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Ewings’ Sarcoma

  • Chapter
Book cover Diagnosis and Management of Malignant Solid Tumors in Infants and Children

Part of the book series: Developments in Oncology ((DION,volume 37))

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Abstract

Ewing’s sarcoma is the second most common primary bone tumor in pediatric patients. The incidence rate was 2.1 cases per million U.S. white children less than 15 years of age per year. The corresponding figure for U.S. black children was 0.0 264. The highest incidence rate was 3.9, among boys in Queensland, Australia. The lowest rates were among U.S. black boys and girls, both having an incidence rate of 0.0 16,17,55,67,159,160,180,238,263,265 (Table 1). The rarity of Ewing’s sarcoma in black populations has been confirmed by several investigators 22,44,116,167,258. Ewing’s sarcoma is also rare among the Chinese 142.

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References

  1. Abrams RA, Simon R, Glaubiger D, Lichter A and Deisseroth AB: Haematopoietic recovery in Ewing’s sarcoma after intensive combination therapy and autologous marrow infusion. Lancet 2: 385–389, 1980.

    PubMed  CAS  Google Scholar 

  2. Anderson FM and Carson MJ: Spinal cord tumors in children. J Pediatr 43: 190–207, 1953.

    PubMed  CAS  Google Scholar 

  3. Angervall L and Enzinger FM: Extraskeletal neoplasm resembling Ewing’s sarcoma. Cancer 36: 240–251, 1975.

    PubMed  CAS  Google Scholar 

  4. Aurias A, Rimbaut C, Buffe D, Zucker J-M and Mazabruad A: Translocation involving chromosme 22 in Ewing’s sarcoma. Cancer Genet Cytogenet 12: 21–25, 1984.

    PubMed  CAS  Google Scholar 

  5. Ayala AG and Zornosa J: Primary bone tumors: Percutaneous needle biopsy. Radiology 149: 675–679, 1983.

    PubMed  CAS  Google Scholar 

  6. Bacci G, Campanacci M and Pagani PA: Adjuvant chemotherapy in the treatment of clinically localised Ewing’s sarcoma. J Bone Joint Surg 60-B: 567–574, 1978.

    Google Scholar 

  7. Bacci G, Picci P, Gitelis S, Borghi A and Campanacci M: The treatment of localized Ewing’s sarcoma. Cancer 49: 1561–1570, 1982.

    PubMed  CAS  Google Scholar 

  8. Baird RJ and Krause VW: Ewing’s tumour: A review of 33 cases. Can J Surg 6: 136–140, 1963.

    PubMed  CAS  Google Scholar 

  9. Bauer FCH, Mirra JM and Urist MR: Bone induction by Ewing’s sarcoma. Arch Pathol Lab Med 105: 322–324, 1981.

    PubMed  CAS  Google Scholar 

  10. Baum EW, Gaynon P, Greenberg KL, Krivit W and Hammond D: Phase II trial of cisplatin in refractory childhood cancer: Children’s cancer study group. Cancer Treat Rep 65: 815–822, 1981.

    PubMed  CAS  Google Scholar 

  11. Becher R, Wake N, Gibas Z, Ochi H and Sandberg AA: Chromosome changes in soft tissue sarcomas. J Nat Cancer Inst 72: 823–831, 1984.

    PubMed  CAS  Google Scholar 

  12. Becroft DMO, Pearson A, Shaw RL and Zwi LJ: Chromosome translocation in extraskeletal Ewing’s tumour. Lancet 2:400, 1984 (Letter).

    PubMed  CAS  Google Scholar 

  13. Bergstrand H: Four cases of Ewing sarcoma in ribs. Am J Cancer 27: 26–36, 1936.

    Google Scholar 

  14. Berthold F, Kracht J, Lampert F, Millar TJ, Muller TH, Reither M and Unsicker K: Ultrastructural, biochemical and cell-culture studies of presumed extraskeletal Ewing’s sarcoma with special reference to differential diagnosis from neuroblastoma. Cancer Res Clin Oncol 103: 293–304, 1982.

    CAS  Google Scholar 

  15. Bhansali SK and Desai PB: Ewing’s sarcoma. J Bone Joint Surg 45-A: 541–558, 1963.

    Google Scholar 

  16. Birch JM: Personal communication.

    Google Scholar 

  17. Birch JM, Marsden HB and Swindell R: Incidence of malignant disease in childhood: A 24-year review of the Manchester children’s tumour registry data. Br J Cancer 42: 215–223, 1980.

    PubMed  CAS  Google Scholar 

  18. Bleyer WA, Krivit W, Chard RL Jr and Hammond D: Phase II study of VM-26 in acute leukemia, neuroblastoma and other refractory childhood malignancies: A report from the children’s cancer study group. Cancer Treat Rep 63: 977–981, 1979.

    PubMed  CAS  Google Scholar 

  19. Bonnadonna G, Beretta G, Tancini G, Brambilla C, Bajetta E, De Palo GM, De Lena M, Fossati-Bellani F, Gasparini M, Valagussa P and Veronesi U: Adriamycin (NSC-123127) studies at the Instituto Nazionale Tumori, Milan. Cancer Chemo Rep, Part 3, 6: 231–245, 1975.

    Google Scholar 

  20. Boyer CW, Brickner TJ Jr and Perry RH: Ewing’s sarcoma. Cancer 20: 1602–1606, 1967.

    PubMed  Google Scholar 

  21. Branson J: Ewing’s tumour of rib. Aust Radiol 20: 341–345, 1976.

    CAS  Google Scholar 

  22. Bras G, Cole H, Ashmeade-Dyer A and Watler DC: Report on 151 childhood malignancies observed in Jamaica. J Nat Cancer Inst 43: 417–421, 1969.

    PubMed  CAS  Google Scholar 

  23. Brav EA and Rechtman AM: Primary endotheliomyeloma (Ewing’s tumor) of the sacrum. J Bone Joint Surg 20: 1034–1038, 1938.

    Google Scholar 

  24. Brereton HD, Simon R and Pomeroy TC: Pretreatment serum lactate dehydrogenase predicting metastatic spread in Ewing’s sarcoma. Ann Int Med 83: 352–354, 1975.

    PubMed  CAS  Google Scholar 

  25. Brown ML: Significance of the solitary lesion in pediatric bone scanning: Concise communication. J Nucl Med 24: 114–115, 1983.

    PubMed  CAS  Google Scholar 

  26. Campbell WC: Endothelial myeloma. J Bone Joint Surg 16: 761–780, 1934.

    Google Scholar 

  27. Campbell WC and Hamilton JF: Ewing’s tumor (endothelial myeloma). J Bone Joint Surg 20: 1019–1027, 1938.

    Google Scholar 

  28. Carl W, Schaaf NG, Gaeta J and Sinks LF: Ewing’s sarcoma. Oral Surg 31: 472–478, 1971.

    PubMed  CAS  Google Scholar 

  29. Chabora BM, Rosen G, Cham W, D’Angio GJ and Tefft M: Radiotherapy of Ewing’s sarcoma. Radiology 120: 667–671, 1976.

    PubMed  CAS  Google Scholar 

  30. Chan KW, Rosen G and Pollack MS: Distribution of HLA antigens in patients with Ewing’s sarcoma. Tis Antigens 16: 314–316, 1980.

    CAS  Google Scholar 

  31. Chan RC, Sutow WW, Lindberg RD, Samuels ML, Murray JA and Johnston DA: Management and results of localized Ewing’s sarcoma. Cancer 43: 1001–1006, 1979.

    PubMed  CAS  Google Scholar 

  32. Chard RL Jr, Krivit W, Bleyer WA and Hammond D: Phase II study of VP-16–213 in childhood malignant disease: A children’s cancer study group report. Cancer Treat Rep 63: 1755–1759, 1979.

    PubMed  Google Scholar 

  33. Cohen M, Grosfeld J, Baehner R and Weetman R: Lung CT for detection of metastases: Solid tissue neoplasms in children. Am J Roentgenol 139: 895–898, 1982.

    CAS  Google Scholar 

  34. Cohen M, Provisor A, Smith WL and Weetman R: Efficacy of whole lung tomography in diagnosing metastases from solid tumors in children. Radiology 141: 375–378, 1981.

    PubMed  CAS  Google Scholar 

  35. Cohen M, Smith WL, Weetman R and Provisor A: Pulmonary pseudometastases in children with malignant tumors. Radiology 141: 371–374, 1981.

    PubMed  CAS  Google Scholar 

  36. Coley BL: Neoplasms of Bone. Second Edition. Paul B Hoeber Inc, New York, 1960, p 353.

    Google Scholar 

  37. Colville HC and Willis RA: Neuroblastoma metastases in bones, with a criticism of Ewing’s endothelioma. Am J Pathol 9: 421–429, 1935.

    Google Scholar 

  38. Connor CL: A further consideration of Ewing’s sarcoma. Am J Cancer 22: 4151, 1934.

    Google Scholar 

  39. Connor CL: Endothelial myeloma. Ewing. Report of fifty-four cases. Arch Surg 12: 789–829 1926.

    Google Scholar 

  40. Connor CL: Experimental sarcoma of bone. Arch Surg 19: 794–807, 1929.

    Google Scholar 

  41. Cornbleet MA, Corringham RET, Prentice HG, Boesen EM and McElwain TJ: Treatment of Ewing’s sarcoma with high-dose melphalan and autologous bone marrow transplantation. Cancer Treat Rep 65: 241–244, 1981.

    PubMed  CAS  Google Scholar 

  42. Culbert S, Cangir A, Jaffe N, Sullivan MP and Dicke K: Therapeutic potential of high dose phenylalanine mustard (HDP) in pediatric solid tumors. Proc Am Assoc Cancer Res 22: 400, 1981 (Abstract).

    Google Scholar 

  43. Dahlin DC: Bone Tumors. Third Edition. Charles C Thomas, Springfield, 1978, pp 274–287.

    Google Scholar 

  44. Davies JNP: Childhood tumours. IN Tumours in a Tropical Country. AC Templeton (ed), Springer-Verlag, New York, 1973, pp 306–320.

    Google Scholar 

  45. Delta BG and Pinkel D: Bone marrow aspiration in children with malignant tumors. J Pediatr 64: 542–546, 1964.

    PubMed  CAS  Google Scholar 

  46. de Santos LA, Murray JA and Ayala AG: The value of percutaneous needle biopsy in the management of primary bone tumors. Cancer 43: 735–744, 1979.

    Google Scholar 

  47. Dickman PS, Liotta LA and Triche TJ: Ewing’s sarcoma. Lab Invest 47: 375–382, 1982.

    PubMed  CAS  Google Scholar 

  48. Douer D, Champlin RE, Ho WG, Sarna GP, Wells JH, Graze PR, Cline MJ and Gale RP: High-dose combined modality therapy and autologous bone marrow transplantation in resistant cancer. Am J Med 71: 973–976, 1981.

    PubMed  CAS  Google Scholar 

  49. Douglass E, Green A, Hayes A, Brodeur G and Thompson E: Deletions of chromosomes 1 and 3 in Ewing’s sarcoma. Proc Am Assoc Cancer Res 24: 11, 1983 (Abstract).

    Google Scholar 

  50. Dvorak PF, Vorlicky LN and Nesbit ME Jr: Ewing’s sarcoma of the rib, presenting as the superior mediastinal syndrome. Clin Pediatr 10: 607–610, 1971.

    CAS  Google Scholar 

  51. Dwyer J, Glaubiger DL, Ecker JG, Doppman JL, Prewitt JM and Plunkett M: The radiographic follow-up of patients with Ewing’s sarcoma: A demonstration of a general method. Radiology 145: 327–331, 1982.

    PubMed  CAS  Google Scholar 

  52. Edland RW: Ewing’s sarcoma of the spine. Radiol Clin Biol 37: 162–168, 1968.

    PubMed  CAS  Google Scholar 

  53. Enneking WF and Dunham WK: Resection and reconstruction for primary neoplasms involving the innominate bone. J Bone Joint Surg 60-A: 731–746, 1978.

    Google Scholar 

  54. Enneking WF and Kagan A II: Transepiphyseal extension of osteosarcoma: Incidence, mechanism and implications. Cancer 41: 1526–1537, 1978.

    PubMed  CAS  Google Scholar 

  55. Ericsson J L-E, Karnstrom L and Mattsson B: Childhood cancer in Sweden. 19581974. Acta Paediatr Scand 67: 425–432, 1978.

    PubMed  CAS  Google Scholar 

  56. Evans AE: Mitomycin C. Cancer Chemo Rep 14: 1–9, 1961.

    CAS  Google Scholar 

  57. Evans AE, Baehner RL, Chard RL Jr, Leikin SK, Pang EM and Pierce M: Comparison of daunorubicin (NSC-83142), with adriamycin (NSC-123127) in the treatment of late-stage childhood solid tumors. Cancer Chemo Rep 58: 671–676, 1974.

    CAS  Google Scholar 

  58. Ewing J: A review of the classification of bone tumors. Surg Gynecol Obstet 68: 971–976, 1939.

    Google Scholar 

  59. Ewing J: Diffuse endothelioma of bone. Proc New York Pathol Soc 21: 17–24, 1921.

    Google Scholar 

  60. Ewing J: Further report on endothelial myeloma of bone. Proc New York Pathol Soc 24: 93–101, 1924.

    Google Scholar 

  61. Ewing J: Neoplastic Diseases. A Treatise on Tumors. WB Saunders Company, Philadelphia, 1940, pp 362–370.

    Google Scholar 

  62. Falk S and Alpert M: The clinical and roentgen aspects of Ewing’s sarcoma. Am J Med Sci 250: 492–508, 1965.

    PubMed  CAS  Google Scholar 

  63. Fernandez CH, Lindberg RD, Sutow WW and Samuels ML: Localized Ewing’s sarcoma–treatment and results. Cancer 34: 143–148, 1974.

    PubMed  CAS  Google Scholar 

  64. Finklestein JZ, Albo, V, Ertel I and Hammond D: 5-(3,3-dimethyl-l- triazeno)imidazole-4-carboxamide (NSC-45388) in the treatment of solid tumors in children. Cancer Chemo Rep 59: 351–357, 1975.

    CAS  Google Scholar 

  65. Finklestein JZ, Ekert H, Isaacs H Jr and Higgins G: Bone marrow metastases in children with solid tumors. Am J Dis Child 119: 49–52, 1970.

    PubMed  CAS  Google Scholar 

  66. Finklestein JZ, Hittle RE and Hammond D: Evaluation of a high dose cyclophosphamide regimen in childhood tumors. Cancer 23: 1239–1242, 1969.

    PubMed  CAS  Google Scholar 

  67. Finnish Cancer Registry: Cancer in Finland 1980. Cancer Society of Finland Publication No 32, Finnish Cancer Registry. Helsinki, 1983, p 29.

    Google Scholar 

  68. Foote FW Jr and Anderson HR: Histogenesis of Ewing’s tumor. Am J Pathol 17: 497–502, 1941.

    PubMed  CAS  Google Scholar 

  69. Fraumeni JF Jr: Stature and malignant tumors of bone in childhood and adolescence. Cancer 20: 967–973, 1967.

    PubMed  Google Scholar 

  70. Freeman AI, Sachatello C, Gaeta J, Shah NK, Wang JJ and Sinks LF: An analysis of Ewing’s tumor in children at Roswell Park Memorial Institute. Cancer 29: 1563–1569, 1972.

    PubMed  CAS  Google Scholar 

  71. Friedman B and Gold H: Ultrastructure of Ewing’s sarcoma of bone. Cancer 22: 307–322, 1968.

    PubMed  CAS  Google Scholar 

  72. Gasparini M and Lombardi F: Adjuvant chemotherapy in Ewing’s sarcoma patients. IN. Adjuvant Therapies of Cancer. G Mathe, G Bonadonna and S Salmon (ed), Springer-Verlag, New York, 1982, pp 120–123.

    Google Scholar 

  73. Gasparini M, Lombardi F, Gianni C and Fossati-Bellani F: Localized Ewing’s sarcoma: Results of integrated therapy and analysis of failures. Eur J Cancer 17: 1205–1209, 1981.

    CAS  Google Scholar 

  74. Gehan EA, Nesbit ME Jr, Burgert EO Jr, Vietti TJ, Tefft M, Perez CA, Kissane J and Hempel C: Prognostic factors in children with Ewing’s sarcoma. Nat Cancer Inst Mono 56: 273–278, 1981.

    Google Scholar 

  75. Geschickter CF and Copeland MM: Tumors of Bone. Third Edition. JB Lippincott Company, Philadelphia, 1949, pp 387–434.

    Google Scholar 

  76. Ghandur-Mnaymneh L, Mnaymneh WA and Puls S: The incidence and mechanism of transphyseal spread of osteosarcoma of long bones. Clin Ortho 177: 210–215, 1983.

    Google Scholar 

  77. Gilday DL, Ash JM and Reilly BJ: Radionuclide skeletal survey for pediatric neoplasms. Radiology 123: 399–406, 1977.

    PubMed  CAS  Google Scholar 

  78. Glass AG and Fraumeni JF Jr: Epidemiology of bone cancer in children. J Nat Cancer Inst 44: 187–199, 1970.

    PubMed  CAS  Google Scholar 

  79. Glaubiger DL, Makuch R, Schwarz J, Levine AS and Johnson RE: Determination of prognostic factors and their influence on therapeutic results in patients with Ewing’s sarcoma. Cancer 45: 2213–2219, 1980.

    PubMed  CAS  Google Scholar 

  80. Glaubiger DL, Tepper J and Makuch R: Ewing’s sarcoma. IN. Cancer in the Young. AS Levine (ed), Masson Publishing USA, Inc, New York, 1982, pp 603–614.

    Google Scholar 

  81. Goepfert H, Rochlin DB and Smart CR: Palliative treatment of Ewing’s sarcoma. Am J Surg 113:246–250, 1967

    Google Scholar 

  82. Goldman A: Ewing’s sarcoma: Treatment with high-dose radiation and adjuvant chemotherapy. IN. Adjuvant Therapies of Cancer. G Mathe, G Bonadonna and J Salmon (eds), Springer-Verlag, New York, 1982, pp 115–119.

    Google Scholar 

  83. Goldman A and Malpas JS: Phase I and II study of AMSA in childhood tumours. Cancer Chemo Pharmacol 9: 53–56, 1982.

    CAS  Google Scholar 

  84. Goldstein H, McNeil BJ, Zufall E and Treves S: Is there still a place for bone scanning in Ewing’s sarcoma? J Nuc Med 21: 10–12, 1980.

    CAS  Google Scholar 

  85. Graham-Pole J: Ewing’s sarcoma: Treatment with high dose radiation and adjuvant chemotherapy. Med Pediatr Oncol 7: 1–8, 1979.

    PubMed  CAS  Google Scholar 

  86. Graham-Pole J, Lazarus HM, Herzig RH, Gross S, Coecia P, Weiner R and Strandjord S: High-dose melphalan therapy for the treatment of children with refractory neuroblastoma and Ewing’s sarcoma. Am J Pediatr Hematol/Oncol 6: 17–26, 1984.

    CAS  Google Scholar 

  87. Green DM: Unpublished data.

    Google Scholar 

  88. Green DM, Marinello MJ, Fisher J, Mindell ER, Zak TA, Allen JE, Khan AR and Brecher ML: Ewing’s sarcoma of the scapula with metastases to the lung and eye. Am J Pediatr Hematol/Oncol (in press).

    Google Scholar 

  89. Grier H, Green D, Cassady J, Delorey M, Goorin A, Belli J, Jaffe N, Gelber R, Price K and Weinstein H: 10-years of vincristine (V), actinomyein D (A) and cyclophosphamide (C) chemotherapy by intermittent (I) or bolus (B) route for Ewing’s sarcoma. Proc Am Soc Clin Oncol 2: 74, 1983 (Abstract).

    Google Scholar 

  90. Haggard ME, Cangir A, Ragab AH, Komp D, Falletta J and Humphrey GB: 5fluorouracil in childhood solid tumors. Cancer Treat Rep 61: 69–71, 1977.

    CAS  Google Scholar 

  91. Hajdu SI and Melamed MR: Needle biopsy of primary malignant bone tumors. Surg Gynecol Obstet 133: 829–832, 1971.

    PubMed  CAS  Google Scholar 

  92. Hamilton JF: Ewing’s sarcoma (Endothelial myeloma). Arch Surg 41: 29–52, 1940.

    Google Scholar 

  93. Harrington SW: Surgical treatment of intrathoracic tumors and tumors of the chest wall. Arch Surg 14: 406–431, 1927.

    Google Scholar 

  94. Harvey W, Squier MV, Duance VC and Pritchard J: A biochemical and immunohistological study of collagen synthesis in Ewing’s tumour. Br J Cancer 46: 848–855, 1982.

    PubMed  CAS  Google Scholar 

  95. Hayes FA, Thompson EI, Hustu HO, Kumar M, Coburn T and Webber B: The response of Ewing’s sarcoma to sequential cyclophosphamide and adriamycin induction therapy. J Clin Oncol 1: 45–51, 1983.

    PubMed  CAS  Google Scholar 

  96. Hazra DK, Pursnani ML, Agrawal BM, Rohtagi VK, Sharma RD, Mahajan AK, Jain RD and Sharma SK: Ewing’s sarcoma of rib presenting as paraplegia of acute onset. J Assoc Phys Ind 27: 1045–1047, 1979.

    CAS  Google Scholar 

  97. Hedblom CA: Tumors of the bony chest wall. Ann Surg 98: 528–545, 1933.

    PubMed  CAS  Google Scholar 

  98. Herbert WP: Ewing’s tumor of the rib. J Thor Surg 5: 189–194, 1935.

    Google Scholar 

  99. Hinterberger H: Excretion of catecholamines, their precursors and metabolites in patients with neuroblastoma and Ewing’s tumour. Pathology 10: 393, 1978 (Abstract).

    Google Scholar 

  100. Hou-Jensen K, Priori E and Dmochowski L: Studies on ultrastructure of Ewing’s sarcoma of bone. Cancer 29: 280–286, 1972.

    PubMed  CAS  Google Scholar 

  101. Howard WT and Crile GW: A contribution to the knowledge of endothelioma and perithelioma of bone. Ann Surg 42: 358–393, 1905.

    PubMed  CAS  Google Scholar 

  102. Humphrey EW, Hymes AC, Ausman RK and Ferguson DJ: An evaluation of actinomycin D and mitomycin C in patients with advanced cancer. Surgery 50: 881–885, 1961.

    PubMed  CAS  Google Scholar 

  103. Huntington RW, Henkelmann CR and Franklin R: A typical Ewing tumor in the sister of a patient with Ewing’s tumor. J Bone Joint Surg 43-A: 572–574, 1961.

    Google Scholar 

  104. Huntington RW, Sheffel DJ, Iger M and Henkelmann C: Malignant bone tumors in siblings. J Bone Joint Surg 42-A: 1065–1075, 1960.

    Google Scholar 

  105. Husto HO, Holton C, James D Jr and Pinkel D: Treatment of Ewing’s sarcoma with concurrent radiotherapy and chemotherapy. J Pediatr 73: 249–251, 1968.

    Google Scholar 

  106. Hustu HO, Pinkel D and Pratt CB: Treatment of clinically localized Ewing’s sarcoma with radiotherapy and combination chemotherapy. Cancer 30: 1522–1527, 1972.

    PubMed  CAS  Google Scholar 

  107. Hutter RVP, Francis KC and Foote FW Jr: Ewing’s sarcoma in siblings. Am J Surg 107: 598–603, 1964.

    PubMed  CAS  Google Scholar 

  108. Iriarte PV, Hananian J and Cortner JA: Central nervous system leukemia and solid tumors of childhood. Cancer 19: 1187–1194, 1966.

    PubMed  CAS  Google Scholar 

  109. Jaffe N, Traggis D, Sallan S and Cassady JR: Improved outlook for Ewing’s sarcoma with combination chemotherapy (vincristine, actinomycin D and cyclophosphamide) and radiation therapy. Cancer 38: 1925–1930, 1976.

    PubMed  CAS  Google Scholar 

  110. James DH and George P: Vincristine in children with malignant solid tumors. J Pediatr 64: 534–541, 1964.

    PubMed  Google Scholar 

  111. Jenkin D, Berry M and Sonley M: Ewing’s sarcoma (ES). Treatment results with local irradiation (RT), 8 one day cycles of adriamycin, vincristine and cyclophosphamide (DOC) and consolidation with sequential half body irradiation. Proc Am Soc Clin Oncol 3: 81, 1984 (Abstract).

    Google Scholar 

  112. Jenkin RDT: Ewing’s sarcoma. Clin Radiol 17: 97–106, 1966.

    PubMed  CAS  Google Scholar 

  113. Jenkin RDT: Radiation treatment of Ewing’s sarcoma and osteogenic sarcoma. Can J Surg 20: 530–536, 1977.

    PubMed  CAS  Google Scholar 

  114. Jenkin RDT, Rider WD and Sonley MJ: Ewing’s sarcoma. A trial of adjuvant total-body irradiation. Radiology 96: 151–155, 1970.

    PubMed  CAS  Google Scholar 

  115. Jenkin RDT, Rider WD and Sonley MJ: Ewing’s sarcoma. Adjuvant total body irradiation, cyclophosphamide and vincristine. Int J Rad Oncol Biol Phys 1: 407–413, 1976.

    CAS  Google Scholar 

  116. Jensen RD and Drake RM: Rarity of Ewing’s tumour in negroes. Lancet 1:777, 1970 (Letter).

    PubMed  CAS  Google Scholar 

  117. Jentzsch K, Binder H, Cramer H, Glaubiger DL, Kessler RM, Bull C, Pomeroy TC and Gerber NL: Leg function after radiotherapy for Ewing’s sarcoma. Cancer 47: 1267–1278, 1981.

    PubMed  CAS  Google Scholar 

  118. Johnson R and Humphreys SR: Past failures and future possibilities in Ewing’s sarcoma. Cancer 23: 161–166, 1969.

    PubMed  CAS  Google Scholar 

  119. Johnson RE and Pomeroy TC: Evaluation of therapeutic results in Ewing’s sarcoma. Am J Roentgenol 123: 583–587, 1975.

    CAS  Google Scholar 

  120. Johnson RE, Senyszyn JJ, Rabson AS and Peterson KA: Treatment of Ewing’s sarcoma with local irradiation and systemic chemotherapy. Radiology 95: 195–197, 1970.

    PubMed  CAS  Google Scholar 

  121. Joseph WL and Fonkalsrud EW: Primary rib tumors in children. Am Surg 38: 338–342, 1972.

    PubMed  CAS  Google Scholar 

  122. Joyce MJ, Harmon DC, Mankin HJ, Suit HD, Schiller AL and Truman JT: Ewing’s sarcoma in female siblings. Cancer 53: 1959–1962, 1984.

    PubMed  CAS  Google Scholar 

  123. Kadin ME and Bensch KG: On the origin of Ewing’s tumor. Cancer 27: 257–273, 1971.

    PubMed  CAS  Google Scholar 

  124. Kamalakar P, Freeman AI, Higby DJ, Wallace HJ Jr and Sinks LF: Clinical response and toxicity with cis-dichlorodiammineplatinum (II) in children. Cancer Treat Rep 61: 835–839, 1977.

    PubMed  CAS  Google Scholar 

  125. Kaul BK, Singhal GD and Mehrotra ML: Ewing’s sarcoma of lumbar spine–A case report. Ind Pediatr 11: 635–637, 1974.

    CAS  Google Scholar 

  126. Kies MS and Kennedy PS: Central nervous system involvement in Ewing’s sarcoma. Ann Int Med 89: 226–227, 1978.

    PubMed  CAS  Google Scholar 

  127. Kinsella TJ, Glaubiger D, Diesseroth A, Makuch R, Waller B, Pizzo P and Glatstein E: Intensive combined modality therapy including low-dose TBI in high-risk Ewing’s sarcoma patients. Int J Rad Oncol Biol Phys 9: 1955–1960, 1983.

    CAS  Google Scholar 

  128. Kinsella TJ, Loeffler JS, Fraass BA and Tepper J: Extremity preservation by combined modality therapy in sarcomas of the hand and foot: An analysis of local control, disease free survival and functional result. Int J Rad Oncol Biol Phys 9: 1115–1119, 1983.

    CAS  Google Scholar 

  129. Kinsella TJ, Triche TJ, Dickman PS, Costa J, Tepper JE and Glaubiger D: Extraskeletal Ewing’s sarcoma: Results of combined modality treatment. J Clin Oncol 1: 489–495, 1983.

    PubMed  CAS  Google Scholar 

  130. Kissane JM, Askin FB, Foulkes M, Stratton LB and Shirley SF: Ewing’s sarcoma of bone: Clinicopathologic aspects of 303 cases from the intergroup Ewing’s sarcoma study. Human Pathol 14: 773–779, 1983.

    CAS  Google Scholar 

  131. Kissane JM, Askin FB, Nesbit ME Jr, Vietti TJ, Burgert EO Jr, Cangir A, Gehan EA, Perez CA, Pritchard DJ and Tefft M: Sarcomas of bone in childhood: Pathologic aspects. Nat Cancer Inst Mono 56: 29–41, 1981.

    Google Scholar 

  132. Kliman M, Harwood AR, Jenkin RD, Cummings BJ, Langer F, Quirt I and Fornasier VL: Radical radiotherapy as primary treatment for Ewing’s sarcoma distal to the elbow and knee. Clin Ortho Rel Res 165: 233–238, 1982.

    Google Scholar 

  133. Kofman S, Perna CP and Economou SG: Mithramycin in the treatment of metastatic Ewing’s sarcoma. Cancer 31: 889–893, 1973.

    PubMed  CAS  Google Scholar 

  134. Komp DM, Land W, Nitschke R, Cangir A and Dyment P: 5-(3,3-bis(2-chloroethyl)1-triazeno)imidazole-4-carboxamide (NSC-82196) in the treatment of childhood malignancy. Cancer Chemo Rep 59: 371–376, 1975.

    CAS  Google Scholar 

  135. Krivit W and Bentley HP Jr: Use of 5-fluorouracil in the management of advanced malignancies in childhood. Am J Dis Child 100: 217–227, 1960.

    PubMed  CAS  Google Scholar 

  136. Kumar AP, Green A, Smith JW and Pratt CB: Combined therapy for malignant tumors of the chest wall in children. J Pediatr Surg 12: 991–999, 1977.

    PubMed  CAS  Google Scholar 

  137. Lattman I: A review of Ewing’s tumour with case reports. Br J Radiol 7: 194–207, 1934.

    Google Scholar 

  138. Lavalle G, Lemarbre L, Bouchard R, Beauregard CG and Dussault R: Ewing’s sarcoma in adults. J Can Assoc Radiol 30: 223–227, 1979.

    Google Scholar 

  139. Lazarus HM, Herzig RH, Graham-Pole J, Wolff SN, Phillips GL, Strandjord S, Hurd D, Forman W, Gordon EM, Coccia P, Gross S and Herzig GP: Intensive melphalan chemotherapy and cryopreserved autologous bone marrow transplantation for the treatment of refractory cancer. J Clin Oncol 1: 359–367, 1983.

    PubMed  CAS  Google Scholar 

  140. Legge D, Ennis JT and Dempsey J: Percutaneous needle biopsy in the managment of solitary lesions of bone. Clin Radiol 29: 497–500, 1978.

    PubMed  CAS  Google Scholar 

  141. Lewis RJ, Marcove RC and Rosen G: Ewing’s sarcoma–Functional effects of radiation therapy. J Bone. Joint Surg 59-A: 325–331, 1977.

    Google Scholar 

  142. Li FP, Tu J-T, Liu F-S and Shiang EL: Rarity of Ewing’s sarcoma in China. Lancet 1:1255, 1980 (Letter).

    Google Scholar 

  143. Li WK, Lane JM, Rosen G, Marcove RC, Caparros B, Huvos A and Groshen S: Pelvic Ewing’s sarcoma. J Bone Joint Surg 65-A: 738–747, 1983.

    Google Scholar 

  144. Lichtenstein L and Jaffe HL: Ewing’s sarcoma of bone. Am J Pathol 23: 43–77, 1947.

    PubMed  CAS  Google Scholar 

  145. Llombart-Bosch A, Blache R and Peydro-Olaya A: Ultrastructural study of 28 cases of Ewing’s sarcoma: Typical and atypical forms. Cancer 41: 1362–1373, 1978.

    PubMed  CAS  Google Scholar 

  146. Llombart-Bosch A, Peydro-Olaya A and Gomar F: Ultrastructure of one Ewing’s sarcoma of bone with endothelial character and a comparative review of the vessels in 27 cases of typical Ewing’s sarcoma. Pathol Res Pract 167: 71–87, 1980.

    PubMed  CAS  Google Scholar 

  147. Lombardi F, Lattuada A, Gasparini M, Gianni C and Marchesini R: Sequential half-body irradiation as systemic treatment of progressive Ewing sarcoma. Int J Rad Oncol Biol Phys 8: 1679–1682, 1982.

    CAS  Google Scholar 

  148. Lombardi F, Gasparini M, Gianni C, Petrillo R, Tesoro-Tess JD, Volterrani F and Musumeci R: Ewing’s sarcoma: An approach to radiological diagnosis. Tumori 65: 389–399, 1979.

    PubMed  CAS  Google Scholar 

  149. Macintosh DJ, Price CHG and Jeffree GM: Ewing’s tumour. J Bone Joint Surg 57-B: 331–340, 1975.

    Google Scholar 

  150. Malangoni MA, Ofstein LC, Grosfeld JL, Weber TR, Eigen H and Baehner RL: Survival and pulmonary function following chest wall resection and reconstruction in children. J Pediatr Surg 15: 906–912, 1980.

    PubMed  CAS  Google Scholar 

  151. Mallory TB, Castleman B and Parris EE: Case records of the Massachusetts General Hospital (32091). New Engl J Med 234: 304–307, 1932.

    Google Scholar 

  152. Mankin HJ, Lange TA and Spanier SS: The hazards of biopsy in patients with malignant primary bone and soft-tissue tumors. J Bone Joint Surg 64-A: 1121–1127, 1982.

    Google Scholar 

  153. Marsa GW and Johnson RE: Altered pattern of metastases following treatment of Ewing’s sarcoma with radiotherapy and adjuvant chemotherapy. Cancer 27: 1051–1054, 1971.

    PubMed  CAS  Google Scholar 

  154. Marsden HB and Steward JK: Ewing’s tumours and neuroblastomas. J Clin Pathol 17: 411–417, 1964.

    PubMed  CAS  Google Scholar 

  155. McCormack LJ, Dockerty MB and Ghormley RK: Ewing’s sarcoma. Cancer 5: 8599, 1952.

    Google Scholar 

  156. McDougall A: Malignant tumour at site of bone plating. J Bone Joint Surg 38B: 709–713, 1956.

    Google Scholar 

  157. McKeen EA, Hanson MR, Mulvihill JJ and Glaubiger DL: Birth defects with Ewing’s sarcoma. New Engl J Med 309:1522, 1983 (Letter).

    Google Scholar 

  158. McSwain B, Byrd BF and Inman WO Jr: Ewing’s tumor. Surg Gynecol Obstet 89: 209–221, 1949.

    PubMed  CAS  Google Scholar 

  159. McWhirter WR: Personal communication.

    Google Scholar 

  160. McWhirter WR and Bacon JE: Incidence of childhood tumours in Queensland. Br J Cancer 44: 637–642, 1981.

    PubMed  CAS  Google Scholar 

  161. Mehta Y and Hendrickson FE: CNS involvement in Ewing’s sarcoma. Cancer 33: 859–862, 1974.

    PubMed  CAS  Google Scholar 

  162. Meister P and Gokel JM: Extraskeletal Ewing’s sarcoma. Virch Arch Path Anat Histol 378: 173–179, 1978.

    CAS  Google Scholar 

  163. Melnick PJ: Histogenesis of Ewing’s sarcoma of bone. Am J Cancer 19: 353–363, 1933.

    Google Scholar 

  164. Mendenhall CM, Marcus RB Jr, Enneking WF, Springfield DS, Thar TL and Million RR: The prognostic significance of soft tissue extension in Ewing’s sarcoma. Cancer 51: 913–917, 1983.

    PubMed  CAS  Google Scholar 

  165. Millburn LF, O’Grady L and Hendrickson FR: Radical radiation therapy and total body irradiation in the treatment of Ewing’s sarcoma. Cancer 22: 919–925, 1968.

    PubMed  CAS  Google Scholar 

  166. Miller RW: Deaths from childhood leukemia and solid tumors among twins and other sibs in the United States, 1960–67. J Nat Cancer Inst 46: 203–209, 1971.

    PubMed  CAS  Google Scholar 

  167. Miller RW and Dalager NA: U.S. childhood cancer deaths by cell type. 1960–68. J Pediatr 85: 664–668, 1974.

    PubMed  CAS  Google Scholar 

  168. Morgan SK and Thurman WG: Ewing’s sarcoma in children. Clin Pediatr 9: 37–41, 1970.

    CAS  Google Scholar 

  169. Murray IPC: Bone scanning in the child and young adult. Skeletal Radiol 5: 114, 1980.

    Google Scholar 

  170. Nascimento AG, Cooper KL, Unni KK, Dahlin DC and Pritchard DJ: A clinicopathologic study of 20 cases of large-cell (atypical) Ewing’s sarcoma of bone. Am J Surg Pathol 4: 29–36, 1980.

    PubMed  CAS  Google Scholar 

  171. Navas-Palacios JJ, Aparicio-Duque R and Valdes MD: On the histogenesis of Ewing’s sarcoma. Cancer 53: 1882–1901, 1984.

    PubMed  CAS  Google Scholar 

  172. Nesbit ME Jr, Perez CA, Tefft M, Burgert EO Jr, Vietti TJ, Kissane J, Pritchard DJ and Gehan EA: Multimodal therapy for the managment of primary, non-metastatic Ewing’s sarcoma of bone: An intergroup study. Nat Cancer Inst Mono 56: 255–262, 1981.

    Google Scholar 

  173. Nielsen SW: Comparative pathology of bone tumors in animals with particular emphasis on the dog. IN. Malignant Bone Tumors. E Grundman (ed), Springer-Verlag, Berlin, 1976, pp 3–16.

    Google Scholar 

  174. Nitschke R, Fagundo R, Berry DH and Falletta JM: Weekly administration of cisdichlorodiammineplatinum (II) in childhood solid tumors: A southwest oncology group study. Cancer Treat Rep 63: 497–499, 1979.

    PubMed  CAS  Google Scholar 

  175. Oldham RK and Pomeroy TC: Treatment of Ewing’s sarcoma with adriamycin (NSC-123127). Cancer Chemo Rep 56: 635–639, 1972.

    CAS  Google Scholar 

  176. Ottolenghi CE: Diagnosis of orthopaedic lesions by aspiration biopsy: Results of 1061 punctures. J Bone Joint Surg 37A: 443–464, 1955.

    PubMed  Google Scholar 

  177. Palma J, Gailani S, Freeman A, Sinks L and Holland JF: Treatment of metastatic Ewing’s sarcoma with BCNU. Cancer 30: 909–913, 1972.

    PubMed  CAS  Google Scholar 

  178. Pant GC, Sanyal B, Salmi K, Tull SM and Srivastava TP: Ewing’s sarcoma: A combined approach in the management. Clin Radiol 32: 471–474, 1981.

    PubMed  CAS  Google Scholar 

  179. Paradise JE, Raney RB Jr and Whitaker LA: Progressive facial hemiatrophy. Am J Dis Child 134: 1065–1067, 1980.

    PubMed  CAS  Google Scholar 

  180. Pastore G, Magnani C, Zanetti R and Terracini B: Incidence of cancer in children in the province of Torino (Italy) 1967–78. Eur J Cancer 17: 1337–1341, 1981.

    CAS  Google Scholar 

  181. Pendergrass TW, Foulkes MA, Robison LL and Nesbit ME: Stature and Ewing’s sarcoma in childhood. Am J Pediatr Hematol/Oncol 6: 33–39, 1984.

    CAS  Google Scholar 

  182. Perez CA, Razek A, Tefft M, Nesbit M, Burgert EO, Kissane J, Vietti TJ and Gehan EA: Analysis of local tumor control in Ewing’s sarcoma. Cancer 40: 2864–2873, 1977.

    PubMed  CAS  Google Scholar 

  183. Perez CA, Tefft M, Nesbit ME Jr, Burgert EO Jr, Vietti TJ, Kissane J, Pritchard DJ and Gehan EA: Radiation therapy in the multimodal management of Ewing’s sarcoma of bone: Report of the intergroup Ewing’s sarcoma study. Nat Cancer Inst Mono 56: 263–271, 1981.

    Google Scholar 

  184. Perez CA, Tefft M, Nesbit M, Burgert EO Jr, Vietti T, Kissane J, Pritchard DJ and Gehan EA: The role of radiation therapy in the management of non-metastatic Ewing’s sarcoma of bone. Report of the intergroup Ewing’s sarcoma study. Int J Rad Oncol Biol Phys 7: 141–149, 1981.

    CAS  Google Scholar 

  185. Phelan JT and Cabrera A: Ewing’s sarcoma. Surg Gynecol Obstet 118: 795–800, 1964.

    PubMed  CAS  Google Scholar 

  186. Phillips TL and Sheline GE: Radiation therapy of malignant bone tumors. Radiology 92: 1537–1545, 1969.

    PubMed  CAS  Google Scholar 

  187. Pilepich MV, Vietti TJ, Nesbit ME, Tefft M, Kissane J, Burgert EO and Pritchard D: Radiotherapy and combination chemotherapy in advanced Ewing’s sarcoma–Intergroup study. Cancer 47: 1930–1936, 1981.

    PubMed  CAS  Google Scholar 

  188. Pilepich MV, Vietti TJ, Nesbit ME, Tefft M, Kissane J, Burgert O, Pritchard D and Gehan EA: Ewing’s sarcoma of the vertebral column. Int J Rad Oncol Biol Phys 7: 27–31, 1981.

    CAS  Google Scholar 

  189. Pinkel D: Chlorambucil in childhood cancer. Cancer 14: 36–41, 1961.

    PubMed  CAS  Google Scholar 

  190. Pinkel D: Cyclophosphamide in children with cancer. Cancer 15: 42–49, 1962.

    PubMed  CAS  Google Scholar 

  191. Pomeroy TC and Johnson RE: Prognostic factors for survival in Ewing’s sarcoma. Am J Roentgenol 123: 598–606, 1975.

    CAS  Google Scholar 

  192. Potdar GG: Ewing’s tumour. Clin Radiol 22: 528–533, 1971.

    PubMed  CAS  Google Scholar 

  193. Povysil C and Mateiovsky Z: Ultrastructure of Ewing’s tumor. Virchows Arch A Pathol Anat Histol 374: 303–316, 1977.

    PubMed  CAS  Google Scholar 

  194. Pratt CB, Etcubanas E, Thompson E, Hayes FA, Champion JE and Crom DB: Mitoxantrone (dihydroxy anthracenedione, DHAD) - Phase II study in pediatric patients. Proc Am Assoc Cancer Res 23: 122, 1982 (Abstract).

    Google Scholar 

  195. Pratt CB, Hayes A, Green AA, Evans WE, Senzer N, Howarth CB, Ransom JL and Crom W: Pharmacokinetic evaluation of cisplatin in children with malignant solid tumors: A phase II study. Cancer Treat Rep 65: 1021–1026, 1981.

    PubMed  CAS  Google Scholar 

  196. Pratt CB, Roberts D, Shanks E and Warmath EL: Response, toxicity and pharmacokinetics of high-dose methotrexate (NSC-740) with citrovorum factor (NSC3590) rescue for children with osteosarcoma and other malignant tumors. Cancer Chemo Rep Part 3 6: 13–18, 1975.

    Google Scholar 

  197. Pratt CB and Shanks EC: Doxorubicin in treatment of malignant solid tumors in children. Am J Dis Child 127: 534–536, 1974.

    PubMed  CAS  Google Scholar 

  198. Pritchard DJ, Dahlin DC, Dauphine RT, Taylor WF and Beaubout JW: Ewing’s sarcoma. J Bone Joint Surg 57-A: 10–16, 1975.

    Google Scholar 

  199. Ragab AH, Sutow WW, Komp DM, Starling KA, Lyon GM Jr and George S: Adriamycin in the treatment of childhood solid tumors. Cancer 36: 1567–1571, 1975.

    PubMed  CAS  Google Scholar 

  200. Rand RW and Rand CW: Intraspinal Tumors of Childhood. Charles C Thomas, Springfield, 1960, pp 249–256.

    Google Scholar 

  201. Razek A, Perez CA, Tefft M, Nesbit M, Vietti T, Burgert EO Jr, Kissane J, Pritchard DJ and Gehan EA: Intergroup Ewing’s sarcoma study. Cancer 46: 516–521, 1980.

    PubMed  CAS  Google Scholar 

  202. Reamen GH, Poplack DG, Glaubiger DL and Levine AS: Phase II study of 5azacytidine in sarcomas of bone. Am J Clin Oncol 5: 411–415, 1982.

    Google Scholar 

  203. Reiman RE, Rosen G, Gelbard AS, Benua RS and Laughlin JS: Imaging of primary Ewing’s sarcoma with 13N-L-glutamate. Radiology 142: 495–500, 1982.

    PubMed  CAS  Google Scholar 

  204. Rivera G, Avery T and Pratt C: 4’–demethylepipodophyllotoxin–9–(4,6–0–2–thenylidene–beta–D–glucopyranoside) (NSC–122819); VM–26) and 4’–demethylepipodophyllotoxin–9–(4, 6–0–ethylidene–beta–D–glucopyranoside) (NSC–141540; VP–16–213) in childhood cancer: Preliminary observations. Cancer Chemo Rep 59: 743 – 749, 1975.

    CAS  Google Scholar 

  205. Rodgers BM, Talbert JL and Alexander JA: Pulmonary metastases in childhood sarcoma. Ann Thorac Surg 29: 410–414, 1980.

    PubMed  CAS  Google Scholar 

  206. Roessner A, Voss B, Rauterberg J, Immenkamp M and Grundmann E: Biologic characterization of human bone tumors. Cancer Res Clin Oncol 104: 171–180, 1982.

    CAS  Google Scholar 

  207. Rosen G, Caparros B, Mosende C, McCormick B, Huvos AG and Marcove RC: Curability of Ewing’s sarcoma and considerations for future therapeutic trials. Cancer 41: 888–899, 1978.

    PubMed  CAS  Google Scholar 

  208. Rosen G, Caparros B, Nirenberg A, Marcove RC, Huvos AG, Kosloff C, Lane J and Murphy ML: Ewing’s sarcoma: Ten-year experience with adjuvant chemotherapy. Cancer 47: 2204–2213, 1981.

    PubMed  CAS  Google Scholar 

  209. Rosen G, Juergens H, Caparros B, Nirenberg A, Huvos AG and Marcove RC: Combination chemotherapy (T-6) in the multidisciplinary treatment of Ewing’s sarcoma. Nat Cancer Inst Mono 56: 289–299, 1981.

    Google Scholar 

  210. Rosen G, Wollner N, Tan C, Wu SJ, Hajdu SI, Cham W, D’Angio GJ and Murphy ML: Disease-free survival in children with Ewing’s sarcoma treated with radiation therapy and adjuvant four-drug sequential chemotherapy. Cancer 33: 384–393, 1974.

    PubMed  CAS  Google Scholar 

  211. Russin LA, Robinson MJ, Engle HA and Sonni A: Ewing’s sarcoma of the lumbar spine: A case report of long-term survival. Clin Ortho 164: 126–129, 1982.

    Google Scholar 

  212. Samuels ML and Howe CD: Cyclophosphamide in the management of Ewing’s sarcoma. Cancer 20: 961–966, 1967.

    PubMed  CAS  Google Scholar 

  213. Schajowicz F: Ewing’s sarcoma and reticulum-cell sarcoma of bone. J Bone Joint Surg 41-A: 349–356, 1959.

    PubMed  CAS  Google Scholar 

  214. Schajowicz F and Derqui JC: Puncture biopsy in lesions of the locomotor system: Review of results in 4050 cases, including 941 vertebral punctures. Cancer 21: 531–548, 1968.

    PubMed  CAS  Google Scholar 

  215. Schajowicz F and Hokama J: Aspiration (puncture or needle) biopsy in bone lesions. IN. Malignant Bone Tumors. E Grundman (ed), Springer-Verlag, Berlin, 1976, pp 376–382.

    Google Scholar 

  216. Selawry OS, Holland JF and Wolman IJ: Effect of vincristine (NSC-67574) on malignant solid tumors in children. Cancer Chemo Rep 52: 497–500, 1968.

    CAS  Google Scholar 

  217. Senyszyn JJ, Johnson RE and Curran RE: Treatment of metastatic Ewing’s sarcoma with actinomycin D (NSC-3053). Cancer Chemo Rep 54: 103–107, 1970.

    CAS  Google Scholar 

  218. Shibota Y, Nakagawa Y, Koizumi A and Kagawa Y: Ewing’s sarcoma in Japan. Tohoku J Exp Med 81: 56–64, 1963.

    PubMed  CAS  Google Scholar 

  219. Simon MA and Bos GD: Epiphyseal extension of metaphyseal osteosarcoma in skeletally immature individuals. J Bone Joint Surg 62-A: 195–204, 1980.

    Google Scholar 

  220. Simonati A, Vio M, Iannucci AM, Bricolo A and Rizzuto N: Lumbar epidural Ewing sarcoma. J Neurol 225: 67–72, 1981.

    PubMed  CAS  Google Scholar 

  221. Soule EH, Newton W Jr, Moon TE and Tefft M: Extraskeletal Ewing’s sarcoma. Cancer 42: 259–264, 1978.

    PubMed  CAS  Google Scholar 

  222. Staalman CR: Ewing’s sarcoma in rib. J Belge Radiol 65: 329–337, 1982.

    PubMed  CAS  Google Scholar 

  223. Stout AP: A discussion of the pathology and histogenesis of Ewing’s tumor of bone marrow. Am J Roentgenol 50: 334–342, 1943.

    Google Scholar 

  224. Sundaresan N, Rosen G, Fortner JG, Lane JM and Hilaris BS: Preoperative chemotherapy and surgical resection in the management of posterior paraspinal tumors. J Neurosurg 58: 446–450, 1983.

    PubMed  CAS  Google Scholar 

  225. Sutow WW and Sullivan MP: Cyclophosphamide therapy in children with Ewing’s sarcoma. Cancer Chemo Rep 23: 55–60, 1962.

    CAS  Google Scholar 

  226. Sutow WW, Vietti TJ, Fernbach DJ, Lane DM, Donaldson MH and Lonsdale D: Evaluation of chemotherapy in children with metastatic Ewing’s sarcoma and osteogenic sarcoma. Cancer Chemo Rep 55: 67–78, 1971.

    CAS  Google Scholar 

  227. Sutow WW, Wilbur JR, Vietti TJ, Vuthibhagdee P, Fujimoto T and Watanabe A: Evaluation of dosage schedules of mitomycin C (NSC-26980) in children. Cancer Chemo Rep 55: 285–289, 1971.

    CAS  Google Scholar 

  228. Taber DS, Libshitz HI and Cohen M: Treated Ewing’s sarcoma: Radiographic appearance in response, recurrence and new primaries. Am J Roentgenol 140: 753–758, 1983.

    CAS  Google Scholar 

  229. Takahashi K, Sato T and Kojima M: Cytological characterization and histogenesis of Ewing’s sarcoma. Acta Pathol Jap 26: 167–190, 1976.

    Google Scholar 

  230. Tan C, Rosen G, Ghavimi F, Haghbin M, Helson L, Wollner N and Murphy ML: Adriamycin (NSC-123127) in pediatric malignancies. Cancer Chemo Rep Part 3 6: 259–266, 1975.

    Google Scholar 

  231. Tan C, Tasaka H, Yu K-P, Murphy ML and Karnofsky DA: Daunomycin an antitumor antibiotic in the treatment of neoplastic disease. Cancer 20: 333–353, 1967.

    PubMed  CAS  Google Scholar 

  232. Tan. CTC, Hancock CH, Mondora A and Hoffman NW: Phase I study of aziridinylbenzoquinone (AZQ, NSC-182986) in children with cancer. Cancer Res 44: 831–835, 1984.

    PubMed  CAS  Google Scholar 

  233. Tayton KJJ: Ewing’s sarcoma at the site of a metal plate. Cancer 45: 413–415, 1980.

    PubMed  CAS  Google Scholar 

  234. Tefft M, Razek A, Perez CA, Burgert EO Jr, Gehan EA, Griffin P, Kissane J, Vietti T and Nesbit M: Local control and survival related to radiation dose and volume and to chemotherapy in non-metastatic Ewing’s sarcoma of pelvic bones. Int J Rad Oncol Biol Phys 4: 367–372, 1978.

    CAS  Google Scholar 

  235. Tefft M, Vawter GF and Mitus A: Paravertebral “round cell” tumors in children. Radiology 92: 1501–1509, 1969.

    PubMed  CAS  Google Scholar 

  236. Telles NC, Rabson AS and Pomeroy TC: Ewing’s sarcoma: An autopsy study. Cancer 41: 2321–2329, 1978.

    PubMed  CAS  Google Scholar 

  237. Tepper J, Glaubiger D, Lichter A, Wackenhut J and Glatstein E: Local control of Ewing’s sarcoma of bone with radiotherapy and combination chemotherapy. Cancer 46: 1969–1973, 1980.

    PubMed  CAS  Google Scholar 

  238. Teppo L: Personal communication.

    Google Scholar 

  239. Theilen GH and Madewell BR: Tumors of the skeleton. IN. Veterinary Cancer Medicine GH Theilen and BR Madewell (ed). Lea and Febiger, Philadelphia, 1979, pp 289–306.

    Google Scholar 

  240. Thomas PRM, Foulkes MA, Gilula LA, Burgert EO, Evans RG, Kissane J, Nesbit ME, Pritchard DJ, Tefft M and Vietti TJ: Primary Ewing’s sarcoma of the ribs. Cancer 51: 1021–1027, 1983.

    PubMed  CAS  Google Scholar 

  241. Thommesen P, Frederiksen P, Lowhagen T and Willems JS: Needle aspiration biopsy in the diagnosis of lytic bone lesions in histiocytosis X, Ewing’s sarcoma and neuroblastoma. Acta Radiol Oncol 17: 145–149, 1978.

    CAS  Google Scholar 

  242. Tilly H, Bastard C, Chevallier B, Halkin E and Monconduit M: Chromosomal abnormalities in secondary Ewing’s sarcoma. Lancet 2:812, 1984 (Letter).

    PubMed  CAS  Google Scholar 

  243. Tjalma RA: Canine bone sarcoma: Estimation of relative risk as a function of body size. J Nat Cancer Inst 36: 1137–1150, 1966.

    PubMed  CAS  Google Scholar 

  244. Triche TJ and Ross WE: Glycogen-containing neuroblastoma with clinical and pathological features of Ewing’s sarcoma. Cancer 41: 1425–1432, 1978.

    PubMed  CAS  Google Scholar 

  245. Trigg ME, Glaubiger D and Nesbit ME Jr: The frequency of isolated CNS involvement in Ewing’s sarcoma. Cancer 49: 2404–2409, 1982.

    PubMed  CAS  Google Scholar 

  246. Tschappeler H and Vock P: Computed tomography and bone tumors in children. Ann Radiol 25: 19–24, 1982.

    PubMed  CAS  Google Scholar 

  247. Turbergen DG: Personal communication.

    Google Scholar 

  248. Turc-Carel C, Philip I, Berger M-P, Philip T and Lenoir GM: Chromosome study of Ewing’s sarcoma (ES) cell lines. Consistency of a reciprocal translocation t(11;22)(q24;q12). Cancer Genet Cytogenet 12: 1–9, 1984.

    PubMed  CAS  Google Scholar 

  249. Upshaw JE, McDonald JR and Ghormley RK: Extension of primary neoplasms of bone to bone marrow. Surg Gynecol Obstet 89: 704–714, 1949.

    PubMed  CAS  Google Scholar 

  250. Vanel D, Contesso G, Couanet D, Piekarski JD, Sazzazin D and Masselot J: Computed tomography in the evaluation of 41 cases of Ewing’s sarcoma. Skeletal Radiol 9: 8–13, 1982.

    PubMed  CAS  Google Scholar 

  251. Wang CC and Schulz MD: Ewing’s sarcoma. New Engl J Med 248: 571–576, 1953.

    PubMed  CAS  Google Scholar 

  252. Wang JJ, Holland JF and Sinks LF: Phase II study of adriamycin (NSC-123127) in childhood solid tumors. Cancer Chemo Rep Part 3 6: 267–270, 1975.

    Google Scholar 

  253. Watts HG: Surgical management of malignant bone tumors in children. IN. Bone Tumors in Children. N Jaffe (ed), PSG Publishing Company Inc, Littleton, 1979 pp 131–133.

    Google Scholar 

  254. Whang-Peng J, Triche TJ, Knutsen T, Miser J, Douglass EC and Israel MA: Chromosome translocation in peripheral neuroepithelioma. New Engl J Med 311: 584–585, 1984.

    PubMed  CAS  Google Scholar 

  255. Wharam MD, Kaizer H, Leventhal BG, Munoz L, Tutschka PJ, Santos GW, Elfenbein GJ and Order SE: Systemic irradiation for selected stage IV and recurrent pediatric solid tumors: Method, toxicity and preliminary results. Int J Rad Oncol Biol Phys 6: 217–223, 1980.

    CAS  Google Scholar 

  256. Whitehouse GH and Griffiths GJ: Roentgenologic aspects of spinal involvement by primary and metastatic Ewing’s tumor. J Can Assoc Radiol 27: 290–297, 1976.

    PubMed  CAS  Google Scholar 

  257. Wigger HJ, Salazar GH and Blanc WA: Extraskeletal Ewing sarcoma. Arch Pathol Lab Med 101: 446–449, 1977.

    PubMed  CAS  Google Scholar 

  258. Williams AO: Tumors of childhood in Ibadan, Nigeria. Cancer 36: 370–378, 1975.

    PubMed  CAS  Google Scholar 

  259. Willis RA: Metastatic neuroblastoma in bone presenting the Ewing syndrome with a discussion of “Ewing’s sarcoma”. Am J Pathol 16: 317–331, 1940.

    PubMed  CAS  Google Scholar 

  260. Willis RA: Pathology of Tumours. Third Edition, Butterworths, Washington, 1960, pp 691.

    Google Scholar 

  261. Winham AJ: Ewing’s tumor of a rib with pulmonary metastases. Am J Roentgenol 71: 445–447, 1954.

    CAS  Google Scholar 

  262. Wolman IJ and Gens RD: Progress report on the use of 5-fluoro-2’-deoxyuridine (5-FUDR) in childhood leukemias and neoplasms. Cancer Chemo Rep 2: 14–15, 1959.

    Google Scholar 

  263. Young JL Jr: Personal communication.

    Google Scholar 

  264. Young JL Jr, Heise HW, Silverberg E and Myers MH: Cancer incidence, survival and mortality for children under 15 years of age. American Cancer Society, New York, 1978, p 8.

    Google Scholar 

  265. Young JL Jr and Miller RW: Incidence of malignant tumors in U.S. children. J Pediatr 86: 254–258, 1975.

    PubMed  Google Scholar 

  266. Zucker JM, Henry-Amar M, Sarrazin D, Blache R, Patte C and Schweisguth O: Intensive systemic chemotherapy in localized Ewing’s sarcoma in childhood. Cancer 52: 415–423, 1983.

    PubMed  CAS  Google Scholar 

  267. Zwartjes W, Lienert E and Gehret P: Combination therapy for the treatment of Ewing’s sarcoma. Proc Am Assoc Cancer Res 19: 406, 1978 (Abstract).

    Google Scholar 

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    Daniel M. Green

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Green, D.M. (1985). Ewings’ Sarcoma. In: Diagnosis and Management of Malignant Solid Tumors in Infants and Children. Developments in Oncology, vol 37. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2623-6_6

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