Association of Epstein-Barr Virus and Lymphoproliferative Diseases in Immune Deficient Persons

  • David T. Purtilo
Part of the Developments in Medical Virology book series (DIMV, volume 1)


Multiple immune responses ordinarily provide tight security against life-threatening Epstein-Barr virus (EBV)-induced diseases. However, studies performed predominantly during the recent decade have demonstrated that individuals with acquired or inherited immune deficiency disorders are subject to life-threatening diseases related to EBV, The diseases seem to result depending on the type and degree of the immune deficiency and when the immune deficiency occurs with respect to primary infection by the virus. The X-linked lymphoproliferative syndrome (XLP) serves as a model demonstrating that immune deficient individuals can develop a spectrum of diseases including acquired agammaglobulinemia, aplastic anemia, red cell aplasia, or proliferative disorders such as chronic or fatal infectious mononucleosis, pseudolymphoma or malignant B cell lymphoma. Similarly, renal transplant recipients can develop a fatal infectious mononucleosis-like disease in young seronegative patients, whereas older individuals tend to show reactivation of virus and develop malignant lymphomas. Patients with AIDS have also developed EBV-carrying malignant lymphomas.


Renal Transplant Recipient Immune Deficiency Acquire Immune Deficiency Syndrome Hairy Cell Leukemia Lymphoproliferative Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Martinus Nijhoff Publishing, Boston 1985

Authors and Affiliations

  • David T. Purtilo
    • 1
  1. 1.Department of Pathology and Laboratory Medicine, Pediatrics, and Eppley InstituteUniversity of Nebraska Medical CenterOmahaUSA

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