Summary
Sera from 129 Malaysian patients with NPC and controls were assayed for antibodies to EBV-related antigens. Histopathologically there were 30 WHO type 1, 20 WHO type 2 and 79 WHO type 3 tumour cases. There was no significant difference between the geometric mean titre (GMT) of the anti-EBV antibodies for the three WHO type tumours. In the Chinese, Malays and Kadazan patients the titres of IgG anti-EA and IgA anti-VCA antibodies increased with the stage of the disease; in the Chinese NPC patients the GMT titres decreased at Stage IV but in the Malay and Kadazan NPC patients the titres continued to increase. Morever, the GMT for anti-EBV antibodies were higher in the younger NPC patients (<39) compared to older patients at all stages of the disease. It appears that the IgA anti-VCA antibody response is specific to NPC and is a useful diagnostic aid when used alone or when used in combination with IgG anti-EA titres.
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© 1985 Martinus Nijhoff Publishing, Boston
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Yadav, M., Malliha, N., Norhanom, A.W., Prasad, U. (1985). Use of Epstein-Barr Virus Serology in the Diagnosis of Nasopharyngeal Carcinoma in Malaysia. In: Levine, P.H., Ablashi, D.V., Pearson, G.R., Kottaridis, S.D. (eds) Epstein-Barr Virus and Associated Diseases. Developments in Medical Virology, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2625-0_15
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DOI: https://doi.org/10.1007/978-1-4613-2625-0_15
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