Nasopharyngeal Carcinoma : Early Detection and IGA-Related Pre-NPC Condition.Achievements and Prospectives

  • Yi Zeng
  • Guy de The
Part of the Developments in Medical Virology book series (DIMV, volume 1)


Undifferentiated carcinomas of the nasopharynx (or NPC) represent a major cancer killer for more than 200 million people in South China, as well as in large areas of the South East Asia, North and East Africa and in Eskimo populations. This cancer is closely associated with the ubiquitous Epstein Barr herpes virus. In contrast with the situation observed in Burkitt’s Lymphoma, the association between EBV and NPC is constant in every part of the world where NPC is observed, and unrelated to its level of incidence. Such an association, most probably causative in nature, has recently been reviewed (de-Thé, 1982,1984).


Nasopharyngeal Carcinoma Raji Cell Undifferentiated Carcinoma Eskimo Population Nasopharyngeal Mucosa 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Desgranges, C., and de Thé, G., IgA and nasopharyngeal carcinoma, in: Oncogenesis and Herpesviruses III (G. de Thé, Y. Ito, and F. Rapp, eds.), pp.883–891, IARC Scientific Publications N° 25, Lyon, (1978).Google Scholar
  2. Desgranges, C., Bornkamm, G.W., Zeng, Y., Wang, P.C., Zhu, J.S., Shang, H., and de Thé, G., Detection of Epstein-Barr viral DNA in the nasopharyngeal mucosa of Chinese with IgA/EBV-specific antibodies, Int. J. Cancer 29: 187–191 (1982)CrossRefGoogle Scholar
  3. Desgranges, C., Pi, G.H., Bornkaram, G.H., Legrand, C., Zeng, Y and de The, G., Presence of EBV-DNA sequences in naso¬pharyngeal cells of individuals without IgA/VCA antibodies. Int. J. Cancer, 32: 543–545, (1983).PubMedCrossRefGoogle Scholar
  4. De Thé, G., Epidemiology of Epstein-Barr Virus and Associated Diseases in Man, in: The Herpesviruses, vol. 1, Roizman, B. (ed.), pp 25–103, Plenum Publishing Corporation, New York (1982).Google Scholar
  5. De Thé, G., The role of the Epstein-Barr Virus (EBV) in the etiology and control of nasopharyngeal carcinoma (NPC). In: Cancer of the Head and Neck, Williams and Wilkins Publishers, (1984).Google Scholar
  6. De Thé, G., Zeng, Y., Desgranges, C., and Pi, G.H. The Existence of Pre-Nasopharyngeal Carcinoma Conditions Should Allow Preventive Interventions, In: Nasopharyngeal Carcinoma: Current Concepts, Prasad etal,(eds.), University of Malaya, Kuala Lumpur, pp. 365–374, (1983).Google Scholar
  7. Ito, Y., Ohigashi, H., Koshimizu, K., Zeng, Y., Epstein- Barr Virus-activating principle in the ether extracts of soils collected from under plants which contain active diterpene esters. Cancer Letters, 19,pp. 113–117, Elsevier Scientific Publishers Ireland Ltd, (1983).Google Scholar
  8. Henle, G., and Henle, W., Epstein-Barr virus-specific IgA serum antibodies as an outstanding feature of nasopharyngeal carcinoma, Int. J. Cancer 17: 1–7, (1976)PubMedCrossRefGoogle Scholar
  9. Laboratory of Tumor Viruses of Cancer Institute, Laboratory of Tumor Viruses of Institute of Epidemiology, Department of Radiotherapy of Cancer Institute, Department of Otolaryngology of Beijing Worker-Peasant-Soldier Hospital, Detection of EB virus-specific serum IgG and IgA antibodies from patients with nasopharyngeal carcinoma, (1978). Acta Microbiol, Sin. 18, 253–258Google Scholar
  10. Pi, G.H., Zeng, Y., de Thé, G., Enzyme-linked immunosorbent Assay for the detection of Epstein-Barr Virus IgA/EA antibody (submitted for publication).Google Scholar
  11. Shen, S.J., Chen, C.P., Ma, J.L., Zhong, W., Zeng, Y.. Further study on detection of EBNA from nasopharyngeal exfoliated cells of patients with nasopharyngeal carcinoma. Acta Zhanjiang Medical College, 1, 34–37 (1983)Google Scholar
  12. Tao, E.C., Wang, P.C., Wei, J.N., Li, E.J., Wei, R.F., Too, C.M., Gu, S.T., Tan, S.M., Tang, H., Zeng, Y., Pi, G.H. Serological Mass Survey of Nasopharyngeal Carcinoma in Laucheng County, (submitted for publication).Google Scholar
  13. Wara, W.M., Wara, D.W., Phillips, T.L., and Ammahh, A. Elevated IgA in Carcinoma of the Nasopharynx, Cancer 35: 1313–1315 (1975)PubMedCrossRefGoogle Scholar
  14. Zeng, Y., Liu, Y.X., Wei, J.N., Zhu, J.S., Cai, S.L., Wang, P.Z., Zhong, J.M., Li, R.C., Pan, W.J., Li, E.J., and Tan, B.F. Serological mass survey of nasopharyngeal carcinoma. Acta Acad. Med. Sin. 1, 123–126, (1979)Google Scholar
  15. Zeng, Y., Liu, Y.X., Liu, Z.R., Zhen, S.W., Wei, J.N., Zhu, J.S. and Zei, H.S. Application of an immunoenzymatic method and an immunoautoradiographic method for a mass survey of nasopharyngeal carcinoma, Intervirology, 13, 162–168, (1980)CrossRefGoogle Scholar
  16. Zeng, Y., Zhang, L.G., Li, H.Y., Jan, M.C., Zhang, Q., Wu, Y.C., Wang, Y.S., and Su, G.R. Serological mass survey for early detection of nasopharyngeal carcinoma in Wuzhou City, China. Int. J. Cancer 29, 139–141, (1982)PubMedCrossRefGoogle Scholar
  17. Zeng, Y., Zhong, J.M., Li, L.Y., Wang, P.Z., Tang, H., Ma, Y.R., Zhu, T.S., Pan, W.J., Liu, Y.X., Wei, J.N., Chen, J.Y., M.Y.K., Li, E.J., Tan, B.F. Follow-up studies on Epstein- Barr, virus IgA/VCA Antibody Positive Persons in Zangwu County, China. Intervirology. 20, 190–194, (1983)PubMedCrossRefGoogle Scholar
  18. Zeng, Y., Gi, Z.W., Wang, P.C., Tan, H.Z., Ito, Y., Induction of Epstein-Barr Virus Antigen in Raji cells and P3HR-1 cells by culture fluids of anaerobes from nasopharynx of patients with nasopharyngeal carcinoma and with other ear-nose-throat diseases, (submitted for publication)Google Scholar
  19. Zerig, Y., Miao, X.C., Jaio, B., Li, H.Y,, Ni, H.Y., and Ito, Y., Epstein-Barr Virus activation in Raji cells with ether extracts of soil from different areas in China. Cancer Letters, in press.Google Scholar
  20. Zeng, Y., Gong, M«G., Jan, M.G., Fun, Zeng, L.G. and Li, H.Y, Detection of Epstein-Barr Virus IgA/EA antibody for diagnosis of nasopharyngeal carcinoma by immunoautoradiography. Int. J. Cancer, 31, 599–601, (1983)PubMedCrossRefGoogle Scholar
  21. Zeng, Y., Zhong, J.M., Mo, Y.K., Miao, X.C., Epstein-Barr virus early antigen induction in Raji cells by Chinese medical herbs. Intervirology, 19, 201–204, (1983)PubMedCrossRefGoogle Scholar
  22. Zhangjiang Medical College, Diagnosis of nasopharyngeal carcinoma by cytological examination of exfoliated cells taken by negative pressure suction. Chin. med. J., 1, 45–47 (1976)Google Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1985

Authors and Affiliations

  • Yi Zeng
    • 1
  • Guy de The
    • 1
  1. 1.Institute of Virology-Beijing- PRC and CNRS LaboratoryFac. of Med. A. CarrelLyonFrance

Personalised recommendations