Monocyte Contrasuppression of EBV-Immune Regulatory T Cells

  • G. Tosato
  • S. E. Pike
  • R. M. Blaese
Part of the Developments in Medical Virology book series (DIMV, volume 1)

Summary

EBV-immune normal individuals have circulating regulatory T cells that inhibit the activation of autologous B cells by EBV. When T cells were fractionated in subsets enriched for either T8 or T4 expressing lymphocytes and subsequently cultured with autologous EBV-infected cells, most of the inhibitory activity derived from T8-enriched populations. Monocyte depletion of EBV immune autologous B and T cells was associated with an enhanced degree of T-cell inhibition. Conversely, monocyte reconstitution of monocyte-depleted cultures markedly reduced EBV-immune T-cell suppression. Thus, in an EBV-specific system of suppression, monocytes act as regulatory cells with “contrasuppressor” function.

Keywords

Carbonyl Interferon 

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Copyright information

© Martinus Nijhoff Publishing, Boston 1985

Authors and Affiliations

  • G. Tosato
    • 1
  • S. E. Pike
    • 1
  • R. M. Blaese
    • 2
  1. 1.FDABethesdaUSA
  2. 2.NIHBethesdaUSA

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