Formation of Heterocyclic Compounds
Whereas the formation of carbon—carbon bonds using transition metal intermediates has been relatively well studied, the synthesis of heterocyclic compounds using transition metals has attracted much less attention. Indeed in recent years only two reviews on the subject have appeared.1 As the demand for new heterocyclic compounds increases, particularly for pharmaceutical and crop protection chemicals, then the use of transition metal species might well offer advantages over the more conventional routes in terms of milder reaction conditions, better selectivity, novel synthetic routes, or the use of more readily available starting materials. Already attractive new routes to known compounds have been discovered using transition metal catalysts. One area which could be commercially important, for example, is the cobalt-catalyzed synthesis of pyridines from acetylenes and nitriles.2
KeywordsSchiff Base Heterocyclic Compound Catalytic Amount Nitrogen Heterocycle Rhodium Catalyst
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