Abstract
Under natural conditions infection with Marek’s disease virus (MDV) occurs primarily in members of the genus Gallus (1), although it has been described rarely in other galliformes such as the turkey and quail (2,3 and see Chapter 2). Infection occurs in jungle fowl, both feral and those in zoological collections (1,4), but it is most important in domestic chickens where it is ubiquitous in poultry populations throughout the world. There is no evidence to suggest that the jungle fowl is a reservoir of infection of importance to commercial poultry. The source of infection for the domestic chicken is other infected domestic chickens. In the absence of vaccination Marek’s disease (MD) occurs in commercial poultry populations throughout the world (5) and mortality may reach 80% of a flock. However, it is a characteristic of the disease that its incidence varies greatly in infected flocks, and between houses and pens within a house on a single site (6). These variations can be greater than 10-fold.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Cho BR, Kenzy SG: Virologic and serologic studies of zoo birds for Marek’s disease virus infection. Infect Imnun (2): 809–814, 1975.
Kenzy SG, Cho BR: Transmission of classical Marek’s disease by affected and carrier birds. Avian Dis (13): 211–214, 1969.
Witter RL, Solomon JJ: Epidemiology of a herpesvirus of turkeys: possible sources and spread of infection in turkey flocks. Infect Immun (4): 356–361, 1971.
Weiss PA, Biggs PM: Leukosis and Marek’s disease viruses of feral Red Jungle fowl and domestic fowl in Malaya. J Natl Cancer Inst (49): 1713–1725, 1972.
Biggs PM: The world of poultry disease. Avian Pathol (11):281–300, 1982.
Biggs PM, Powell DG, Churchill AE, Chubb RC: The epizootiology of Marek’s disease. 1. Incidence of antibody, viraemia and Marek’s disease in six flocks. Avian Pathol (1): 5–25, 1972.
Witter RL, Moulthrop JI Jnr, Burgoyne GH, Connell HC: Studies on the epidemiology of Marek’s disease herpesvirus in broiler flocks. Avian Dis (14): 255–267, 1970.
Jackson CAW, Biggs PM, Bell RA, Lancaster FM, Milne BS: The epizootiology of Marek’s disease. 3. The inter-relationship of virus pathogenicity, antibody and the incidence of Marek’s disease. Avian Pathol (5): 105–123, 1976.
Witter RL, Solomon JJ, Champion LR, Nazerian K: Long-term studies of Marek’s disease infection in individual chickens. Avian Dis (15): 346–364, 1971.
Biggs PM, Payne LN: Studies on Marek’s disease. 1. Experimental transmission. J Natl Cancer Inst (39): 267–280, 1967.
Sevoian M, Chamberlain DM, Larose RN: Avian lymphomatosis. V. Airborne transmission. Avian Dis (7): 102–105, 1963.
Colwell WM, Schmittle SC: Studies on acute Marek’s disease. VII. Airborne transmission of the GA isolate. Avian Dis (12): 724–729, 1968.
Calnek BW, Hitchner SB: Localisation of viral antigen in chickens infected with Marek’s disease herpesvirus. J Natl Cancer Inst (43): 935–950, 1969.
Calnek BW, Adldinger HK, Kahn DE: Feather follicle epithelium: a source of enveloped and infectious cell-free herpesvirus from Marek’s disease. Avian Dis (14): 219–233, 1970.
Purchase HG: Virus-specific imnunofluorescent and precipitin antigens and cell-free virus in the tissues of birds infected with Marek’s disease. Cancer Res (30): 1898–1908, 1970.
Phillips PA, Biggs PM: Course of infection in tissues of susceptible chickens after exposure to strains of Marek’s disease virus and turkey herpesvirus. J Natl Cancer Inst (49): 1367–1373, 1972.
Biggs PM, Milne BS: Biological properties of a number of Marek’s disease virus isolates. In: Biggs PM, de Thé G, Payne IN (eds) Oncogenesis and Herpesviruses, IARC Scientific Publication No 2, International Agency for Research on Cancer, Lyon, 1972, pp 88–94.
Biggs PM, Payne LN, Milne BS, Churchill AE, Chubb RC: Field trials with an attenuated cell-associated vaccine for Marek’s disease. Vet Rec (87): 704–709, 1970.
Cho BR, Kenzy SG: Dual infection of chickens with acute and mild strains of Marek’s disease herpesvirus. Avian Dis (17): 390–395, 1973.
Sevoian M: Egg transmission studies of type II leukosis infection (Marek’s disease). Poult Sci (67): 1644–1646, 1968.
Solomon JJ, Witter RL, Stone HA, Champion LR: Evidence against embryo transmission of Marek’s disease virus. Avian Dis (14):752–762, 1970.
Witter RL: Epidemiological studies relating to the control of Marek’s disease. World’s Poult Sci J (26): 755–762, 1970.
Toth B: Experiments on the mode of spreading Marek’s disease virus. Acta Vet Acad Sci Hung (21): 255–259, 1971.
Kenzy SG, Biggs PM: Excretion of the Marek’s disease agent by infected chickens. Vet Rec (80): 565–568, 1967.
Witter RL, Burmester BR: Transmission of Marek’s disease with oral washings and feces fran infected chickens. Proc Soc Exp Biol Med. (124): 59–62, 1967.
Eidson CS, Schmittle SC: Studies on acute Marek’s disease. V. Attempted transmission of isolate GA with feces and nasal washings. Avian Dis (12):549–553, 1968
Carrozza JH, Fredrickson TN, Prince RP, Luginbuht RE: Role of desquamated epithelial cells. Avian Dis (17): 767–781, 1973.
Witter RL, Burgoyne GH, Burmester BR: Survival of Marek’s disease agent in litter and droppings. Avian Dis (12): 522–530, 1968.
Hlozânek I, Mach O, Jurajda V: Cell-free preparations of Marek’s disease virus from poultry dust. Folia Biol (Praha) (19): 118–123, 1973.
Calnek BW, Hitchner SB: Survival and disinfection of Marek’s disease virus and the effectiveness of filters in preventing airborne dissemination. Fault Sci (52): 35–43, 1973.
Burmester BR, Witter RL: Efficiency of commercial air filters against Marek’s disease virus. Appl Microbial (23): 505–508, 1972.
Eidson CS, Schmittle SC, Goode RB, Lal JB: Induction of leukosis tumors with the beetle Alphitobius diaperinus. Am J Vet Res (27): 1053–1057, 1966.
Beasley JN, Lancaster JL: Studies on the role of arthropods as vectors of Marek’s disease. Poult Sci (50): 1552, 1971.
Brewer RN, Reid WM, Johnson Joyce, Schmittle SC: Studies on acute Marek’s disease. VIII. The role of mosquitoes in transmission under experimental conditions. Avian Dis (13): 83–88, 1969.
Brewer RN, Reid WM, Botero H, Schmittle SC: Studies on acute Marek’s disease. Poult Sci (47): 2003–2012, 1968.
Long PL, Kenzy SG, Biggs PM: Relationship between Marek’s disease and coccidiosis. Vet Rec (83): 260–262, 1968.
Ianconescu M, Samberg Y: Etiological and immunological studies in Marek’s disease. II. Incidence of Marek’s disease precipitating antibodies in commercial flocks and in eggs. Avian Dis (15): 177–186, 1971.
Biggs PM, Shilleto RW, Milne BS: A quantitative sequential study of viraemia and neutralising antibody to HVT and MDV In a commercial flock vaccinated with HVT. Avian Pathol (8): 511–523, 1980.
Powell PC, Lawn AM, Payne LN, Rennie M, Ross LJN: The effect of virus dose on the development of Marek’s disease in two strains of chickens. Avian Pathol (9): 567–574, 1980.
Calnek BW: Influence of age at exposure on the pathogenesis of Marek’s disease. J Natl Cancer Inst (51): 929–939, 1973.
Gross WB: Effect of social stress on occurrence of Marek’s disease in chickens. Am J Vet Res (33): 2275–2279, 1972.
Kenzy SG, Long PL, Biggs PM: Relationship between Marek’s disease and coccidiosis. Vet Rec (86): 100–104, 1970.
Biggs PM, Long PL, Kenzy SG, Rootes DG: Relationship between Marek’s disease and coccidiosis. Vet Rec (83): 284–289, 1968.
Han P F-S, Smyth JR Jnr: The influence of growth rate on the development of Marek’s disease in chickens. Poult Sci (51):975–985, 1972.
Anderson DP, Eidson CS, Richey DJ: Age susceptibility of chickens to Marek’s disease. Am J Vet Res (32): 935–938, 1971.
Witter RL, Sharma JM, Solomon JJ, Champion LR: An age-related resistance of chickens to Marek’s disease: some preliminary observations. Avian Pathol (2): 43–54, 1973.
Sharma JM: Natural resistance to Marek’s disease at hatching in chickens lacking maternal antibody, and relationship between this early resistance and resistance acquired with age. Avian Dis (20): 311–323, 1976.
Chubb RC,Churchill AE: Effect of maternal antibody on Marek’s disease. Vet Rec (85): 303–305, 1969.
Calnek BW: Effects of passive antibody on early pathogenesis of Marek’s disease. Infect Immun (6): 193–198, 1972.
Churchill AE, Payne LN, Chubb RC: Immunization against Marek’s disease using a live attenuated virus. Nature (221): 744–747, 1969.
Purchase HG, Okazaki W, Burmester BR: Field trials with the herpes virus of turkeys (HVT) strain FC126 as a vaccine against Marek’s disease. Poult Sci (3): 775–783, 1971.
Schat KA, Calnek BW: Characterization of an apparently nononcogenic Marek’s disease virus. J Natl Cancer Inst (60): 1075–1082, 1978.
Biggs PM, Jackson CAW, Powell DG: The epizootiology of Marek’s disease. 2. The effect of supply flock, rearing, house and production house on the incidence of Marek’s disease. Avian Pathol (2): 127–134, 1973.
Witter RL: Epidemiology of Marek’s disease–a review. In: Biggs PM, de Thé G, Payne LN (eds) Oncogenesis and Herpesviruses, IARC Scientific Publication No 2, International Agency for Research on Cancer, Lyon, 1972, pp 111–122.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Martinus Nijhoff Publishing, Boston
About this chapter
Cite this chapter
Biggs, P.M. (1985). Spread of Marek’s Disease. In: Payne, L.N. (eds) Marek’s Disease. Developments in Veterinary Virology, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2613-7_12
Download citation
DOI: https://doi.org/10.1007/978-1-4613-2613-7_12
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9635-5
Online ISBN: 978-1-4613-2613-7
eBook Packages: Springer Book Archive