Immunohistochemistry of Ovarian Tumors

  • Robert E. Scully
Part of the Developments in Oncology book series (DION, volume 34)

Zusammenfassung

Almost all ovarian tumors can be diagnosed on routine examination of adequate numbers of sections stained with hematoxylin and eosin, with the occasional addition of mucin, glycogen, argyrophil or reticulum stains (1). Although electron microscopic studies have expanded our knowledge of the morphologic features of ovarian tumors, they have rarely yielded information of diagnostic significance. Immunohistochemistry has already contributed to our understanding of the biology of ovarian tumors, but up to the present time has likewise been of little diagnostic aid. It is probable, however, that, with the continuing identification of new and more specific antibodies and experience with larger numbers of cases, this approach will have on increasingly important role in the diagnosis of unusual ovarian tumors.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Scully RE: Tumors of the ovary and maldeveloped gonads. Atlas of Tumor Pathology, Second series-Fascicle 6. Armed Forces Institute of Pathology, Washington, 1979, pp. 413.Google Scholar
  2. 2.
    Erlandson RA: Diagnostic immunohistochemistry of human tumors. Am J Surg Pathol (8):615–624, 1984.PubMedGoogle Scholar
  3. 3.
    Serov S, Scully RE, Sobin LH: Histological typing of ovarian tumours. International histological classification of tumours, no. 9. World Health Organization, Geneva, 1973. 56 pp.Google Scholar
  4. 4.
    Kurman RJ, Ganjei P, Nadji M: Contributions of immunocytochemistry to the diagnosis and study of ovarian neoplasms. Int J Gynecol Pathol (3):3–26, 1984.PubMedGoogle Scholar
  5. 5.
    Fenoglio CM: Antigens, enzymes and hormones. Their roles as tumor markers in gynecologic neoplasia. Diagn Gynecol Obstet (2):33–42, 1980.PubMedGoogle Scholar
  6. 6.
    Crum CP, Fenoglio CM: The immunoperoxidase technique. Review of its application to diseases of the female genital tract. Diagn Gynecol Obstet (2):103–115, 1980.PubMedGoogle Scholar
  7. 7.
    Kurman RJ: Contributions of immunocytochemistry to gynaecological pathology. Clin Obstet Gynaecol (11):5–23, 1984.PubMedGoogle Scholar
  8. 8.
    van Nagell JR, Donaldson ES, Hanson MB, Gay EC, Pavlik EJ: Biochemical markers in the plasma and tumors of patients with gynecologic malignancies. Cancer (48):495–503, 1981.PubMedGoogle Scholar
  9. 9.
    Marchand A, Fenoglio CM, Pascal R, Richart RM, Bennett S: Carcinoembryonic antigen in human ovarian neoplasms. Cancer Res (35):3807–3810, 1975.PubMedGoogle Scholar
  10. 10.
    Seppala M, Pihko H, Rouslahti E: Carcinoembryonic antigen and alpha fetoprotein in malignant tumors of the female genital tract. Cancer (35):1377–1381, 1975.PubMedGoogle Scholar
  11. 11.
    Heald J, Buckley CH, Fox H: An immunohistochemical study of the distribution of carcinoembryonic antigen in epithelial tumors of the ovary. J Clin Pathol (32):918–926, 1979.PubMedGoogle Scholar
  12. 12.
    Fenoglio CM, Crum CP, Pascal RR, Richart RM: Carcinoembryonic antigen in gynecologic patients. II. Immunohistological expression, Diagn Gynecol Obstet (3):291–299, 1981.PubMedGoogle Scholar
  13. 13.
    Charpin C, Bhan AK, Zurawski VR Jr, Scully RE: Carcinoembryonic antigen (CEA) and carbohydrate determinant 19–9 (CA19–9) localization in 121 primary and metastatic ovarian tumors: an immunohistochemical study with the use of monoclonal antibodies. Int J Gynecol Pathol (1):231–245, 1982.PubMedGoogle Scholar
  14. 14.
    Casper S, van Nagell JR, Powell DF, Dubilier LD, Donaldson ES, Hanson MB, Pavlik EJ: Immunohistochemical localization of tumor markers in epithelial ovarian cancer. Am J Obstet Gynecol (149):154–158, 1984.PubMedGoogle Scholar
  15. 15.
    DeBoer WGRM, Nayman J: Intestine-associated antigens in ovarian tumours: an immunohistological study. Pathol (13):547–555, 1981.Google Scholar
  16. 16.
    Ueda G, Tanaka Y, Hiramatsu K, Inoue Y, Yamasaki M, Inoue M, Kurachi K, Mori T: Immunohistochemical study of mucous antigens in gynecologic tumors with special reference to argyrophil cells. Int J Gynecol Pathol (1):41–45, 1982.PubMedGoogle Scholar
  17. 17.
    Aguirre P, Scully RE, Dayal Y, DeLellis RA: Mucinous tumors of the ovary with argyrophil cells. An immunohistochemical analysis. Am J Surg Pathol (8):345–356, 1984.PubMedGoogle Scholar
  18. 18.
    Fenoglio CM, Hayata T, Crum CP, Richart RM: The expression of human chorionic gonadotrophin in the female genital tract* Localization by the immunoperoxidase technique. Diagn Gynecol Obstet (4):94–97, 1982.Google Scholar
  19. 19.
    Mohabeer J, Buckley CH, Fox H: An immunohistochemical study of the incidence and significance of human chorionic gonadotrophin synthesis by epithelial ovarian neoplasms. Gynecol Oncol (16):78–84, 1983.PubMedGoogle Scholar
  20. 20.
    Muggia FM, Rosen SW, Weintraub BD, Hansen HH: Ectopic placental proteins in nontrophoblastic tumors. Cancer(36):1327–1337, 1975.PubMedGoogle Scholar
  21. 21.
    Nathanson L, Fishman WH: New observations on the Regan isoenzyme of alkaline phosphatase in cancer patients. Cancer (27):1388–1397, 1970.Google Scholar
  22. 22.
    Kellen JA, Bush RS, Malkin A: Placenta-like alkaline phosphatase in gynecological cancers. Cancer Res (36):269–271, 1976.PubMedGoogle Scholar
  23. 23.
    Uchida T, Shikata T, lino S: Immunohistochemical localization of placental and intestinal alkaline phosphatases. In: DeLellis RA (ed) Advances in Immunohistochemistry, Masson Publishing, USA, New York, pp. 185–199.Google Scholar
  24. 24.
    Loose JH, Damjanov I, Harris H: Identity of the neoplastic alkaline phosphatase as revealed with monoclonal antibodies to the placental form of the enzyme. Am J Clin Pathol (82) :173–177, 1984.PubMedGoogle Scholar
  25. 25.
    Takeda A, Matsuyama M, Kuzuya K, Chihara T, Tsubouchi S, Takeuchi S: Mixed mesodermal tumor of the ovary with carcinoembryonic antigen and alkaline phosphatase production. Cancer (53):103–112, 1974.Google Scholar
  26. 26.
    Tsung SH: Localization of °\ -fetoprotein synthesis in malignancies other than hepatoma. Arch Pathol Lab Med (101) : 572–574, 1977.PubMedGoogle Scholar
  27. 27.
    Yasunami R, Hashimoto Z, Ogura T, Hirao F, Yamamura Y: Primary lung cancer producing alpha-fetoprotein: A case report. Cancer (47):926–929, 1981.PubMedGoogle Scholar
  28. 28.
    Higuchi Y, Kouno T, Teshima H, Akizuki S, Kikuta M, Ohyumi M, Yamamoto S: Serous papillary cystadenocarcinoma associated withos. -fetoprotein production. Arch Pathol Lab Med (108).710–712, 1984.PubMedGoogle Scholar
  29. 29.
    Dictor M: Ovarian malignant mixed mesodermal tumor: The occurrence of hyaline droplets containingo α-1 antitrypsin. Hum Pathol (13):930–933, 1982.PubMedGoogle Scholar
  30. 30.
    Silva FG, Taylor WE, Burns DK: Demonstration of alpha-1-antitrypsin in yet another neoplasm. Hum Pathol (15):494, 1984.PubMedGoogle Scholar
  31. 31.
    van Kley H, Cramer S, Bruns DE: Serous ovarian neoplastic amylase (SONA): a potential useful marker for serous ovarian tumors. Cancer (48):1444–1449, 1981.PubMedGoogle Scholar
  32. 32.
    Hayakawa T, Kameya A, Mizuno R, Noda A, Kondo T, Hirabayashi N: Hyperamylasemia with papillary serous cystadenocarcinoma of the ovary. Cancer (54):1662–1665, 1984.PubMedGoogle Scholar
  33. 33.
    Bruns DE, Mills SE, Savory J: Amylase in fallopian tube and serous ovarian neoplasms. Immunohistochemical localization. Arch Pathol Lab Med (106):617–620, 1982.Google Scholar
  34. 34.
    Sporrong B, Alumets J, Clase L, Falkmer S, Hakanson R, Ljungberg 0, Sundler F: Neurohormonal peptide immunoreactive cells in mucinous cystadenomas and cystadenocarcinomas of the ovary. Virchows Arch (Pathol Anat) (392):271–280, 1981.Google Scholar
  35. 35.
    Takeda A, Matsuyama M, Chihara T, Suchi T, Sato T, Tomoda Y: Ultrastructure and immunocytochemistry of gastroentero-pancreatic (GEP) endocrine cells in mucinous tumors of the ovary. Acta Pathol Jpn (32):1003–1015, 1982.PubMedGoogle Scholar
  36. 36.
    Louwerens JK, Schaberg A, Bosman FT: Neuroendocrine cells in cystic mucinous tumors of the ovary. Histopathology (7):389–398, 1983.PubMedGoogle Scholar
  37. 37.
    Scully RE, Aguirre P, DeLellis RA: Argyrophilia, serotonin, and peptide hormones in the female genital tract and its tumors. Int J Gynecol Pathol (3):51–70, 1984.PubMedGoogle Scholar
  38. 38.
    Ueda G, Yamasaki M, Inoue M, Tanaka Y, Hiramatsu K, Inoue Y, Saito J, Nishino T, Kurachi K: Argyrophil cells in the endometrioid carcinoma of the ovary. Cancer (54):1569–1573, 1984.PubMedGoogle Scholar
  39. 39.
    Cocco AE, Conway S: Zollinger-Ellison syndrome associated with ovarian mucinous cystadenocarcinoma. N Engl J Med (293):485–486, 1975.PubMedGoogle Scholar
  40. 40.
    Long TT, Barton TK, Draff in R, Reeves WJ, McCarty KS: Conservative management of the Zollinger-Ellison syndrome. Ectopic gastrin production by an ovarian cystadenoma. JAMA (243) :1837–1839, 1980.PubMedGoogle Scholar
  41. 41.
    Miettinen M, Lehto VP, Virtanen I: Expression of intermediate filaments in normal ovaries and ovarian epithelial, sex cord-stromal, and germinal tumors. Int J Gynecol Pathol (2):64–71, 1983.PubMedGoogle Scholar
  42. 42.
    del Poggetto CB, Virtanen I, Lehto VP, Wahlstrom T, Saksela E: Expression of intermediate filaments in ovarian and uterine tumors. Int J Gynecol Pathol (1):359–366, 1983.Google Scholar
  43. 43.
    Ramaekers F, Huysmans A, Moesker O, Kant A, Jap P, Herman C, Vooijs P: Monoclonal antibody to keratin filaments, specific for glandular epithelia and their tumors. Lab Invest (49).353–361, 1983.PubMedGoogle Scholar
  44. 44.
    Nagle RB, Clark VA, McDaniel KM, Davis JR: Immunohistochemical demonstration of keratins in human ovarian neoplasms. A comparison of methods. J Histochem Cytochem (31) :1010–1014, 1983.PubMedGoogle Scholar
  45. 45.
    Davis BW, Morassi LL, Locher GW, Wetherall N, Grigolato P: Cellular localization of keratin in proliferative epithelial processes and neoplasms of the human ovary. J Cancer Res Clin Oncol (106): 222–228, 1983.PubMedGoogle Scholar
  46. 46.
    Moll R, Levy R, Czernobilsky B, Hohlweg-Majert P, Dallenbach-Hellweg G, Franke WW: Cytokeratins of normal epithelia and some neoplasms of the female genital tract. Lab Invest (49):599–610, 1983.PubMedGoogle Scholar
  47. 47.
    Gown AM, Gabbiani G: Intermediate-sized (10-nm) filaments in human tumors. In: DeLellis RA, ed. Diagnostic immunochemistry. Masson Publishing, USA, New York, 1981, pp. 89–109. (Masson monographs in diagnostic pathology)•Google Scholar
  48. 48.
    Ganjei P, Nadji M, Penneys NS, Averette HE, Morales AR: Immunoreactive prekeratin in Brenner tumors of the ovary. Int J Gynecol Pathol (l):353–358, 1983.Google Scholar
  49. 49.
    Ramaekers FCS, Verheijen RHM, Moesker 0, Kant A, Vooijs GP, Herman CJ: Mesodermal mixed tumor. Diagnosis by analysis of intermediate filament proteins. Am J Surg Pathol (7):381–385, 1983.PubMedGoogle Scholar
  50. 50.
    Rice RH, Pinkus GS, Warhol MJ, Antonioli DA: Involvier in: Biochemistry and immunohistochemistry. In: DeLellis RA, ed. Diagnostic immunocytochemistry. Masson Publishing, USA, New York, 1981, pp. 111–125. (Masson monographs in diagnostic pathology).Google Scholar
  51. 51.
    Said JW, Nash G, Sassoon AF, Shintaku IP, Banks-Schlegal S: Involucrin in lung tumors. A specific marker for squamous differentiation. Lab Invest (49):563–568, 1983.PubMedGoogle Scholar
  52. 52.
    Warhol MJ, Rice RH, Pinkus GS, Robboy SJ: Evaluation of squamous epithelium in adenocanthoma and adenosquamous carcinoma of the endometrium: immunoperoxidase, analysis of involucrin and keratin localization. Int J Gynecol Pathol (3):82–91, 1984.PubMedGoogle Scholar
  53. 53.
    Mukai K, Rosai J: Application of immunoperoxidase techniques in surgical pathology. In Progress in surgical pathology, Vol 1, CM Fenoglio and M. Wolff, Eds. Masson, New York, 1980, pp. 15–49.Google Scholar
  54. 54.
    Bussolati G, Gugliotta P, Fulcheri E: Iramunohistochemistry of act in in normal and neoplastic tissues. Diagnostic immunocytochemistry In: DeLellis RA, ed. Masson Publishing, USA, New York, 1981, pp. 325–342. (Masson monographs in diagnostic pathology).Google Scholar
  55. 55.
    deJong ASH, van Vark M, Albus-Lutter Ch E, van Raamsdonk W, Voute PA: Myosin and myoglobin as tumor markers in the diagnosis of rhabdomyosarcoma. Am J Surg Pathol (8): 521–528, 1984.PubMedGoogle Scholar
  56. 56.
    Mukai K, Varela-Duran J, Nochomovitz LE: The rhabdomyoblast in mixed mullerian tumors of the uterus and ovary: an immunohistochemical study of myoglobin in 25 cases. Am J Clin Pathol (74) :101–104, 1980.PubMedGoogle Scholar
  57. 57.
    Brooks JJ: Immunohistochemistry of myoglobin. In: DeLellis RA, ed. Diagnostic immunocytochemistry. Masson Publishing, USA, New York, 1981, pp. 343–358. (Masson monographs in diagnostic pathology).Google Scholar
  58. 58.
    Bhattacharya M, Chatterjee SK, Barlow JJ, Fuji H: Monoclonal antibodies recognizing tumor-associated antigen of human ovarian mucinous cystadenocarcinomas. Cancer Res (42):1650–1654, 1982.PubMedGoogle Scholar
  59. 59.
    Kabawat SE, Bast RC Jr. Bhan AK, Welch WR, Knapp RC, Colvin RB: Tissue distribution of a coelomic-epithelium-related antigen recognized by the monoclonal antibody 0C125. Int J Gynecol Pathol (2):275–285, 1983.PubMedGoogle Scholar
  60. 60.
    Kabawat SE, Bast RC, Welch WR, Knapp RC, Colvin RB: Immunopathologic characterization of a monoclonal antibody that recognizes common surface antigens of human ovarian tumors of serous, endometrioid, and clear cell types. Am J Clin Pathol (79):98–104, 1983.PubMedGoogle Scholar
  61. 61.
    Rilke F: Carcinoma of the breast and ovary as a model for the application of monoclonal antibodies to diagnostic pathology. Presented at XV International Congress of Int Acad Pathol, Miami Beach, Fla, 1984.Google Scholar
  62. 62.
    Mattes MJ, Cordon-Cardo C, Lewis JL Jr, Old LJ, Lloyd KO: Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies. Proc Natl Acad Sci USA (81) :568–572, 1984.PubMedGoogle Scholar
  63. 63.
    Mariani-Costantini R, Colnaghi MI, Leoni F, Menard S, Cerasoli S, Rilke F: Immunohistochemical reactivity of a monoclonal antibody prepared against human breast carcinoma. Virch Arch (Pathol Anat) (402):389–404, 1984.Google Scholar
  64. 64.
    Press MF, Greene GL: Methods in laboratory investigation. An immunocytochemical method of demonstrating estrogen receptor in human uterus using monoclonal antibodies to human estrophilin. Lab Invest (50):480–486, 1984.PubMedGoogle Scholar
  65. 65.
    Holt JA, Caputo TA, Kelly KM, Greenwald P, Chorost S: Estrogen and progestin binding in cytosols of ovarian adenocarcinomas. Obstet Gynecol (53):50–58, 1979.PubMedGoogle Scholar
  66. 66.
    Creasman WT, Sasso RA, Weed JC Jr., McCarthy KS Jr.: Ovarian carcinoma: histologic and clinical correlation of cytoplasmic estrogen and progesterone binding. Gynecol Oncol (12):319–327, 1981.PubMedGoogle Scholar
  67. 67.
    Hahnel R, Kelsall GRH, Martin JD, Masters AM, McCartney AJ, Twaddle E: Estrogen and progesterone receptors in tumors of the human ovary. Gynecol Oncol (13):145–151, 1982.PubMedGoogle Scholar
  68. 68.
    Kauppila A, Vierikko P, Kivinen S, Stenback F, Vihko R: Clinical significance of estrogen and progestin receptors in ovarian cancer. Obstet Gynecol (61):320–326, 1983.PubMedGoogle Scholar
  69. 69.
    Liotta L: Biochemical mechanisms of tumor invasion. Presented at XV International Congress of Int Acad Pathol, Miami Beach, Florida, 1984.Google Scholar
  70. 70.
    Haglund C, Roberts PJ, Nordling S, Ekblom P: Expression of laminin in pancreatic neoplasms and in chronic pancreatitis. Am J Surg Pathol (8):669–676, 1984.PubMedGoogle Scholar
  71. 71.
    Gusterson BA, Warburton MJ, Mitchell D, Kraft N, Hancock WW: Invading squamous cell carcinoma can retain a basal lamina. An immunohistochemical study using a monoclonal antibody to type IV collagen. Lab Invest (51):82–87, 1984.PubMedGoogle Scholar
  72. 72.
    Kurman RJ, Scardino PT, McIntire KR, Waldmann TA, Javadpour N, Norris HJ: Malignant germ cell tumors of the ovary and testis. An immunohistologic study of 69 cases. Ann Clin Lab Sci (9):462–466, 1979.PubMedGoogle Scholar
  73. 73.
    Kurman RJ, Scardino PT: Alpha-fetoprotein and human chorionic gonadotropin in ovarian and testicular germ cell tumors. In: DeLellis RA, ed. Diagnostic immunocytochemistry. Masson Publishing, USA, New York, 1981, pp 277–298. (Masson monographs in diagnostic pathology)Google Scholar
  74. 74.
    Kurman RJ, Norris HS: Malignant mixed germ cell tumors of the ovary. A clinical and pathologic analysis of 30 cases. Obstet Gynecol (48):579–589, 1976.PubMedGoogle Scholar
  75. 75.
    Beck JS, Fulmer HF, Lee ST: Solid malignant ovarian teratoma with “embryoid bodies” and trophoblastic differentiation. J Pathol (99):67–73, 1969.PubMedGoogle Scholar
  76. 76.
    Takeda A, Ishizuka T, Goto T, Goto S, Ohta M, Tomoda Y, Hosino M: Polyembryoma of ovary producing alpha-fetoprotein and HCG: immunoperoxidase and electron microscopic study. Cancer (49):1878–1889, 1982.PubMedGoogle Scholar
  77. 77.
    Kurman RJ, Norris HJ: Embryonal carcinoma of the ovary. A clinicopathological entity distinct from endodermal sinus tumor resembling embryonal carcinoma of the adult testis. Cancer (38):2420–2433, 1976.PubMedGoogle Scholar
  78. 78.
    Zaloudek CJ, Tavassoli FA, Norris HJ: Dysgerminoma with syncytiotrophobla8tic giant cells. A histologically and clinically distinctive subtype of dysgerminoma. Ara J Surg Pathol (5):361–367, 1981.Google Scholar
  79. 79.
    Case Records of the Massachusetts General Hospital. Case 11. N Engl J Med (286):594–600, 1972.Google Scholar
  80. 80.
    Home CHW, Rankin R, Bremmer RD: Pregnancy-specific proteins as markers for gestational trophoblastic disease. Int J Gynecol Pathol (3):27–40, 1984.Google Scholar
  81. 81.
    Kurraan RJ, Norris HJ: Endodermal sinus tumor of the ovary. A clinical and pathologic analysis of 71 cases. Cancer (38) :2404–2419, 1976.Google Scholar
  82. 82.
    Prat J, Bhan AK, Dickersin GR, Robboy SJ, Scully RE: Hepatoid yolk sac tumor of the ovary (Endodermal sinus tumor with hepatoid differentiation). A light microscopic, ultrastructural and immunohistochemical study of seven cases. Cancer (50):2355–2368, 1982.PubMedGoogle Scholar
  83. 83.
    Scully RE: Personal observation.Google Scholar
  84. 84.
    Palmer PE, Safaii H, Wolfe HJ: Alpha1-antitrypsin and alpha-fetoprotein. Protein markers in endodermal sinus (yolk sac) tumors. Am J Clin Pathol (65) : 575–582, 1976.PubMedGoogle Scholar
  85. 85.
    Aguirre P, Scully RE, DeLellis RA: Unpublished data.Google Scholar
  86. 86.
    Battifora H, Sheibani K, Tubbs RR, Kopinski MI, Sun T-T: Antikeratin antibodies in tumor diagnosis. Distinction between seminoma and embryonal carcinoma. Cancer (54) : 843–848, 1984.PubMedGoogle Scholar
  87. 87.
    Bosman FT, Louwerens JWK: APUD cells in teratomas. Am J Pathol (104):174–180, 1981.PubMedGoogle Scholar
  88. 88.
    Calame J, Bosman FT, Schaberg A, Louwerens JWK: Immunocytochemical localization of neuroendocrine hormones and oncofetal antigens in ovarian teratomas. Int J Gynecol Pathol (3):92–100, 1984.PubMedGoogle Scholar
  89. 89.
    Robboy SJ, Norris HJ, Scully RE: Insular carcinoid primary in the ovary. A clinicopathologic analysis of 48 cases. Cancer (36):404–418, 1975.PubMedGoogle Scholar
  90. 90.
    Robboy SJ, Scully RE, Norris HS: Primary trabecular carcinoid of the ovary. Obstet Gynecol (49):202–207, 1977.PubMedGoogle Scholar
  91. 91.
    Sporrong B, Falkmer S, Robboy SJ, Alumets J, Hakanson R, Ljungberg O, Sundler F: Neurohormonal peptides in ovarian carcinoids: an immunohistochemical study of 81 primary carcinoids and of intraovarian metastases from six mid-gut carcinoids. Cancer (49):68–74, 1982.PubMedGoogle Scholar
  92. 92.
    Robboy SJ, Scully RE: Strumal carcinoid of the ovary. An analysis of 50 cases of a distinctive tumor composed of thyroid tissue and carcinoid. Cancer (46):2019–2034, 1980.PubMedGoogle Scholar
  93. 93.
    Ueda G, Sato Y, Yamasaki M, Inoue M, Hiramatsu K, Kurachi K, Amino N, Miyai K: Strumal carcinoid of the ovary. Histological, ultrastructural, and immunohistological studies with anti-human thyroglobulin. Gynecol Oncol (6):411–419, 1978.PubMedGoogle Scholar
  94. 94.
    Greco MA, LiVolsi VA, Pertschuk LP, Bigelow B: Strumal carcinoid of the ovary. An analysis of its components. Cancer (43):1380–1383, 1979.PubMedGoogle Scholar
  95. 95.
    Dayal Y, Tashjian AH Jr, Wolfe HJ: Immunocytochemical localization of calcitonin-producing cells in a strumal carcinoid with amyloid stroma. Cancer (43):1331–1338, 1979.PubMedGoogle Scholar
  96. 96.
    Blaustein A: Calcitonin-secreting struma-carcinoid tumor of the ovary. Hum Pathol (10):222–228, 1979.PubMedGoogle Scholar
  97. 97.
    Ulbright TM, Roth LM, Ehrlich CE: Ovarian strumal carcinoid. An immunocytochemical and ultrastructural study of two cases. Am J Clin Pathol (77):622–631, 1982.PubMedGoogle Scholar
  98. 98.
    Senterman MK, Cassidy PN, Fenaglio CM, Ferenczy A: Histology, ultrastructure and immunohistochemistry of strumal carcinoid: a case report. Int J Gynecol Pathol (3):232–240, 1984.PubMedGoogle Scholar
  99. 99.
    Dranoff G, Bigner DD: A word of caution in the use of neuron-specific enolase expression in tumor diagnosis. Arch Pathol Lab Med (108):535, 1984.PubMedGoogle Scholar
  100. 100.
    Vinores SA, Bonnin JM, Rubinstein LS, Marangos PJ: Immunohistochemical demonstration of neuron-specific enolase in neoplasms of the CNS and other tissues. Arch Pathol Lab Med (108):536–540, 1984.PubMedGoogle Scholar
  101. 101.
    O’Connor DT, Burton D, Deftos LH: Immunoreactive human chromogranin A in diverse polypeptide producing human tumors and normal endocrine tissues. J Clin Endocrinol Metab (47):1084–1086, 1983.Google Scholar
  102. 102.
    Kumar NB, Cookingham CL, Lloyd RV, Appelman HD: Detection of human chromogranin with a monoclonal antibody in carcinoid secretory granules and its comparison with the generic silver stains and with serotonin. Lab. Invest. (50):33A, 1984.Google Scholar
  103. 103.
    Akhtar M, Young J, Brody H: Anterior pituitary component in benign cystic ovarian teratomas. Am J Clin Pathol (64):14–19, 1975.PubMedGoogle Scholar
  104. 104.
    McKeel DW, Askin FB: Ectopic hypophyseal hormonal cells in benign cystic teratoma of the ovary. Light microscopic histochemical dye staining and immunoperoxidase cytochemistry. Arch Pathol Lab Med (102):122–128, 1978.PubMedGoogle Scholar
  105. 105.
    Ueda G, Yamasaki M, Inoue H, Tanaka Y, Hiramatsu K, Saito J, Nishino T: A rare malignant ovarian mixed germ cell tumor containing pancreatic tissue with islet cells. Int J Gynecol Pathol (3).1220–1231, 1984.Google Scholar
  106. 106.
    Haselton TS, Kelehan P, Whittaker JS, Burslem RW, Turner L: Benign and maligant struma ovarii. Arch Pathol Lab Med (102) : 180–184, 1978.Google Scholar
  107. 107.
    Livolsi VA, Loferfo P, Feind C: Thyroglobulin in struma ovarii. J Surg Res (25):12–14, 1978.PubMedGoogle Scholar
  108. 108.
    Steeper TA, Mukai R: Solid ovarian teratomas: An immunocytochemical study of thirteen cases with clinicopathologic correlation. Pathol Ann (19):81–92, 1984.Google Scholar
  109. 109.
    Trojanowski JQ, Hickey WF: Human teratomas express differentiated neural antigens. An immunohistochemical study with anti-neurofilament, anti-glial filament, and anti-myelin basic protein monoclonal antibodies. Am J Pathol (115):383–389, 1984.PubMedGoogle Scholar
  110. 110.
    Aguirre P, Scully RE: Malignant neuroectodermal tumors of the ovary, primary and metastatic. A report of five cases. Am J Surg Pathol (6):283–292, 1982.PubMedGoogle Scholar
  111. 111.
    Kleinman GM, Young RH, Scully RE: Ependymoma of the ovary: report of three cases. Hum Pathol (15):632–638, 1984.PubMedGoogle Scholar
  112. 112.
    Bell DA, Woodruff JM, Scully RE: Ependymoma of the broad ligament. a report of two cases. Am J Surg Pathol (8):203–209, 1984.PubMedGoogle Scholar
  113. 113.
    Kurman RJ, Andrade D, Goebelsmann U, Taylor CR: An immunohistological study of steroid localization in Sertoli-Leydig tumors of the ovary and testis. Cancer (42):1772–1783, 1978.PubMedGoogle Scholar
  114. 114.
    Kurman RJ, Goebelsmann U, Taylor CR: Steroid localization in granulosa-theca tumors of the ovary. Cancer (43):2377–2384, 1979.PubMedGoogle Scholar
  115. 115.
    Gaffney EF, Majmudar B, Hertzler GL, Zane R, Furlong B, Breding E: Ovarian granulosa cell tumors—immunohistochemical localization of estradiol and ultrastructure, with functional correlations. Obstet Gynecol (61):311–319, 1983.PubMedGoogle Scholar
  116. 116.
    Gaffney EF, Majmudar B, Hewan-Lowe K: Ultrastructure and immunohistochemical localization of estradiol in three thecomas. Hum Pathol (15):153–160, 1984.PubMedGoogle Scholar
  117. 117.
    Kurman RJ, Goebelsmann U, Taylor CR: Localization of steroid hormones in functional ovarian tumors. In: DeLellis RA (ed). Diagnostic immunohistochemistry. Masson Publishing, USA, New York, 1981. pp. 137–148, (Masson monographs in diagnostic pathology).Google Scholar
  118. 118.
    Czernobiloky B: Immunohistochemistry of normal tissues of the female genital tract. Presented at XV International Congress of Int Acad Pathol, Miami Beach, Fla, 1984.Google Scholar
  119. 119.
    Benfield GFA, Tapper-Jones L, Stout TV: Androblastoma and raised serum α-fetoprotein with familial multinodular goitre. Case report. Br J Obstet Gynaecol (89):323–326, 1982.PubMedGoogle Scholar
  120. 120.
    Young RH, Perez-Atayde AR, Scully RE: Ovarian Sertoli-Leydig cell tumor with retiform and heterologous components. Report of a case with hepatocytic differentiation and elevated serum alpha-fetoprotein. Am J Surg Pathol (8):709–718, 1984.PubMedGoogle Scholar
  121. 121.
    Chumas JC, Rosenwaks Z, Mann NJ, Finkel G, Pastore J: Sertoli-Leydig cell tumor of the ovary producing α -fetoprotein. Int J Gynecol Pathol (3):213–219, 1984.PubMedGoogle Scholar
  122. 122.
    Lloyd RV, Shapiro B, Sisson JC, Kalff V, Thompson NW, Beierwaltes WA: An immunohistochemical study of pheochromocytomas. Arch Pathol Lab Med (108):541–544, 1984.PubMedGoogle Scholar
  123. 123.
    Nakajima T, Watanabe S, Sato Y, Kameya T, Hirota T, Shimosato Y: An immunoperoxidase study of S-100 protein distribution in normal and neoplastic tissues. Am J Surg Pathol (6):715–727, 1982.PubMedGoogle Scholar
  124. 124.
    Watts AE, Said JW, Banks-Schlegal S: Keratin and carcinoembryonic antigen in exfoliated mesothelial and malignant cells: an immunoperoxidase study. Am J Clin Pathol (80):671–676, 1983,Google Scholar
  125. 125.
    Epenetos AA, Canti G, Taylor-Papadimitrio UJ, Curling M, Bodmer WF: Use of two epithelium-specific monoclonal antibodies for diagnosis of malignancy in serous effusions. Lancet (2):1004–1006, 1982.PubMedGoogle Scholar
  126. 126.
    Battifora H, Kopinski MI: Distinction of mesothelium and reactive mesothelial cells from adenocarcinoma: an immunohistochemical study. Lab Invest (50):4A-5A, 1984.Google Scholar
  127. 127.
    Bast RC Jr, Klug TL, Schaetzl E, Lavin P, Niloff JM, Greber TF, Zurawski VR Jr, Knapp RC: Monitoring human ovarian carcinoma with a combination of CA125, CA 19–9, and carcinoembryonic antigen. Am J Obstet Gynecol (149): 533–559, 1984.Google Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1985

Authors and Affiliations

  • Robert E. Scully

There are no affiliations available

Personalised recommendations