Unusual Primary Tumors of Brain and Lungs Associated with Epstein-Barr Virus (EBV)
The association of African Burkitt’s lymphoma (BL) and nasopharyngeal carcinoma (NPC) with EBV is well known. Opportunistic EBV associated polymorphic B cell lymphoma have also been observed in renal transplant patients (Hanto et al., 1983) and in bone marrow transplant patients (Starzl et al., 1984). Similar tumors in congenital or acquired immunodeficiency syndromes have rarely been reported (Saemundsen et al., 1981; Reece etal., 1981; Blanc et al., 1984). Such tumors have also been reported very rarely in apparently normal individuals (Hochberg et al., 1983). We have recently seen a primary monoclonal polymorphic B cell lymphoma of the brain in a 3 year old girl with congenital combined immunodeficiency associated with adenosine deaminase deficiency, a similar lung lymphoma in a 4 year old girl with acute lymphocytic leukemia in remission and a primary non keratinizing squamous cell carcinoma of the lingula in a 43 year old women, all associated with EBV.
KeywordsFormaldehyde Lymphoma Leukemia Adenosine Penicillin
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