Monoclonal Antibodies Against Estrogen Receptor: Specificity, Sensitivity and Potential Applications

  • K. McCartyJr.
  • J. Snowhite
  • E. Cox
  • L. Miller
  • K. McCartySr.
Part of the Developments in Oncology book series (DION, volume 35)


A study of immunohistochemical localization of estrogen receptor in one hundred and thirty-four human breast cancers and twenty-three metastatic lesions shows sensitivities and specificities of 91% as compared to biochemical analyses. A close correlation between the categorization of tumors by both methods is demonstrated. The immunohistochemical assay is shown to be sensitive and specific at threshold values of receptor. A comparison to clinical response for an initial cohort of twenty-three patients shows excellent predictive value for the immunohistochemical method.


Biochemical Assay Control Slide Invasive Component Receptor Content Estrogen Binding 
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Copyright information

© Martinus Nijhoff Publishing, Boston 1985

Authors and Affiliations

  • K. McCartyJr.
    • 1
  • J. Snowhite
    • 1
  • E. Cox
    • 1
  • L. Miller
    • 1
  • K. McCartySr.
    • 1
  1. 1.Duke UniversityDurhamUSA

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