Destruction of Tumor Cells by Macrophages: Mechanisms of Recognition and Lysis and Their Regulation

  • Scott D. Somers
  • William J. Johnson
  • Dolph O. Adams
Part of the Cancer Treatment and Research book series (CTAR, volume 27)


Mononuclear phagocytes, located throughout all tissues of the body, serve a multitude of major defensive and homeostatic functions [1]. One of the most important functions is the pivotal role macrophages can play in host protection against the development and spread of neoplasia [2]. Yet, the consistent and successful immunotherapy of human cancer remains an elusive goal [3]. Understanding the complex mechanisms regulating macrophage-mediated tumor cell destruction may ultimately lead to a rational basis for immunomodulation and, hence, successful immunologically based therapy of neoplastic diseases.


Peritoneal Macrophage Human Monocyte Phorbol Myristate Acetate Murine Macrophage Selective Binding 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Martinus Nijhoff Publishers, Boston 1986

Authors and Affiliations

  • Scott D. Somers
  • William J. Johnson
  • Dolph O. Adams

There are no affiliations available

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