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Clinical Use of Polyelectrolyte-Fractionated Porcine Factor VIII

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Plasma Fractionation and Blood Transfusion

Part of the book series: Developments in Hematology and Immunology ((DIHI,volume 13))

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Abstract

There is no shortage of animal plasma and, in several species, plasma factor VIII levels are higher than they are in man — in the case of pigs, about five times higher (1). These advantages were recognised by Dr. Ethel Bidwell and her colleagues, who prepared the first animal factor VIII concentrates for intravenous human therapeutic use in the early 1950’s (2).

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References

  1. Bennett B, Ratnoff WD: Immunologic relationships of antihemophilic factor of different species detected by specific human and rabbit antibodies. Proc Soc Biol Med 1973; 143: 701–6.

    CAS  Google Scholar 

  2. Bid well E: The purification of antihaemophilic globulin from animal plasma. Br J Haematol 1955; 1: 386–9.

    Article  CAS  Google Scholar 

  3. Middleton S: Polyelectrolytes and preparation of factor VIIIC. In: Forbes CD, Lowe GDO, eds. Unresolved problems in haemophilia. Lancaster. MTP Press, 1982: 109–20.

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  4. Kernoff PBA, Thomas ND, Lilley PA, Matthews KB, Goldman E, Tuddenham EGD: Clinical experience with polyelectrolyte-fractionated porcine factor VIII concentrate in the treatment of hemophiliacs with antibodies to factor VIII. Blood 1984; 63: 31–41.

    PubMed  CAS  Google Scholar 

  5. Kernof PBA: Porcine factor VIII: preparation and use in treatment of inhibitor patients. In: Hoyer LW, ed. Factor VIII inhibitors. New York, Alan R. Liss 1984: 207–24.

    Google Scholar 

  6. Galpin SA, Karayiannis P, Middleton SM, Thomas HC: The removal of hepatitis B virus from factor VIII concentrates by fractionation on ethylene maleic anhydride polyelectrolyte. J Med Virol: 1984; 14: 229–33.

    Article  PubMed  CAS  Google Scholar 

  7. Wensley RT, Delamore IW, Burn AM, Cottrell S, Maugham L: The use of porcine factor VIII concentrate to cover major surgery in a mildly affected haemophiliac. Proc XVI Cong Wrld Fed Hemophilia 1984:19 (Abstr).

    Google Scholar 

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© 1985 Martinus Nijhoff Publishing, Boston

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Kernoff, P.B.A. (1985). Clinical Use of Polyelectrolyte-Fractionated Porcine Factor VIII. In: Smit Sibinga, C.T., Das, P.C., Seidl, S. (eds) Plasma Fractionation and Blood Transfusion. Developments in Hematology and Immunology, vol 13. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2631-1_25

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  • DOI: https://doi.org/10.1007/978-1-4613-2631-1_25

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9644-7

  • Online ISBN: 978-1-4613-2631-1

  • eBook Packages: Springer Book Archive

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