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Morphological Measurements in the Aging Rat Cerebral Cortex

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Abstract

This chapter deals with the structural changes seen in the brains of aging rats exposed to differential environments. We have previously reviewed the overall progress of experiments from our laboratory indicating brain changes due to modified external stimuli (Diamond and Connor, 1981, 1982). We showed changes in occipital cortical cell number and pyramidal cell dendrites from animals living in enriched, standard colony, and impoverished conditions. The present chapter includes some of the same data, but adds new information from the somatosensory cortex which has more recently been obtained. New dendritic spine data have also been presented to compare with our previous work.

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References

  • Brizzee, K. R., Sherwood, N., and Timiras, P. S., 1968, A comparison of various depth levels in cerebral cortex of young adults and aged Long-Evans rats, J. Gerontol. 23:289–297.

    PubMed  CAS  Google Scholar 

  • Buell, S., and Coleman, P., 1979, Dendritic growth in the aged human brain and failure of growth in senile dementia, Science 206:854–856.

    Article  PubMed  CAS  Google Scholar 

  • Connor, J. R., Jr., 1981, Environmental influences on aging brain morphology, Ph.D. thesis, Department of Physiology-Anatomy, University of California, Berkeley, California.

    Google Scholar 

  • Connor, J. R., and Diamond, M. C., 1982, A comparison of dendritic spine number and type on pyramidal neurons of the visual cortex of old adult rats from social or isolated environments, J. Comp. Neurol. 210:99–106.

    Article  PubMed  CAS  Google Scholar 

  • Connor, J. R., Diamond, M. C., and Johnson, R. E., 1980a, Occipital cortical morphology of the rat: Alteration with age and environment, Exp. Neurol. 68:158–170.

    Article  Google Scholar 

  • Connor, J. R., Diamond, M. C., and Johnson, R. E., 1980b, Aging and environmental influence on two types of dendritic spines in the rat occipital cortex, Exp. Neurol. 70:371–379.

    Article  Google Scholar 

  • Connor, J. R., Diamond, M. C., Connor, J. A., and Johnson, R. E., 1981a, A Golgi study of dendritic morphology in the occipital cortex of socially reared aged rats, Exp. Neurol. 73:525–533.

    Article  CAS  Google Scholar 

  • Connor, J. R., Melone, J. H., Yuen, A. R., and Diamond, M. C., 1981b, Dendritic length in aged rats’ occipital cortex: An environmentally induced response, Exp. Neurol. 73:827–830.

    Article  CAS  Google Scholar 

  • Connor, J. R., Beban, S. E., Hopper, P. A., Hansen, B., and Diamond, M. C., 1982a, A Golgi study of the superficial pyramidal cells in the somatosensory cortex of socially reared old adult rats, Exp. Neurol. 76:35–45.

    Article  CAS  Google Scholar 

  • Connor, J. R., Beban, S. E., Melone, J. H., Yuen, A., and Diamond, M. C., 1982b, A quantitative Golgi study in the occipital cortex of pyramidal dendritic topology of old adult rats from social or isolated environments, Brain Res. 251:39–44.

    Article  CAS  Google Scholar 

  • Connor, J. R., Wang, E. C., and Diamond, M. C., 1982c, Increased length of terminal dendritic segments in old rats’ somatosensory cortex: An environmentally induced response, Exp. Neurol. 78:466–470.

    Article  CAS  Google Scholar 

  • Diamond, M. C., 1976, Anatomical brain changes induced by environment, in: Knowing, Thinking, and Believing( J. McGaugh and L. Petrinovich, eds.), Plenum Press, New York, pp. 215–241.

    Google Scholar 

  • Diamond, M. C., and Connor, J. R., Jr., 1981, A search for the potential of the aging brain, in: Brain Neurotransmitters and Receptors in Aging and Age-Related Disorders( S. Enna, T. Samorajski, and B. Beer, eds.), Raven Press, New York, pp. 43–58.

    Google Scholar 

  • Diamond, M. C., and Connor, J. R., 1982, Plasticity of the aging cerebral cortex, in: Physiological and Pathophysiological Aspects of the Aging Brain( S. Hoyer, ed.), Springer-Verlag, New York, pp. 36–44.

    Google Scholar 

  • Diamond, M. C., Law, F., Rhodes, H., Lindner, B., Rosenzweig, M., Krech, D., and Bennett, E. L., 1966, Increases in cortical depth and glia numbers in rats subjected to enriched environments, J. Comp. Neurol. 128:117–126.

    Article  PubMed  CAS  Google Scholar 

  • Diamond, M. C., Johnson, R. E., and Gold, M. W., 1977, Changes in neuron and glia number in the young, adult, and aging rat occipital cortex, Behav. Biol. 20:409–418.

    Article  PubMed  CAS  Google Scholar 

  • Feldman, M. L., 1976, Aging changes in the morphology of cortical dendrites, in: Neurobiology of Aging( R. D. Terry and S. Gershon, eds.), Raven Press, New York, pp. 221–227.

    Google Scholar 

  • Hinds, J. W., and McNelly, N. A., 1977, Aging of the rat olfactory bulb: Growth and atrophy of constituent layers and changes in size and number of mitral cells, J. Comp. Neurol. 171:345–369.

    Article  Google Scholar 

  • Holloway, R. L., 1966, Increased dendritic branching in layer II stellate neurons of occipital cortex as compared to deprived littermates, Brain Res. 2:393–396.

    Article  PubMed  Google Scholar 

  • Miller, M., and Peters, A., 1981, Maturation of rat visual cortex. II. Electron microscopic study of pyramidal neurons, J. Comp. Neurol. 203:555–573.

    Article  PubMed  CAS  Google Scholar 

  • Minot, C. S., 1908, The Problem of Age, Growth, and Death, G. P. Putnam’s Sons, New York.

    Google Scholar 

  • Scheibel, M. E., Lindsay, R. D., Tomiyasu, U., and Scheibel, A. B., 1975, Progressive dendritic changes in aging human cortex, Exp. Neurol. 47:392–403.

    Article  PubMed  CAS  Google Scholar 

  • Valverde, F., 1970, The Golgi method: A tool for comparative structural analyses, in: Contemporary Research Methods in Neuroanatomy( W. J. H. Nauta and S. O. E. Ebbesson, eds.), Springer- Verlag, New York, pp. 12–28.

    Google Scholar 

  • Van der Loos, H., 1959, Dendro-dendritische Verbindingen in de Schors der Grote Hersenen, H. Stam, Haarlem.

    Google Scholar 

  • Yakovlev, P. I., and Lecours, A. R., 1967, The myelogentic cycles of regional maturation of the brain, in: Development of the Brain in Early Life (A. Minkowski, ed.), Blackwell Scientific Publications, Oxford, Edinburgh, pp. 3–70.

    Google Scholar 

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© 1984 Plenum Press, New York

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Diamond, M.C., Connor, J.R. (1984). Morphological Measurements in the Aging Rat Cerebral Cortex. In: Scheff, S.W. (eds) Aging and Recovery of Function in the Central Nervous System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2705-9_3

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  • DOI: https://doi.org/10.1007/978-1-4613-2705-9_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9680-5

  • Online ISBN: 978-1-4613-2705-9

  • eBook Packages: Springer Book Archive

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