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Relapsing, Recurrent, and Chronic Infectious Mononucleosis in the Normal Host

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Part of the book series: Developments in Medical Virology ((DIMV,volume 1))

Abstract

Infectious mononucleosis is a well described disorder, so there is no need for me to review the features of the classic syndrome or the extensive evidence for Epstein-Barr virus (EBV) as its major cause. I will, instead, review a number of selected aspects of infectious mononucleosis that have occupied my attention for the past few years, but which are incompletely addressed in the literature. These include the rather provocative issues of relapse, recurrence, and chronicity of EBV infection in the normal host.

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References

  • ASKINAZI, C., COLE, F.S., and BRUSCH, J.L., Positive differential heterophile antibody test. J.A.M.A., 236, 1492–1493 (1976).

    Article  PubMed  CAS  Google Scholar 

  • BANATVALA, J.E., BEST, J.M., and WALLER, D.K., Epstein-Barr virus-specific IgM in infectious mononucleosis, Burkitt lymphoma, and nasopharyngeal carcinoma. Lancet, 1, 1205–1208 (1972).

    Article  PubMed  CAS  Google Scholar 

  • BENDER, C.E., Recurrent mononucleosis. J.A.M.A., 182, 954–956 (1962).

    PubMed  CAS  Google Scholar 

  • BERNSTEIN, A., Infectious mononucleosis. Medicine, 19, 85–159 (1940).

    Article  Google Scholar 

  • CHANG, R.S., EB-virus-seropositive person is susceptible to infectious mononucleosis. N. Engl. J. Med., 292, 925 (1975).

    PubMed  CAS  Google Scholar 

  • CHANG, R.S., and MADDOCK, R., Recurrence of infectious mononucleosis. Lancet, 1, 704 (1980).

    PubMed  CAS  Google Scholar 

  • CONTRATTO, A.W., Infectious mononucleosis. A study of one hundred and ninety-six cases. Arch. Int. Med. 73, 449–459 (1944).

    Google Scholar 

  • DUBOIS, R.E., SEELEY, J.K., BRUS, I., SAKAMOTO, K., BALL0W, M., HARADA, S., BECHT0LD, T.A., PEARSON, G., and PURTILO, D.T., Chronic mononucleosis syndrome. South. Med. J., 77, 1376–1382 (1984).

    Article  PubMed  CAS  Google Scholar 

  • GINSBURG, C.M., HENLE, W., HENLE, G., and HORWITZ, C.A., Infectious Mononucleosis In Children. J.A.M.A. 237, 781–785 (1977).

    Article  PubMed  CAS  Google Scholar 

  • GRAVES, S., JR., Recurrent infectious mononucleosis. J. Kentucky Med. Assoc. December issue, pp. 790–792(1970).

    Google Scholar 

  • Henle, W., And Henle, G., Epstein-Barr virus-specific serology in immunologically compromised individuals. Cancer Res., 41, 4222–4225 (1981).

    PubMed  CAS  Google Scholar 

  • Hoagland, R., Infectious Mononucleosis, Grune and Stratten, Inc., New York (1967).

    Google Scholar 

  • HORWITZ C.A., HENLE, W., HENLE, G., and SCHMITZ, H., Clinical evaluation of patients with infectious mononucleosis and development of antibodies to the R component of the Epstein-Barr virus-induced early antigen complex. Am. J. Med., 58, 330–338 (1975).

    Article  PubMed  CAS  Google Scholar 

  • ISAACS, R., Chronic infectious mononucleosis. Blood, 3, 858–861 (1948).

    PubMed  CAS  Google Scholar 

  • KAUFMAN, R.E., Recurrences in infectious mononucleosis. Amer. Practit. 1, 673–676 (1950).

    CAS  Google Scholar 

  • MORAG, A., TOBI, M., RAVID, Z., SCHATTNER, A., AND PATERSON, J.K., and PINNINGER, J.L., A case of recurrent infectious mononucleosis. Br. Med. J., 2, 476 (1955).

    Article  Google Scholar 

  • PATERSON, J.K., and PINNINGER, J.L., A case of recurrent infectious mononucleosis. Br. Med. J., 2, 476 (1955).

    Article  PubMed  CAS  Google Scholar 

  • PURTILO, D.T., PAQUIN, L.A., SAKAMOTO, K., HUTT, L.M., YANG, J.P.S., Sparling, S., Beberman, N., And Mcauley, R.A., Persistent transfusion-associated infectious mononucleosis with transient acquired immunodeficiency. Am. J. Med., 68, 437–440 (1980).

    Article  PubMed  CAS  Google Scholar 

  • REVEL, M., Elevated [2’-5’]-oligo A synthetase activity in patients with prolonged illness associated with serologic evidence of persistent EBV infection. Lancet, 1, 744–746 (1982).

    PubMed  Google Scholar 

  • STEVENS, D.A., PRY, T.W., And Manaker, R.A., Infectious mononucleosis—Always a primary infection with herpes-type virus ? J. Natl. Cancer Inst., 44, 533–537 (1970).

    PubMed  CAS  Google Scholar 

  • TOBI, M., RAVID, Z., FELDMAN-WEISS, V., BEN-CHETRIT, E., MORAG, A., CHOWERS, I., MICHAELI, Y., SHALIT, M., and KNOBLER, H., Prolonged atypical illness associated with serological evidence of persistent Epstein-Barr virus infection. Lancet, 1, 61–64 (1982).

    Article  PubMed  CAS  Google Scholar 

  • WECHSLER, H.F., ROSENBLUM, A.H., and SILLS, C.T., Infectious mononucleosis: Report of an epidemic in an army post. Part II. Ann. Int. Med., 25, 236–265 (1946).

    Google Scholar 

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P. H. Levine D. V. Ablashi G. R. Pearson S. D. Kottaridis

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© 1985 Martinus Nijhoff Publishing, Boston

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Straus, S.E. (1985). Relapsing, Recurrent, and Chronic Infectious Mononucleosis in the Normal Host. In: Levine, P.H., Ablashi, D.V., Pearson, G.R., Kottaridis, S.D. (eds) Epstein-Barr Virus and Associated Diseases. Developments in Medical Virology, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2625-0_2

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  • DOI: https://doi.org/10.1007/978-1-4613-2625-0_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9641-6

  • Online ISBN: 978-1-4613-2625-0

  • eBook Packages: Springer Book Archive

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