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Altered Autonomic Modulation of Cardiovascular Function with Adult Aging: Perspectives from Studies Ranging from Man to Cells

  • Chapter
Pathobiology of Cardiovascular Injury

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 49))

Abstract

Cardiovascular performance is determined by the integrated function of multiple interdependent variables (Fig. 1). In addition to coronary blood flow, these include: heart rate; the load or stretch on the myocardial fibers prior to excitation (preload or end-diastolic filling volume); the load during shortening (afterload) which is multifactual and depends not only on aortic pressure but on other determinants of vascular input impedance and also on the ventricular radius; and the effectiveness of myocardial excitation-activationcontraction coupling, sometimes referred to as myocardial “contractility” or the “inotropic” or “contractile state.” Because of the high degree of integration among these multiple determinants of cardiovascular function, a deficit or enhancement of one factor can be compensated for by adjustments in others in order to maintain overall cardiovascular performance within a narrow range to meet the flow or pressure required by the organism at a given moment.

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Author information

Authors and Affiliations

  1. Cardiovascular Section, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA

    E. G. Lakatta

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  1. E. G. Lakatta
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Editor information

Editors and Affiliations

  1. Health Sciences Center, University of Oklahoma, USA

    H. Lowell Stone

  2. Cardiovascular Research Program, Oklahoma Medical Research Foundation, USA

    William B. Weglicki

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© 1985 Martinus Nijhoff Publishing, Boston

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Lakatta, E.G. (1985). Altered Autonomic Modulation of Cardiovascular Function with Adult Aging: Perspectives from Studies Ranging from Man to Cells. In: Stone, H.L., Weglicki, W.B. (eds) Pathobiology of Cardiovascular Injury. Developments in Cardiovascular Medicine, vol 49. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2621-2_32

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  • DOI: https://doi.org/10.1007/978-1-4613-2621-2_32

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9639-3

  • Online ISBN: 978-1-4613-2621-2

  • eBook Packages: Springer Book Archive

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