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Carbohydrate and Lipid Metabolism in Ischemia

  • Chapter
Pathobiology of Cardiovascular Injury

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 49))

Abstract

The great majority of energy needs of heart muscle is supplied through the oxidation of fatty acids, lactate and glucose derived from plasma. Long chain fatty acids are oxidized in preference to carbohydrates and normally account for 60–70% of substrate utilized for oxidative metabolism in aerobic hearts. Utilization of glucose and lactate are in part dependent on the availability of alternate substrates and can be appreciably modified by the presence of fatty acids or competitive carbohydrate analogs (1). Glucose per se is probably incapable of supplying adequate amounts of energy in aerobic hearts over long periods of time because of the inability of the myocyte to rapidly remove NADH from the cytosol (2).

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Authors and Affiliations

  1. Cardiology Section, Center for Health Sciences, University of Wisconsin, Madison, Madison, Wisconsin, 53792, USA

    A. J. Liedtke, J. E. Orie & E. J. Toggart

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  1. A. J. Liedtke
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  2. J. E. Orie
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  3. E. J. Toggart
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Editors and Affiliations

  1. Health Sciences Center, University of Oklahoma, USA

    H. Lowell Stone

  2. Cardiovascular Research Program, Oklahoma Medical Research Foundation, USA

    William B. Weglicki

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© 1985 Martinus Nijhoff Publishing, Boston

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Liedtke, A.J., Orie, J.E., Toggart, E.J. (1985). Carbohydrate and Lipid Metabolism in Ischemia. In: Stone, H.L., Weglicki, W.B. (eds) Pathobiology of Cardiovascular Injury. Developments in Cardiovascular Medicine, vol 49. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2621-2_14

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  • DOI: https://doi.org/10.1007/978-1-4613-2621-2_14

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