Abstract
H59 recognizes an estrogen regulated cell surface peptide or two peptides of approximately 30K daltons. The lines of evidence suppporting its estrogen regulation are both direct from in vitro systems and indirect from tissue specimens. H59 antibody binds only to hormone dependent human breast cancer cell lines. In addition, it does not bind to R27 and R3 two tamoxifen resistant and estrogen independent cell lines derived from estrogen dependent MCF-7 cells. The H59 antibody detects an antigen which is increased in estrogen stimulated cells and decreased in tamoxifen inhibited cells. The antigen appears to be estrogen regulated in human breast colostrum and milk as well. The monoclonal antibodies which we have generated have been reacted with more than 300 specimens of breast cancer and more than 100 specimens of benign disease. The H59 antibody binds only to a subset of specimens that are estrogen and/or progesterone receptor positive and to most benign disease. Our data suggests that the presence of H59 and other differentiation antibodies correlates only with estrogen and progesterone receptor and not with other factors associated with a favorable prognosis.
Supported in part by NIH grant CA 32895.
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Hendler, F., Kingsley, W., Burns, D., House, D., Patrick, K., Yuan, D. (1985). Clinical Studies on Cell Surface Estrogen-Regulated Proteins. In: Ceriani, R.L. (eds) Monoclonal Antibodies and Breast Cancer. Developments in Oncology, vol 35. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2617-5_2
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