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Pathology

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Marek’s Disease

Part of the book series: Developments in Veterinary Virology ((DVVI,volume 1))

Abstract

Observations made more than 50 years ago on naturally occurring cases provided the foundations of knowledge of the main gross and microscopic features of Marek’s disease (MD): these include enlargement of peripheral nerves as a result of infiltration by inflammatory or neoplastic lymphoid cells, and lymphoma formation in various sites (1,2). For many years there was much speculation on the nature and interrelationship of these lesions, but significant progress in understanding the pathology and pathogenesis of the disease was made only after experimental transmission became possible and the viral agent of the disease was isolated, during the 1960’s. Since then the main pathological events that occur during the development of MD have been elucidated (3), usually from studies on young genetically-susceptible chickens infected experimentally with pathogenic strains of MD virus (MDV). These events are described in this Chapter.

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  1. Houghton Poultry Research Station, Houghton, Huntingdon, Cambs., PE17 2DA, UK

    L. N. Payne

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© 1985 Martinus Nijhoff Publishing, Boston

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Payne, L.N. (1985). Pathology. In: Payne, L.N. (eds) Marek’s Disease. Developments in Veterinary Virology, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2613-7_3

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  • DOI: https://doi.org/10.1007/978-1-4613-2613-7_3

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