Effects of Tunicamycin on Binding of Epstein-Barr Virus
The effects of tunicamycin were examined on the production of lytic and transforming strains of Epstein- Barr virus (EBV). The drug altered expression of EBV membrane antigens on the surface of producer cells and markedly reduced the yield of virus. The small amount of virus that was released was still able to bind to receptor positive cells, but its ability to induce immunoglobulin synthesis in normal B cells was compromised.
KeywordsSpend Culture Medium Extracellular Virus Receptor Positive Cell Nucleic Acid Spot Hybridization Indirect Immuno
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