Brief Communication Fossa of Rosenmuller: The Site for Initial Development of Carcinoma of the Nasopharynx

  • U. Prasad
  • J. Singh
  • R. Patmanathan
Part of the Developments in Medical Virology book series (DIMV, volume 1)


Along with the fossa of Rossenmuller (FOR), other walls of the nasopharynx have been considered to be the site of origin of the carcinoma of the nasopharynx (NPC), a disease presumed to be caused by the Epstein-Barr virus. In this study, a detailed analysis of clinical, radiological and histopathological findings in 150 confirmed cases of NPC has been made which suggests that all the carcinomas of the nasopharynx originate from cells lining the FOR. A possible interaction between these epithelial cells (columnar or squamous) which are more prone to onslaught by the environmental agent, the subepithelial lymphocytes and the lymphotropic virus EBV could explain the pathogenesis of this cancer.


Squamous Cell Carcinoma Nasopharyngeal Carcinoma Environmental Agent Eustachian Tube Early Lesion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Cantril, S.T. And Buschke, F., Malignant tumours of the nasopharynx. West. J. Surg., 54, 494–496 (1946).PubMedGoogle Scholar
  2. Davies, E.D.D., Diagnosis and treatment of tumours of nasopharynx. J. Laryng. Otol., 62, 192–205 (1948).Google Scholar
  3. Dawes, J.D.K., Malignant disease of the nasopharynx. J. Laryng. Otol., 83, 21–28 (1969).Google Scholar
  4. Hickley, H.L., Nasopharyngeal malignant tumour. Arch. Otolaryng., 53, 53–67 (1951).Google Scholar
  5. Ho, J.H.C., Stage classification of nasopharyngeal carcinoma: A review. In: G. de The and Y. Ito (ed.) Nasopharyngeal carcinoma: Etiology and control. International Agency for Research in Cancer, Lyon, France, 99–113 (1978).Google Scholar
  6. Oreskovic, M., Petric, K., And Padovan, S., The otoneuro-ophthalmologic diagnosis in tumours of the nasopharynx. J. Laryng. Otol., 82, 575–601 (1968).Google Scholar
  7. Prasad, U., Cancer of the nasopharynx, a clinical analysis with anatomico-pathological orientation. J.R. Coll. Surg., Edinb., 17, 108–117 (1972).Google Scholar
  8. Prasad, U., Cells of origin of nasopharyngeal carcinoma: An electron microscopic study. J. Laryng. Otol. 88, 1087–94 (1974).Google Scholar
  9. Prasad, U., Nasopharyngeal carcinoma, etiological aspects and electron microscopic observations., J.R. Coll. Surg., Edinb., 23, 199–207 (1978).Google Scholar
  10. Prasad, U., Fossa of Rosenmuller and nasopharyngeal carcinoma. Med. J., Malaysia, 33, 222–225 (1979).Google Scholar
  11. Prasad, U., Problem of occult primary nasopharyngeal carcinoma. In: U. Prasad, D.V. Ablashi, P.H. Levine, and G.R. Pearson (ed.) Nasopharyngeal carcinoma- current concepts. Univ. of Malaya, Kuala Lumpur, 11–15 (1983).Google Scholar
  12. PRATHAP, K., PRASAD, U., and ABLASHI, D.V., The pathology of nasopharyngeal carcinoma in Malaysians. In: U. Prasad, D.V. Ablashi, P.H. Levine and G.R. Pearson (ed.). Nasopharyngeal carcinoma- current concepts. Univ. of Malaya, Kuala Lumpur, 55–63 (1983).Google Scholar
  13. SHANMUGARATNAM, K., Studies on the etiology of nasopharyngeal carcinoma. Int. Rev. of Exp. Path., 361–413 (1971).Google Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1985

Authors and Affiliations

  • U. Prasad
    • 1
  • J. Singh
    • 2
  • R. Patmanathan
    • 3
  1. 1.Department of E.N.TUniversity of MalayaKuala LumpurMalaysia
  2. 2.Department of RadiologyUniversity of MalayaKuala LumpurMalaysia
  3. 3.Department of PathologyUniversity of MalayaKuala LumpurMalaysia

Personalised recommendations