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Glycolytic Products and Ischemic Myocardial Damage

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Pathobiology of Cardiovascular Injury

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 49))

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Abstract

The biochemical cause of the time dependent transition from reversible to irreversible damage in ischemic myocardium is not known. Tissue damage has been reported to involve alterations in many cellular events, several of which are interrelated. This makes it difficult to distinguish cause and effect relationships. Either or both of the primary factors causing ischemic damage, i.e., decreased oxygen supply and ATP content or accumulation of metabolic products, may initiate a heterogeneous cascade of metabolic and structural alterations that collectively cause irreversible damage. However, the precise nature of this initiating factor is still poorly understood.

This work was supported by NIH grant #HL-18206.

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Author information

Authors and Affiliations

  1. Department of Physiology, The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania, 17033, USA

    L. Grotyohann & J. R. Neely

Authors
  1. L. Grotyohann
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  2. J. R. Neely
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Editors and Affiliations

  1. Health Sciences Center, University of Oklahoma, USA

    H. Lowell Stone

  2. Cardiovascular Research Program, Oklahoma Medical Research Foundation, USA

    William B. Weglicki

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© 1985 Martinus Nijhoff Publishing, Boston

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Grotyohann, L., Neely, J.R. (1985). Glycolytic Products and Ischemic Myocardial Damage. In: Stone, H.L., Weglicki, W.B. (eds) Pathobiology of Cardiovascular Injury. Developments in Cardiovascular Medicine, vol 49. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2621-2_20

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  • DOI: https://doi.org/10.1007/978-1-4613-2621-2_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9639-3

  • Online ISBN: 978-1-4613-2621-2

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