Pathogenesis of Preeclampsia

  • Gina Gregorini
  • Norberto Perico
  • Giuseppe Remuzzi
Part of the Topics in Renal Medicine book series (TIRM, volume 1)


Preeclampsia commonly occurs in primiparas [1], the usual clinical manifestations being hypertension, proteinuria, and edema. Even after a severe preeclampsia in the first pregnancy, however, these women may have no more trouble in subsequent pregnancies [2], Preeclampsia, in fact, is rare in multiparas unless there are some predisposing factors, such as conditions associated with increased placental mass (hydatiform mole, Rh incompatibility, twin pregnancies) or previous maternal vascular diseases, such as essential hypertension, hypertensive nephropathies, or autoimmune disorders with vascular damage (scleroderma, systemic lupus erythematosus). Placental tissue, but not fetus, is required for development of preeclampsia, as in pregnancy complicated by hydatiform mole.


Obstet Gynecol Plasma Renin Activity Normal Pregnancy Renin Release Severe Preeclampsia 
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Copyright information

© Martinus Nijhoff Publishing 1986

Authors and Affiliations

  • Gina Gregorini
  • Norberto Perico
  • Giuseppe Remuzzi

There are no affiliations available

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