Effects of Tunicamycin on Binding of Epstein-Barr Virus

  • N. Balachandran
  • L. M. Hutt-Fletcher
Part of the Developments in Medical Virology book series (DIMV, volume 1)


The effects of tunicamycin were examined on the production of lytic and transforming strains of Epstein- Barr virus (EBV). The drug altered expression of EBV membrane antigens on the surface of producer cells and markedly reduced the yield of virus. The small amount of virus that was released was still able to bind to receptor positive cells, but its ability to induce immunoglobulin synthesis in normal B cells was compromised.


Spend Culture Medium Extracellular Virus Receptor Positive Cell Nucleic Acid Spot Hybridization Indirect Immuno 
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Copyright information

© Martinus Nijhoff Publishing, Boston 1985

Authors and Affiliations

  • N. Balachandran
    • 1
  • L. M. Hutt-Fletcher
    • 1
  1. 1.Dept. of Comp & Exp. PathologyUniversity of Florida GainesvilleUSA

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