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Donation Procedure: Collection Lesion, Fibrinopeptide A, and Factor VIII

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Plasma Fractionation and Blood Transfusion

Part of the book series: Developments in Hematology and Immunology ((DIHI,volume 13))

Abstract

Following the work of Pflugshaupt (1) a number of groups, including ourselves have re-investigated the effects of donation procedures on the quality of plasma destined for preparation of factor VIII concentrates. The Swiss group argued that thrombin formation in donated blood might have two adverse effects on the quality of plasma; firstly degradation of factor VIII yielding a more labile product, and secondly generation of fibrin resulting in a less soluble product, if this protein forms part of the final factor VIII concentrate. Using fibrinopeptide A (FpA) levels as a measure of the presence of thrombin, they confirmed that plasma containing more than 50 ng/ml FpA resulted in a poorly soluble and labile product when the factor concentrate was made by their technique. It was also shown that an improved donation procedure could reduce plasma FpA levels.

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References

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Authors
  1. C. V. Prowse
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Editors and Affiliations

  1. Red Cross Blood Bank Groningen-Drenthe, Groningen, The Netherlands

    C. Th. Smit Sibinga  & P. C. Das  & 

  2. Red Cross Blood Transfusion Service Hessen, Frankfurt am Main, Germany

    S. Seidl

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© 1985 Martinus Nijhoff Publishing, Boston

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Prowse, C.V. (1985). Donation Procedure: Collection Lesion, Fibrinopeptide A, and Factor VIII. In: Smit Sibinga, C.T., Das, P.C., Seidl, S. (eds) Plasma Fractionation and Blood Transfusion. Developments in Hematology and Immunology, vol 13. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2631-1_4

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  • DOI: https://doi.org/10.1007/978-1-4613-2631-1_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9644-7

  • Online ISBN: 978-1-4613-2631-1

  • eBook Packages: Springer Book Archive

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