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Brief Communication Fossa of Rosenmuller: The Site for Initial Development of Carcinoma of the Nasopharynx

  • U. Prasad
  • J. Singh
  • R. Patmanathan
Part of the Developments in Medical Virology book series (DIMV, volume 1)

Summary

Along with the fossa of Rossenmuller (FOR), other walls of the nasopharynx have been considered to be the site of origin of the carcinoma of the nasopharynx (NPC), a disease presumed to be caused by the Epstein-Barr virus. In this study, a detailed analysis of clinical, radiological and histopathological findings in 150 confirmed cases of NPC has been made which suggests that all the carcinomas of the nasopharynx originate from cells lining the FOR. A possible interaction between these epithelial cells (columnar or squamous) which are more prone to onslaught by the environmental agent, the subepithelial lymphocytes and the lymphotropic virus EBV could explain the pathogenesis of this cancer.

Keywords

Squamous Cell Carcinoma Nasopharyngeal Carcinoma Environmental Agent Eustachian Tube Early Lesion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Martinus Nijhoff Publishing, Boston 1985

Authors and Affiliations

  • U. Prasad
    • 1
  • J. Singh
    • 2
  • R. Patmanathan
    • 3
  1. 1.Department of E.N.TUniversity of MalayaKuala LumpurMalaysia
  2. 2.Department of RadiologyUniversity of MalayaKuala LumpurMalaysia
  3. 3.Department of PathologyUniversity of MalayaKuala LumpurMalaysia

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