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The Epidemiology of Epstein-Barr Virus-Associated Malignancies

  • P. H. Levine
Part of the Developments in Medical Virology book series (DIMV, volume 1)

Summary

Epidemiologic studies of Epstein-Barr Virus (EBV)-associated malignancies continue to demonstrate the interrelationship of multiple etiologic factors, thereby allowing several opportunities for intervention with the disease process. For the two malignancies most closely linked with EBV, Burkitt’s lymphoma (BL) and nasopharyngeal carcinoma (NPC), the risk factors are more readily identified in high-incidence areas than in low-incidence areas. The report of an apparent decline in BL incidence in Africa is in contrast with a reported increase in incidence among young white males in the United States. The search for etiologic factors in BL, in addition to EBV and malaria, is currently focusing on retroviruses. For NPC, evidence continues to support the major roles of genetics and salted fish in southern Chinese, but other etiologic factors appear to be important in non-Chinese. In areas of low incidence for BL and NPC, less homogeneous patterns are seen suggesting the inclusion of unrelated cases. Precise definition of study groups may be aided by new laboratory assays. The further development and utilization of cancer registry data throughout the world will also increase our knowledge of these diseases.

Keywords

Nasopharyngeal Carcinoma Multiple Etiologic Factor Young White Male Lymphoma Registry 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Martinus Nijhoff Publishing, Boston 1985

Authors and Affiliations

  • P. H. Levine
    • 1
  1. 1.Clinical Epidemiology BranchNational Cancer InstituteBethesdaUSA

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