Monoclonal Antibodies in the Study of Cell Lineage, Differentiation and Malignancy in the Human Breast

  • J. Taylor-Papadimitriou
  • J. Bartek
  • E. Durban
  • J. Burchell
  • R. C. Hallowes
  • E. B. Lane
  • R. Millis
Part of the Developments in Oncology book series (DION, volume 35)

Abstract

Monoclonal antibodies directed to cytokeratins, to surface mucins and to components exported by epithelial cells have been used to study cell lineages and differentiation phenotypes in the human mammary gland. These antibodies have been used to evaluate the suitability of in vitro culture systems for studying differentiation and to identify possible target cells in breast cancer. The practical application of the antibodies in cancer diagnosis and in the killing of tumour cells is discussed.

Keywords

Acetone Carbohydrate Lymphoma Lactate Leukemia 

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Copyright information

© Martinus Nijhoff Publishing, Boston 1985

Authors and Affiliations

  • J. Taylor-Papadimitriou
    • 1
  • J. Bartek
    • 2
  • E. Durban
    • 3
  • J. Burchell
    • 1
  • R. C. Hallowes
    • 1
  • E. B. Lane
    • 1
  • R. Millis
    • 1
  1. 1.Imperial Cancer Research FundLondonUK
  2. 2.Res. Institute of Clin. & Exp. OncologyBrnoCzechoslovakia
  3. 3.Baylor College of Med.HoustonUSA

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