Advertisement

Carbohydrate and Lipid Metabolism in Ischemia

  • A. J. Liedtke
  • J. E. Orie
  • E. J. Toggart
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 49)

Abstract

The great majority of energy needs of heart muscle is supplied through the oxidation of fatty acids, lactate and glucose derived from plasma. Long chain fatty acids are oxidized in preference to carbohydrates and normally account for 60–70% of substrate utilized for oxidative metabolism in aerobic hearts. Utilization of glucose and lactate are in part dependent on the availability of alternate substrates and can be appreciably modified by the presence of fatty acids or competitive carbohydrate analogs (1). Glucose per se is probably incapable of supplying adequate amounts of energy in aerobic hearts over long periods of time because of the inability of the myocyte to rapidly remove NADH from the cytosol (2).

Keywords

Positron Emission Tomography Myocardial Blood Flow Myocardial Metabolism Serum Free Fatty Acid Fatty Acid Utilization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Montini, J., Bagby, G.J. and Spitzer, J.J. J. Mol. Cell. Cardiol. 13: 903–911, 1981.CrossRefGoogle Scholar
  2. 2.
    Kobayashi, K. and Neely, J.R. Circ. Res. 44:166–175, 1979.PubMedGoogle Scholar
  3. 3.
    Bing, R.J. Physiol. Rev. 45:171–213, 1965PubMedGoogle Scholar
  4. 4.
    Crass, M.F., III. Biochim. Biophys. Acta 80:71–81, 1972.Google Scholar
  5. 5.
    Fritz, I.B. In: Cellular Compartmentalization and Fatty Acid Metabolism, Universitetsforlaget, Oslo, pp. 39–63.Google Scholar
  6. 6.
    Garland, P.B. and Randle P.J. Biochem. J. 93:678–687, 1970.Google Scholar
  7. 7.
    Katz, A.M. and Hecht, H.H. Am. J. Med. 47:497–502, 1969.PubMedCrossRefGoogle Scholar
  8. 8.
    Newsholme, E.A. and Randle P.J. Biochem J. 93:641–651, 1964.PubMedGoogle Scholar
  9. 9.
    Neely, J.R., Rovetto, M.J. and Oram, J.F. Prog. Cardiovasc. Dis. 15:289–329, 1972.PubMedCrossRefGoogle Scholar
  10. 10.
    Neely, J.R. and Morgan, H.E. Annu. Rev. Physiol. 36:413–459, 1974.PubMedCrossRefGoogle Scholar
  11. 11.
    Morgan N.G., Neely J.R. and Lalloue J.S. In: Acute and Long-term Medical Management of Myocardial Ischemia (Eds. A. Hjalmarson and L. Wilhelmsen), Astra Goteborg, 1978, pp. 10–22.Google Scholar
  12. 12.
    Hochachka, P.W., Neely, J.R. and Driedzic, W.R. Fed. Proc. 36:2009–2014, 1977.PubMedGoogle Scholar
  13. 13.
    Liedtke, A.J. Prog. Cardiovasc. Dis. 23:321–336, 1981.PubMedCrossRefGoogle Scholar
  14. 14.
    Opie, L.H. Circ. Res. 38 Supp I:I-52-i-68, 1976.Google Scholar
  15. 15.
    Weiss, E.S., Hoffman, E.J., Phelps, M.E., Welch, N.J., Henry, P.D., TerPogossian, M.M. and Sobel, B.E. Circ. Res. 39:24–32, 1976.PubMedGoogle Scholar
  16. 16.
    Schelbert, H.R., Phelps, M.E., Hoffman, E., Huang, S.C. and Kuhl, D.E. Am. J. Cardiol. 46:1269–1277, 1980.PubMedCrossRefGoogle Scholar
  17. 17.
    Lerch, R.A., Bergmann, S.R., Ambos, H.D., Welch, M.J., Ter-Pogossian, M.M. and Sobel, B.E. Circulation 65:731–738, 1984.CrossRefGoogle Scholar
  18. 18.
    Krivokapich, J., Huang, S.C., Phelps, M.E., Barrio, J.R., Watanabe, C.R., Selin, C.E. and Shine, K.I. Am. J. Physiol. 12:H884–H895, 1982.Google Scholar
  19. 19.
    Schelbert, H.R., Henze, E., Keen, R., Shon, H.R., Hansen, H., Selin, C., Huang, S.C., Barrio, J.R. and Phelps, M.E. Am. Heart J. 106:736–750, 1983.PubMedCrossRefGoogle Scholar
  20. 20.
    Lerch, R.A., Ambos, H.D., Bergmann, S.R., Welch, M.J., Ter-Pogossian, M.M. and Sobel, B.E. Circulation 64:689–699, 1981.PubMedCrossRefGoogle Scholar
  21. 21.
    Sobel, B.E., Weiss, E.S., Welch, M.J., Siegel, B.A. and Ter-Pogossian, M.M. Circulation 55:853–857, 1977.PubMedGoogle Scholar
  22. 22.
    Ter-Pogossian, M.M., Klein, M.S., Markham, J., Roberts, R. and Sobel, B.E. Circulation 61:242–255, 1980.PubMedGoogle Scholar
  23. 23.
    Geltman, E.M., Biello, D., Welch, M.J., Ter-Pogossian, M.M., Roberts, R. and Sobel, B.E. Circulation 65:747–755, 1982.PubMedCrossRefGoogle Scholar
  24. 24.
    Marshall, R.C., Tillisch, J.H., Phelps, M.E., Huang, S.C., Carson, R., Henze, H. and Schelbert, H.R. Circulation 67:766–778, 1983.PubMedCrossRefGoogle Scholar
  25. 25.
    Rentrop, P., Blanke, H., Karsch, K.R., Kaiser, H., Kostering, H. and Leitz, C.K. Circulation 63:307–317, 1981.PubMedCrossRefGoogle Scholar
  26. 26.
    Markis, J.E., Malagold, M., Parker, J.A., Silverman, K.J., Barry, W.H., Als, A.V., Paulin, S., Grossman, W. and Braunwald, E. N. Engl. J. Med. 305:777–782, 1981.CrossRefGoogle Scholar
  27. 27.
    Bergmann, S.R., Lerch, R.A., Fox, K.A., Ludbrook, P.A., Welch, M.J., TerPogossian, M.M. and Sobel, B.E. Am. J. Med. 73:573–581, 1982.PubMedCrossRefGoogle Scholar
  28. 28.
    Katz, A.M. and Messineo, F.C. Circ. Res. 48:1–16, 1981.PubMedGoogle Scholar
  29. 29.
    Corr, P.B., Gross, R.W. and Sobel, B.E. Circ. Res. 55:135–154.Google Scholar
  30. 30.
    Oliver, M.F., Kurien, V.A. and Greenwood, T.W. Lancet 1:710–714, 1968.PubMedCrossRefGoogle Scholar
  31. 31.
    Wood, J.M., Bush, B., Pitts, B.J.R. and Schwartz, A. Biochem. Biophys. Res. Commun. 74:677–684, 1977.PubMedCrossRefGoogle Scholar
  32. 32.
    Owens, K., Kennett, S.S. and Weglicki, W.B. Am. J. Physiol. 11:H456–H461, 1982.Google Scholar
  33. 33.
    Rodis, S.L., D’Amata, P.H., Koch, E. and Vahouny, G.V. Proc. Soc. Exp. Biol. Med. 133:973–977, 1970.PubMedGoogle Scholar
  34. 34.
    Liedtke, A.J., Nellis, S.H. and Whitesell, L.F. Circ. Res. 48:859–866, 1981.PubMedGoogle Scholar
  35. 35.
    Kader, M.M.A., Hay, A.A., Kamel, G., Aziz, M.T.A. and Fayek, K.I. Acta Biol. Med. Ger. 24:1–11, 1970.PubMedGoogle Scholar
  36. 36.
    Ferrari, R., Cucchini, S. and Visioli, O. Int. J. Cardiol. 5:213–216, 1984.PubMedCrossRefGoogle Scholar
  37. 37.
    Vacha, G.M., Giorcelli, G., Siliprandi, N. and Corsi, M. Am. J. Clin. Nutr. 38:532–540, 1983.PubMedGoogle Scholar
  38. 38.
    Hulsmann, W.C., Stam, H. and Maccari, F. Biochim. Biophys. Acta 713:3945, 1982.Google Scholar
  39. 39.
    Wu-Rideout, M.Y.C., Woldegiorges, G., Shrago, E. and Elson, C. Biochem. Pharmacol. 27:2425–2429, 1978.PubMedCrossRefGoogle Scholar
  40. 40.
    Lopaschuk, G.D. and Neely, J.R. Fed. Proc. 43:903, 1984.Google Scholar
  41. 41.
    Bremer, J. and Norum, K.R. J. Biol. Chem. 242:1744–1748, 1967.Google Scholar
  42. 42.
    McGarry, J.D., Leatherman, G.F. and Foster, D.W. J. Biol. Chem. 253: 4128–4136, 1978.Google Scholar
  43. 43.
    Mills, S.E., Foster, D.W. and McGarry, J.D. Fed. Proc. 42:1855, 1983.Google Scholar
  44. 44.
    Mills, S.E., Foster, D.W. and McGarry, J.D. Fed. Proc. 43:823, 1984.Google Scholar
  45. 45.
    Bielefeld, D.R., Vary, T.C. and Neely, J.R. Fed. Proc. 42:1258, 1983.Google Scholar
  46. 46.
    Higgins, A.J., Morville, M., Burges, R.A. and Blackburn, K.J. Biochem. Biophys. Res. Commun. 100:291–296, 1982.CrossRefGoogle Scholar
  47. 47.
    Liedtke, A.J., Nellis, S.H. and Mjos, O.D. Am. J. Physiol., in press, 1984.Google Scholar
  48. 48.
    Tutwiler, G.F., Mohrbacher, R. and Winston, H.O. Diabetes 28:242–248, 1979.PubMedGoogle Scholar
  49. 49.
    Joseph, J.M., Wallace, N.H. and Tutwiler, G.F. Fed. Proc. 43:410, 1984.Google Scholar
  50. 50.
    Sherratt, H.S.A., Gatley, S.J., DeGrado, T.R., Ng, C.K. and Holden, J.E. Biochem. Biophys. Res. Commun. 117:653–657, 1983.PubMedCrossRefGoogle Scholar
  51. 51.
    Rosen, P. and Reinauer, H. Metabolism 33:175–185, 1984.CrossRefGoogle Scholar
  52. 52.
    Pande, S.V. and Parvin, R. J. Biol. Chem. 251:6683–6691, 1975.Google Scholar
  53. 53.
    Wolkowicz, P.E., Pownall, H.J. and McMillin-Wood, J.B. Biochemistry 21:2990–2996, 1982.PubMedCrossRefGoogle Scholar
  54. 54.
    McGarry, J.D. and Foster, D.W. Diabetes 23:485–493, 1974.PubMedGoogle Scholar
  55. 55.
    May, M.E., Aftring, R.P. and Buse, M.G. J. Biol. Chem. 255:8394–8397, 1980.Google Scholar
  56. 56.
    Olowe, Y. and Shulz, H. J. Biol. Chem. 256:5408–5413, 1982.Google Scholar
  57. 57.
    Cuebas, D., Sabbagh, B. and Schultz, H. Fed. Proc. 42:1855, 1983.Google Scholar
  58. 58.
    Didier, J.P., Moreau, D. and Opie, L.H. J. Mol. Cell. Cardiol. 12 1191–1206, 1980.CrossRefGoogle Scholar
  59. 59.
    Higgins, T.J., Allsopp, D., Bailey, P.J. and D’Souza, E.D. J. Mol. Cell. Cardiol. 13:599–615, 1981.CrossRefGoogle Scholar
  60. 60.
    Dalby, A.J., Bricknell, O.L. and Opie, L.H. Cardiovasc. Res. 15:588–598, 1981.PubMedCrossRefGoogle Scholar
  61. 61.
    Liedtke, A.J., Nellis, S.H. and Whitesell, L.F. J. Mol. Cell. Cardiol. 14:195–205, 1981.CrossRefGoogle Scholar
  62. 62.
    Bricknell, O.L., Daries, P.S. and Opie, L.H. J. Mol. Cell. Cardiol. 13:941–946, 1981.CrossRefGoogle Scholar
  63. 63.
    Apstein, C.S., Gravino, F.N. and Haudenschild, C.C. Circ. Res. 52:515–526, 1983.PubMedGoogle Scholar
  64. 64.
    Doorey, A.J. and Barry, W.H. Circ. Res. 53:192–201, 1983.PubMedGoogle Scholar
  65. 65.
    Rogers, W.J., Stanley, A.W., Breinig, J.B., Prather, J.W., McDaniel, H.G., Moraski, R.E., Mantle, J.A., Russell, R.O., Jr. and Rackley, C.E. Am. Heart J. 92:441–454, 1976.PubMedCrossRefGoogle Scholar
  66. 66.
    Rackley, C.E., Russell, R.O., Jr., Rogers, W.J., Mantle, J.A., McDaniel, H.G. and Papapietro, S.E. Am. Heart J. 102:1038–1049, 1981.PubMedCrossRefGoogle Scholar
  67. 67.
    Rackley, C.E., Russell, R.O., Jr., Rogers, W.J., Mantle, J.A., McDaniel, H.G. and Papapietro, S.E. Annu. Rev. Med. 33:375–383, 1982.PubMedCrossRefGoogle Scholar
  68. 68.
    Sodi-Pallares, D. Arch. Inst. Cardiol. Mex 31:557–574, 1981.Google Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1985

Authors and Affiliations

  • A. J. Liedtke
    • 1
  • J. E. Orie
    • 1
  • E. J. Toggart
    • 1
  1. 1.Cardiology Section, Center for Health SciencesUniversity of Wisconsin, MadisonMadisonUSA

Personalised recommendations