Skip to main content
SpringerLink
Log in
Book cover

Monoclonal Antibodies and Breast Cancer pp 165–178Cite as

Intracellular and Extracellular Keratins of Human Mammary Epithelial Cells

  • Chapter

Part of the book series: Developments in Oncology ((DION,volume 35))

Abstract

Intermediate filaments are a major component of the cytoskeleton in many types of cells. Monoclonal antibodies against intermediate filament proteins have proven to be very useful reagents in the specific identification of various types of cells, and consequently, have found major use in the histochemical characterization of tumors (1,2,3). Epithelial cells, such as those in the mammary gland, contain intermediate filaments composed of keratin. These proteins, which are found in both normal and neoplastic mammary cells, have been the subject of intense research during the past several years (4,5).

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Schlegel, R., Banks-Schlegel, S., McLeod, J.A. and Pinkus, G.S. Am. J. Pathol. 101: 41–49, 1980.

    PubMed  CAS  Google Scholar 

  2. Gabbiani, G., Kapanci, Y., Barrazone, P., and Franke, W.W. Am. J. Pathol. 104: 206–216, 1981.

    PubMed  CAS  Google Scholar 

  3. Ramaekers, F.C.S., Puts, J.J.G., Kant, A., Moesker, O., Jap, P.H.K. and Vooijs, G.P. Cold Spring Harbor Symp. Quant. Biol. 46: 331–339, 1981.

    Google Scholar 

  4. Krepler, R., Denk, H., Weirich, E., Schmid, E. and Franke, W.W. Differentiation 20: 242–252, 1981.

    Article  PubMed  CAS  Google Scholar 

  5. Altmannsberger, M., Osborn, M., Holscher, A., Schauer, A. and Weber, K. Virchows Arch. 37: 277–284, 1981.

    Article  CAS  Google Scholar 

  6. Fuchs, E. and Marchuk, D. Proc. Natl. Acad. Sci. U.S.A. 80: 5857–5861, 1983.

    Article  PubMed  CAS  Google Scholar 

  7. Moll, R., Franke, W.W., Schiller, D.L., Geiger, B. and Krepler, R. Cell 31: 11–24, 1982.

    Article  PubMed  CAS  Google Scholar 

  8. Sun, T-T., Eichner, R., Schermer, A., Cooper, D., Nelson, W.G. and Weiss, R.A. In: Cancer Cells 1, The Transformed Phenotype (Eds. A. Levine, W. Topp, G. Van de Woude and J.D. Watson ), Cold Spring Harbor Laboratory, New York, 1984, pp. 169–176.

    Google Scholar 

  9. Moll, R., Krepler, R. and Franke, W.W. Differentiation 23: 256–269, 1983.

    Article  PubMed  CAS  Google Scholar 

  10. Allen, R., Dulbecco, R., Syka, P., Bowman, M. and Armstrong, B. Proc. Natl. Acad. Sci. U.S.A. 81: 1203–1207, 1984.

    Article  PubMed  CAS  Google Scholar 

  11. Soule, H.D., Vazquez, J., Long, A., Albert, S. and Brennan, M. JNCI 51: 1409–1416, 1973.

    PubMed  CAS  Google Scholar 

  12. Sun, T-T. and Green, H. J. Biol. Chem. 263: 2053–2060, 1978.

    Google Scholar 

  13. Gown, A.M. and Vogel, A.M. J. Cell Biol. 95: 414–424, 1982.

    Article  PubMed  CAS  Google Scholar 

  14. Tseng, S.C.G., Jarvinen, M.J., Nelson, W.G., Huang, J-W., Woodcock-Mitchell, J., and Sun, T-T. Cell 30: 361–372, 1982.

    Article  PubMed  CAS  Google Scholar 

  15. Knapp, L.W., O’Guin, W.M. and Sawyer, R.H. Science 219: 501–503, 1983.

    Article  PubMed  CAS  Google Scholar 

  16. Wang, E. and Choppin, P.W. Proc. Natl. Acad. Sci. U.S.A. 78: 2363–2367, 1981.

    Article  PubMed  CAS  Google Scholar 

  17. Horowitz, B., Kupfer, H., Eshhar, Z. and Geiger, B. Exp. Cell Res. 134: 281–290, 1981.

    Article  Google Scholar 

  18. Eckert, B.S., Caputi, S.E. and Warren, R.H. Cell Motility 4: 169–181, 1984.

    Article  PubMed  CAS  Google Scholar 

  19. Eckert, B.S., Daley, R.A. and Parysek, L.M., Cold Spring Harbor Symp. Quant. Biol. 46: 403–412, 1982.

    Google Scholar 

  20. Dulbecco, R., Unger, M., Armstrong, B., Bowman, M. and Syka, P. Proc. Natl. Acad. Sci. U.S.A. 80: 1033–1037, 1983.

    Article  PubMed  CAS  Google Scholar 

  21. Brabon, A.C., Williams, J.F. and Cardiff, R.D. Cancer Res. 44: 2704–2710, 1984.

    PubMed  CAS  Google Scholar 

  22. Franke, W.W., Moll, R.,. Mueller, H., Schmid, E., Kuhn, C., Krepler, R., Artlieb, U. and Denk, H. Proc. Natl. Acad. Sci. U.S.A. 80: 543–547, 1983.

    Article  PubMed  CAS  Google Scholar 

  23. Keydar, I., Chen, L., Karby, S., Weiss, F.R., Delarea, J., Radu, M., Chaitcik, S. and Brenner, H.J. Eur. J. Cancer 15: 659–670, 1979.

    CAS  Google Scholar 

  24. Fogh, J. and Trempe, G. In: Human Tumor Cells In Vitro (Ed. J. Fogh), Plenum Press, New York, 1975 pp. 115–159.

    Google Scholar 

  25. Hanukoglu, I. and Fuchs, E. Cell 33: 915–924, 1983.

    Article  PubMed  CAS  Google Scholar 

  26. Westley, B. and Rochefort, H.A., Cell 20: 353–362, 1980.

    Article  PubMed  CAS  Google Scholar 

  27. Poutsiaka, D.D. and Black, P.H. GANN Monograph on Cancer Res. 29: 47–57, 1983.

    Google Scholar 

  28. Mairesse, N., Devleeschovwer, N., Leclercq, G. and Galand, P. J. Steroid Biochem. 15: 375–381, 1981.

    Article  PubMed  CAS  Google Scholar 

  29. Luning, B., Wiklund, B., Redelius, P. and Bjorklund, B. Biochim. Biophys. Acta 624: 90–101, 1980.

    PubMed  CAS  Google Scholar 

  30. Luning, B. and Nilsson, U. Acta Chemica Scand. B 37: 731–653, 1983.

    Article  CAS  Google Scholar 

  31. Madri, J.A. and Barwick, K.W. Lab Invest. 48: 98–107, 1983.

    PubMed  CAS  Google Scholar 

  32. Toh, B.H., Yildiz, A., Sotelo, J., Osung, O., Holborow, E.J., Kanakoudi, F. and Small, J.V. Clin. Exp. Immunol. 37: 76–82, 1979.

    PubMed  CAS  Google Scholar 

  33. Linder, E., Kurki, P. and Andersson, L.C. Clin. Immunol. and Immunopathol. 14: 411–417, 1979.

    Article  CAS  Google Scholar 

  34. Pedersen, J.S., Toh, B.H., Locarnini, S.A., Gust, I.D. and Shyamala, G.N.S. Clin. Immunol. and Immunopathol. 21: 154–161, 1981.

    Article  CAS  Google Scholar 

  35. Kurki, P., Virtanen, I., Lehto, V-P., Alfthan, O. and Salaspuro, M. Alcoholism: Clin. and Exp. Res. 8: 212-215, 1984.

    Article  CAS  Google Scholar 

  36. Kurki, P., Helve, T. and Virtanen, I. J. Rheumatol. 10: 558–562, 1983.

    PubMed  CAS  Google Scholar 

  37. Duncan, R. and Hershey, J.W.B. Analytical Biochem. 138: 144–155, 1984.

    Article  CAS  Google Scholar 

  38. O’Farrell, P. J. Biol. Chem. 250: 4007–4021, 1975.

    Google Scholar 

  39. Towbin, H., Straehelin, T. and Gordon, J. Proc. Natl. Acad. Sci. U.S.A. 76: 4350–4354, 1979.

    Article  PubMed  CAS  Google Scholar 

  40. Hawkes, R., Niday, E. and Gordon, J. Analytical Biochem. 119: 142–147, 1982.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, School of Medicine, University of California, Davis, California, 95616, USA

    R. Chan, P. V. Rossitto, B. F. Edwards & R. D. Cardiff

Authors
  1. R. Chan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. V. Rossitto
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. B. F. Edwards
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. D. Cardiff
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. John Muir Cancer and Aging Research Insitute, Walnut Creek, California, USA

    Roberto L. Ceriani

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Martinus Nijhoff Publishing, Boston

About this chapter

Cite this chapter

Chan, R., Rossitto, P.V., Edwards, B.F., Cardiff, R.D. (1985). Intracellular and Extracellular Keratins of Human Mammary Epithelial Cells. In: Ceriani, R.L. (eds) Monoclonal Antibodies and Breast Cancer. Developments in Oncology, vol 35. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2617-5_12

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2617-5_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9637-9

  • Online ISBN: 978-1-4613-2617-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation