isolated nuclei, Cancer Res 33: 1821–1828.

    CAS  Google Scholar 

  • Schumm, D. E., Hanausek-Walaszek, M., Yannarell, A., and Webb, T. E., 1977, Changes in nuclear RNA transport incident to carcinogenesis, Eur. J. Cancer 13: 139–147.

    PubMed  CAS  Google Scholar 

  • Schumm, D. E., Niemann, M. A., Palayoor, T., and Webb, T. E., 1979, In vivoequivalence of a cell-free system from rat liver for ribosomal RNA processing and transport, J. Biol. Chem 254:12,126–12,130.

    Google Scholar 

  • Schwartz, H., and Darnell, J. E., 1976, The association of protein with the polyadenylic acid of HeLa cell mRNA: Evidence for a “Transport” role of a 75,000 molecular weight polypeptide, J. Mol. Biol 104: 833–851.

    Article  PubMed  CAS  Google Scholar 

  • Schweiger, A., and Schmidt, D., 1974, Isolation of RNA-binding proteins from rat liver nuclear 30 S-particles, FEBS Lett 41: 17–19.

    Article  PubMed  CAS  Google Scholar 

  • Seifert, H., Scheurlen, M., Northemann, W., and Heinrich, P. C., 1979, Low molecular weight RNAs as components of nuclear ribonucleoprotein particles containing heterogeneous nuclear RNA, Biochim. Biophys. Acta 564: 55–66.

    PubMed  CAS  Google Scholar 

  • Shashiprobha, B. K., and Podder, S. K., 1978, Mode of action of antitumor antibiotics. III. Modulation of permeability of the nuclear membrane in the presence of the antibiotics, Biochem. Biophys. Res. Commun 83: 933–940.

    Article  Google Scholar 

  • Shearer, R. W., 1974a, Irreversibility of the alteration in RNA transport induced by an azo-dye carcinogen in the rat liver, Biochem. Biophys. Res. Commun 57: 604–613.

    Article  CAS  Google Scholar 

  • Shearer, R. W., 1974b, Specificity of chemical modification of ribonucleic acid transport by liver carcinogens in the rat, Biochemistry 13: 1764–1769.

    Article  CAS  Google Scholar 

  • Shearer, R. W., 1977, Differences and similarities in RNA regulation between tumours induced by chemicals and by DNA and RNA viruses, Vestn. Akad. Med. Nauk SSSR 3: 64–72.

    Google Scholar 

  • Shearer, R. W., 1979, Altered RNA transport without derepression in a rat kidney tumour induced by dimethylnitrosamine (single injection), Chem.-Biol. Interact 27: 91–98.

    Article  PubMed  CAS  Google Scholar 

  • Shearer, R. W., and Mayer, L. A., 1974, The heterogeneity of host gene transcription and transport of host RNA to the cytoplasm in polyoma virus-induced rat kidney tumors, Biochim. Biophys. Acta 335: 437–446.

    CAS  Google Scholar 

  • Shearer, R. W., and McCarthy, B. J., 1967, Evidence for ribonucleic acid molecules restricted to the nucleus, Biochemistry 6: 283–289.

    Article  PubMed  CAS  Google Scholar 

  • Shearer, R. W., and McCarthy, B. J., 1970, Characterization of RNA molecules restricted to the nucleus in mouse L cells, J. Cell Physiol 75: 97–107.

    Article  PubMed  CAS  Google Scholar 

  • Shearer, R. W., and Smuckler, E. A., 1972, Altered regulation of the transport of RNA from nucleus to cytoplasm in rat hepatoma cells, Cancer Res 32: 339–346.

    PubMed  CAS  Google Scholar 

  • Shelton, K. R., Higgins, L. L., Cochran, D. L., Ruffolo, J. J., and Egle, P. M., 1980, Nuclear lamins of erythrocyte and liver, J. Biol. Chem 255:10, 978–10, 983.

    Google Scholar 

  • Shepherd, G. W., and Flickinger, R., 1979, Post-transcriptional control of messenger RNA diversity in frog embryos, Biochim. Biophys. Acta 563: 413–421.

    PubMed  CAS  Google Scholar 

  • Sidransky, H., 1972, Chemical and cellular pathology of experimental acute amino acid deficiency, Methods Achiev. Exp. Pathol 6: 1–24.

    CAS  Google Scholar 

  • Sidransky, H., 1976, Nutritional disturbances of protein metabolism in the liver, Am. J. Pathol 84: 649–667.

    PubMed  CAS  Google Scholar 

  • Sidransky, H., and Verney, E., 1979, Effect of nutritional alterations on protein synthesis in transplantable hepatomas and host liver of rats, Cancer Res. 39: 1995–2000.

    PubMed  CAS  Google Scholar 

  • Sidransky, H., Verney, E., and Murty, C. N., 1974, Studies on mRNA of the livers of rats forcefed a threonine-devoid or complete diet, J. Nutr 104: 726–732.

    PubMed  CAS  Google Scholar 

  • Sidransky, H., Verney, E., and Murty, C. N., 1977, Effect of tryptophan on hepatic polyribosomes and protein synthesis in rats treated with carbon tetrachloride, Toxicol. Appl. Pharmacol 39: 295–305.

    Article  PubMed  CAS  Google Scholar 

  • Sidransky, H., Verney, H., and Murty, C. N., 1980, Studies on the influence of tryptophan and related compounds on hepatic polyribosomes and protein synthesis in the rat, J. Nutr 110: 2231–2242.

    PubMed  CAS  Google Scholar 

  • Sidransky, H., Verney, E., and Murty, C. N., 1981, Effect of tryptophan on hepatoma and host liver of rats: Influence after treatment with hypertonic sodium chloride and carbon tetrachloride, Exp. Mol. Pathol 35: 124–136.

    Article  PubMed  CAS  Google Scholar 

  • Siegal, G. P., Quinlan, T. J., Moses, H. L., and Getz, M. J., 1979, Frequency differences between nuclear and polysomal sequences of poly(A)-containing RNA from cultured AKR mouse embryo cells, J. Cell Physiol 98: 283–298.

    Article  PubMed  CAS  Google Scholar 

  • Singer, R. H., and Penman, S., 1973, Messenger RNA in HeLa cells: Kinetics of formation and decay. J. Mol. Biol 78: 321–334.

    Article  PubMed  CAS  Google Scholar 

  • Sippel, A. E., Hypes, N., Groner, B., and Schütz, G., 1977, Frequency distribution of messenger sequences within polysomal mRNA and nuclear RNA from rat liver, Eur. J. Biochem 77: 141–151.

    Article  PubMed  CAS  Google Scholar 

  • Smetana, K., Steele, W. J., and Busch, H., 1963, A nuclear ribonucleoprotein network, Exp. Cell Res 31: 198–201.

    Article  Google Scholar 

  • Smuckler, E. A., and Clawson, G. A., 1982, A model for nucleocytoplasmic transport of ribonucleoprotein particles, in: The Nuclear Envelope and the Nuclear Matrix (G. G. Maul, ed.), pp. 271–278, Wistar Symposium Series, Vol. 2, Alan R. Liss, New York.

    Google Scholar 

  • Smuckler, E. A., and Koplitz, M., 1973, Altered nuclear RNA transport associated with carcinogen intoxication in rats, Biochem. Biophys. Res. Commun 55: 499–506.

    Article  PubMed  CAS  Google Scholar 

  • Smuckler, E. A., and Koplitz, M., 1974, Thioacetamide-induced alterations in nuclear RNA transport, Cancer Res 34: 827–838.

    PubMed  CAS  Google Scholar 

  • Smuckler, E. A., and Koplitz, R. M., 1976, Polyadenylic acid content and electrophoretic behavior of in vitro released RNA’s in chemical carcinogenesis, Cancer Res 36: 881–888.

    PubMed  CAS  Google Scholar 

  • Spradling, A., Hui, H., and Penman, S., 1975, Two very different components of messenger RNA in an insect cell line, Cell 4: 131–137.

    Article  PubMed  CAS  Google Scholar 

  • Steele, W. J., and Busch, H., 1966, Studies on the ribonucleic acid component of the nuclear ribonucleoprotein network, Biochim. Biophys. Acta 129: 54–67.

    PubMed  CAS  Google Scholar 

  • Steer, R. C., Wilson, M. J., and Ahmed, K., 1979a, Protein phosphokinase activity of rat liver nuclear membrane, Exp. Cell Res 119: 403–406.

    Article  CAS  Google Scholar 

  • Steer, R. C., Wilson, M. J., and Ahmed, K., 1979b, Phosphoprotein phosphatase activity of rat liver nuclear membrane, Biochem. Biophys. Res. Commun 89: 1082–1087.

    Article  CAS  Google Scholar 

  • Steer, R. C., Goueli, S. A., Wilson, M. J., and Ahmed, K., 1980, Cobalt-stimulated protein kinase activity of the pore-complex-lamina fraction from rat liver nuclear envelope, Biochem. Biophys. Res. Commun 92: 919–925.

    Article  PubMed  CAS  Google Scholar 

  • Stevens, R. H., and Amos, H., 1971, RNA metabolism in HeLa cells at reduced temperatures. I. Modified processing of 45S RNA, J. Cell Biol 50: 818–829.

    Article  PubMed  CAS  Google Scholar 

  • Stevens, R. H., and Amos, H., 1972, RNA metabolism in HeLa cells at reduced temperature. II. Steps in the processing of transfer RNA, J. Cell Biol 54: 1–7.

    Article  PubMed  CAS  Google Scholar 

  • Stuart, S. E., Rottman, F. M., and Patterson, R. J., 1975, Nuclear restriction of nucleic acids in the presence of ATP, Biochem. Biophys. Res. Commun 62: 439–447.

    Article  PubMed  CAS  Google Scholar 

  • Stuart, S. E., Clawson, G. A., Rottman, F. M., and Patterson, R. J., 1977, RNA transport in isolated myeloma nuclei: Transport from membrane-denuded nuclei, J. Cell Biol 72: 57–66.

    Article  PubMed  CAS  Google Scholar 

  • Stubbs, G., and Harris, J. R., 1978, Peroxidase activity in rat liver nuclear envelope as a marker enzyme, Biochem. Soc. Trans 6: 1172–1174.

    PubMed  CAS  Google Scholar 

  • Therwath, A., and Scherrer, K., 1978, Post-transcriptional suppression of globin gene expression in cells transformed by avian erythroblastosis virus, Proc. Natl. Acad. Sci. U.S.A 75: 3776–3780.

    Article  PubMed  CAS  Google Scholar 

  • Tomkins, G. M., Gelehter, T. D., Granner, D., Martin, D., Samuels, H. H., and Thompson, E. B., 1969, Control of specific gene expression in higher organisms, Science 166: 1474–1480.

    Article  PubMed  CAS  Google Scholar 

  • Turner, W. A., Taylor, J. D., and Tchen, T. T., 1979, MSH stimulation of nuclear envelope blebbing, Pigment Cell 4: 50–55.

    Google Scholar 

  • Van Eekelen, C. A. G., and van Venrooij, W. J., 1981, Hn RNA and its attachment to a nuclear protein matrix, J. Cell Biol 88: 554–563.

    Article  PubMed  Google Scholar 

  • Van Eekelen, C. A. G., Riemen, T., and van Venrooij, W. J., 1981, Specificity of the interaction of HnRNA and mRNA with proteins as revealed by in vivocross linking, FEBS Lett 130: 223–226.

    Article  PubMed  Google Scholar 

  • Van Venrooij, W. J., and Janssen, D. B., 1978, HnRNP particles, Mol. Biol. Rep 4: 3–8.

    Article  PubMed  Google Scholar 

  • Van Venrooij, W. J., van Eekelen, C. A. G., Mariman, E. C. M., and Reinders, R. J., 1982, On the binding of host and viral RNA to a nuclear matrix, in: The Nuclear Envelope and the Nuclear Matrix (G. G. Maul, ed.), pp. 235–246, Wistar Symposium Series, Vol. 2, Alan R. Liss, New York.

    Google Scholar 

  • Van Voorthuizen, W. F., Dinsart, C., Flavell, R. A., de Vijlder, J. J. M., and Vassart, G., 1978, Abnormal cellular localization of thyroglobulin mRNA associated with hereditary congenital goitre and thyroglobulin deficiency, Proc. Natl. Acad. Sci. U.S.A 75:74–78.

    Article  PubMed  Google Scholar 

  • Van Zyl, I. M., 1974, Nuclear membranes in rat liver and DAB-1 hepatoma, S. Afr. J. Sci 70: 86–87.

    Google Scholar 

  • Vazquez-Nin, G. H., Echeverria, O. M., and Pedron, J., 1979, Effects of estradiol on the ribonucleoprotein constituents of the nucleus of cultured endometrial epithelial cells, Biol. Cell 35: 221–228.

    CAS  Google Scholar 

  • Vigneri, R., Goldfine, I. D., Wong, K. Y., Smith, G. J., and Pezzino, V., 1978, The nuclear envelope: The major site of insulin binding in rat liver nuclei, J. Biol. Chem 253: 2098–2103.

    PubMed  CAS  Google Scholar 

  • Vorbrodt, A., and Maul, G. G., 1980, Cytochemical studies on the relation of nucleoside triphosphatase activity to ribonucleoproteins in isolated rat liver nuclei, J. Histochem. Cytochem 28: 27–35.

    Article  PubMed  CAS  Google Scholar 

  • Webb, T. E., Schumm, D. E., and Palayoor, T., 1981, Nucleocytoplasmic transport of mRNA, in: The Cell Nucleus, Vol. IX ( H. H. Busch, ed.), pp. 199–247, Academic Press, New York.

    Google Scholar 

  • Weck, P. K., and Johnson, T. C., 1976, Nuclear-cytosol interactions that modulate RNA synthesis and transcript size of mouse brain nuclei, J. Neurochem 27: 1367–1374.

    Article  PubMed  CAS  Google Scholar 

  • Weck, P. K., and Johnson, T. C., 1978, Nuclear-cytosol interactions that facilitate release of RNA from mouse brain nuclei, J. Neurochem 30: 1057–1065.

    Article  PubMed  CAS  Google Scholar 

  • Wold, B. J., Klein, W. H., Hough-Evans, B. R., Britten, R. J., and Davidson, E. H., 1978, Sea urchin embryo mRNA sequences expressed in the nuclear RNA of adult tissues, Cell 14: 941–950.

    Article  PubMed  CAS  Google Scholar 

  • Wunderlich, F., 1972, The macronuclear envelope of Tetrahymena pyriformis in different physiological states. V. Nuclear pore complexes—a controlling system in protein biosynthesis?, J. Membr. Biol 7: 220–230.

    Article  Google Scholar 

  • Wunderlich, F., and Herlan, G., 1977, A reversibly contractile nuclear matrix: Its isolation, structure and composition, J. Cell Biol 73: 271–278.

    Article  PubMed  CAS  Google Scholar 

  • Wunderlich, F., Batz, W., Speth, V., and Wallach, D. F. H., 1974, Reversible thermotropic alteration of nuclear membrane structure and nucleo-cytoplasmic RNA transport in Tetrahymena, J. Cell Biol 61: 633–640.

    Article  PubMed  CAS  Google Scholar 

  • Wunderlich, F., Berezney, R., and Kleinig, H., 1976, The nuclear envelope: An interdisciplinary analysis of its morphology, composition and functions, in: Biological Membranes( D. Chapman and D. F. H. Wallach, eds.), pp. 241–333, Academic Press, New York.

    Google Scholar 

  • Wunderlich, F., Giese, G., and Bucherer, C., 1978, Expansion and apparent fluidity decrease of nuclear membranes induced by low Ca/Mg: Modulation of nuclear membrane lipid fluidity by the membrane-associated nuclear matrix proteins?, Exp. Cell Res 111: 479–490.

    Article  Google Scholar 

  • Yannarell, A., Schumm, D. E., and Webb, T. E., 1976, Nature of the facilitated messenger ribonucleic acid transport from isolated nuclei, Biochem. J 154: 379–385.

    PubMed  CAS  Google Scholar 

  • Yasuzumi, G., and Tsubo, I., 1966, The fine structure of nuclei as revealed by electron microscopy. III. Adenosine triphosphatase activity in the pores of the nuclear envelope of mouse choroid plexus epithelial cells, Exp. Cell Res 43: 281–292.

    Article  PubMed  CAS  Google Scholar 

  • Yasuzumi, G., Nakai, Y., Tsubo, L, Yasuda, M., and Sugioka, T., 1967, The fine structure of nuclei as revealed by electron microscopy. IV. The intranuclear inclusion formation in Leydig cells of aging human testes, Exp. Cell Res 45: 261–276.

    Article  PubMed  CAS  Google Scholar 

  • Yu, L.-C., Racevskis, J., and Webb, T. E., 1972, Regulated transport of ribosomal subunits from regenerating rat liver nuclei in a cell-free system, Cancer Res 32:2314–2321.

    PubMed  CAS  Google Scholar 

  • Zbarsky, I. B., 1972, Association of nuclear envelope with cytoplasmic structures and mechanisms of nuclear-cytoplasmic interrelationships, Usp. Sovrem. Biol 73: 3–25.

    Google Scholar 

  • Zbarsky, I. B., 1978, An enzyme profile of the nuclear envelope, Int. Rev. Cytol 54: 295–360.

    Article  PubMed  CAS  Google Scholar 

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  1. Department of Biological Sciences, Napier College, Edinburgh, EH10 5DT, UK

    Paul S. Agutter

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    Donald B. Roodyn

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Agutter, P.S. (1984). Nucleocytoplasmic RNA Transport. In: Roodyn, D.B. (eds) Subcellular Biochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2709-7_5

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