Epstein-Barr Virus (EBV) Growth Transformation is Associated with an Alteration in c-myc Chromatin Structure

  • William H. Schubach
  • Bart H. Steiner
  • Mark Birkenbach
Part of the Developments in Medical Virology book series (DIMV, volume 1)


Because the c-myc gene is involved in translocations in Burkitt’s lymphoma, and because of the association of this neoplasm with EBV infection, we have studied the chromatin structure of the c-myc gene in EBV growth-transformed cells and in an isogenic population of cells enriched for B-cells. No correlation between the location of DNaseI-hypersensitive sites and translocation breakpoints in c-myc was found. A novel DNaseI-hypersensitive site appears within the second c-myc intron of growth-transformed cells that is absent in nontransformed cells. In contrast, the pattern of nuclease sensitivity around the pro-α-2-collagen gene is identical in both cells. Thus some gene product encoded or induced in EBV transformed cells may serve to alter chromatin structure in c-myc. This alteration might play a role in controlling c-myc expression in growth-transformed cells.


Chromatin Structure Nontransformed Cell Translocation Breakpoint Hypersensitive Site Avian Leukosis Virus 
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Copyright information

© Martinus Nijhoff Publishing, Boston 1985

Authors and Affiliations

  • William H. Schubach
    • 1
  • Bart H. Steiner
    • 1
  • Mark Birkenbach
    • 2
  1. 1.Department of MedicineSection of Medical OncologyUSA
  2. 2.Department of Laboratory Medicine and PathologyUniversity of MinnesotaMinneapolisUSA

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