Abstract
Human T-cell leukemia virus type I (HTLV-I) has been strongly implicated as the etiology of adult T-cell leukemia (ATL) (1–7), a T-cell type non-Hodgkin’s lymphoma with leukemic manifestations in Japan, the Caribbean, and the southeastern United States (1–7). The prevalence of serum antibody specific for one core antigen of HTLV-I, p24, has been found to be high in patients with ATL (7–9), and higher in relatives of these patients than in general population controls (7–9). Reported population prevalences of p24 antibody have varied from less than 1% for U.S. and Japanese populations (7,8) to 3% for Caribbean populations (10). When antibody to another HTLV-I core antigen, pl9, was evaluated, 0.5% of Washington D.C. participants, 1.9% of Georgia participants, 1.5% of Japanese participants from ATL non-endemic areas, and 11.9% of Japanese participants from ATL-endemic areas demonstrated antibodies to one of these core antigens (9). Recent findings suggest that HTLV-I is readily transmissible through cellular blood products (11,12), but not through iyophilized factor concentrates (13).
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References
Blattner WA, Blayney DW, Robert-Guroff M, et al. Epidemiology of human T-cell leukemia/lymphoma virus. J Infect Dis 1983; 147: 406–16.
Akagi T, Ohtsuki Y, Takahashi K, et al. Detection of type C virus particles in short-term cultured adult T-cell leukemia cells. Lab Invest 1982; 47: 406–8.
Hinuma Y, Gotoh Y-I, Sugamura K, et al. A retrovirus ’associated with human adult T-cell leukemia: in vitro activation. Gann 1982; 73: 341–4.
Gallo RC, Blattner WA, Reitz MS, et al. HTLV: the virus of adult T-cell leukaemia in Japan and elsewhere. Lancet 1982;i:683.
Blayney DW, Jaffe ES, Blattner WA, et al. The human T-cell leukemia/lymphoma virus associated with American adult T-cell leukemia/lymphoma. Blood 1983; 62: 401–5.
Popovic M, Sarin PS, Robert-Guroff M, et al. Isolation and transmission of human retrovirus (human T-cell leukemia virus). Science 1983; 219: 856–9.
Kalyanaraman VS, Sarngadharan MG, Bunn PA, et al. Antibodies in human sera reactive against an internal structural protein of human T-cell lymphoma virus. Nature 1981; 294: 271–3.
Kalyanaraman VS, Sarngadharan MG, Nakas Y, et al. Natural antibodies to the structural core protein (p24) of the human T-cell leukemia (lymphoma) retrovirus found in sera of leukemia patients in Japan. Proc Natl Acad Sci U.S.A. 1982; 79: 1653–7.
Robert-Guroff M, Kalynaraman VS, Blattner WA, et al. Evidence for human T-cell lymphoma-leukemia virus infection of family members of human T-cell leukemia lymphoma-virus positive T-cell leukemia-lymphoma patients. J Exp. Med 1983; 157: 248–58.
Schupbach J, Kalyanaraman VS, Sarngadharan MG, et al. Antibodies against three purified proteins of the human type C retrovirus, human T-cell leukemia-lymphoma virus, in adult T-cell leukemia-lymphoma patients and healthy blacks from the Caribbean. Cancer Res 1983; 43: 886–91.
Yamamoto H, Tometa N, Ishi A, etal. Blood products from anti-ATLA positive donors transform anti-ATLA negative leukocytes in vitro. Cancer Res, in press.
Okochi K, Sato H, Hinuma Y. A retrospective study on transmission of adult T-cell leukemia virus by blood transfusion: seroconversion in recipients. Vox Sang 1983; 46: 245–53.
Chorba T, Jason J, Ramsey R, etal. Serosurveys for evidence of exposure to human T-cell leukemia virus (HTLV-I) in European and American hemophilia patients treated with factor concentrates prepared from U.S. plasma sources and in hemophilia patients treated with factor concentrates prepared from U.S. plasma sources and in hemophilia patients with acquired immunodeficiency syndrome. Thromb Haemostas, in press.
Saxon A, Stevens RH, Golde DW. T-lymphocyte variant of hairy-cell leukemia. Ann Intern Med 1978; 88: 323– 6.
Saxon A, Stevens RH, Quan SG, et al. Immunologic characterization of hairy-cell-leukemias in continuous culture. J. Immunol 1978; 120: 777–82.
Hahn BH, Popovic M, Kalyanaraman VS, et al. Detection and characterization of an HTLV-II provirus in a patient with AIDS. In: Gottlien MS, Groopman JE, eds. Acquired immune deficiency syndrome. New York, Alan R. Liss, 1984; 73–81.
Chorba T, Brynes R, Telfer M, et al. Characterization of T-lymphocytes infected by a novel isolate of human T-leukemia virus type II (HTLV-II). Blood 1984; 5 (suppl 1), 201a.
Evatt BL, Stein SF, Francis DP, et al. Antibodies to human T-cell leukaemia virus-associated membrane antigens in haemophiliacs: Evidence for infection before 1980. Lancet 1983;ii:698–701.
Gallo RC, Sarin PS, Gelmann EP, et al. Isolation of human T-cell leukemia virus in acquired immunodeficiency syndrome (AIDS). Science 1983; 220: 865–7.
Miyoshi I, Kobayashi M, Yoshimoto S, et al. ATLV in Japanese patient with AIDS (Letter). Lancet 1983;ii:275.
Popovic M, Sarngadharan MG, Read E, et al. Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS. Science 1984; 224: 487–500.
Klatzman D, Barre-Sinoussi F, Negeyre MT, et al. Selective tropism of lymphadenopathy-associated virus (LAV) for helper-inducer T lymphocytes. Science 1984; 225: 59–63.
Jason J, Hilgartner M, Holman RC, et al. Immune status of blood product recipients. JAMA, 1985; 253: 1140–5.
Tsang VCW, Peralta JM, Simons AR. The enzyme-linked immuno- electro-transfer blot techniques (EITB) for studying the specificities of antigens and antibodies separated by gel electrophoresis. Methods Enzymol 1983; 92: 377–91.
Kalyanaraman VS, Sarngadharan MG, Poiesz BJ, et al. Immunological properties of a type C retrovirus isolated from cultured human T-lymphoma cells and comparison to other mammalian retroviruses. J. Virol 1981; 38: 906–15.
Barre-Sinoussi F, Chermann JC, Rey F, et al. Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immunodeficiency (AIDS). Science 1983; 220: 868–71.
Fessain A, Gazzolo L, Yoyo M, et al. Sickle-cell anaemia patients from Martinique have an increased prevalence of HTLV-I antibodies. Lancet 1984;i: 1155–6.
Clapham P, Nagy K, Cheingsong-Popov R, et al. Productive infection and cell-free transmission of human T-cell leukemia virus in an non-lympoid cell line. Science 1983; 222: 1125–7.
Miyoshi I, Taguchi H, Kubonishi I, et al. Type C virus-producing cell lines derived from adult T-cell leukemia. In: Hanaoka M, Takatsuki K, Shimoyama M, eds. Adult T-cell leukemia and related diseases. New York, Plenum Press, 1982; 219–28.
Yamamoto N, Schneider J, Koyanagi Y, et al. Adult T-cell leukemia (ATL) virus-specific antibodies in ATL patients and healthy virus carriers. Int J Cancer 1983; 32: 281–7.
Lee CA, Kernoff PBA, Bofill M, et al. HTLV and hemophilia. Lancet 1984;i: 1028.
Gelmann EP, Popovic M, Blayney D, et al. Proviral DNA of a retrovirus, human T-cell leukemia virus, in two patients with AIDS. Science 1983; 220: 862–5.
Essex M, McLane MF, Lee TH, et al. Antibodies to cell membrane antigens associated with human T-cell leukemia virus in patients with AIDS. Science 1983; 220: 860–2.
Essex M, McLane MF, Lee TH, et al. Antibodies to human T-cell leukemia virus membrane antigens (HTLV-MA) in hemophiliacs. Science 1983; 221: 1061 - 4.
Black PH, Levy EM. The human T-cell leukemia virus and AIDS. N Engl J Med 1983; 309: 856.
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© 1985 Martinus Nijhoff Publishing, Boston
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Chorba, T.L., Jason, J.M., McDougal, J.S. (1985). HTLV-I/II and HTLV-III Seroprevalence in Blood Product Recipients. In: Smit Sibinga, C.T., Das, P.C., Seidl, S. (eds) Plasma Fractionation and Blood Transfusion. Developments in Hematology and Immunology, vol 13. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2631-1_20
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DOI: https://doi.org/10.1007/978-1-4613-2631-1_20
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