Monocyte Contrasuppression of EBV-Immune Regulatory T Cells
EBV-immune normal individuals have circulating regulatory T cells that inhibit the activation of autologous B cells by EBV. When T cells were fractionated in subsets enriched for either T8 or T4 expressing lymphocytes and subsequently cultured with autologous EBV-infected cells, most of the inhibitory activity derived from T8-enriched populations. Monocyte depletion of EBV immune autologous B and T cells was associated with an enhanced degree of T-cell inhibition. Conversely, monocyte reconstitution of monocyte-depleted cultures markedly reduced EBV-immune T-cell suppression. Thus, in an EBV-specific system of suppression, monocytes act as regulatory cells with “contrasuppressor” function.
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