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Historical Review

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Marek’s Disease

Part of the book series: Developments in Veterinary Virology ((DVVI,volume 1))

Abstract

The purpose of this Chapter is to provide an introduction to the main studies and concepts concerning the nature and cause of Marek’s disease (MD) published between 1907, when the disease was first described by Marek (1), and the early 1960’s, when the transmissibility of MD was clearly established and rapid progress began to be made in its understanding. During this period there was great argument about the pathological nature and cause of MD, its relationship to other leukotic diseases, and its mode of natural transmission. The extensive literature published (see reviews 2–5) stands witness to this long debate and to the failure of the numerous studies to provide satisfactory answers to these questions. In retrospect, this was due to inadequate virological knowledge and techniques, lack of defined chickens for experimental reproduction of the disease, and inadequate facilities for properly controlled transmission studies.

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References

  1. Marek J: Multiple Nervenentzündung (Polyneuritis) bei Hühnern. Dtsch Tierarztl Wochenschr (15):417–421, 1907.

    Google Scholar 

  2. Burmester BR: Studies on fowl lymphomatosis. Ann NY Acad Sci (54):992–1003, 1952.

    Article  PubMed  CAS  Google Scholar 

  3. Chubb LG, Gordon RF: The avian leucosis complex - a review. Vet Rev Annot (3):97–120, 1957.

    Google Scholar 

  4. Biggs PM: Marek’s disease - current state of knowledge. Curr Top Microbiol Immunol (43):91–125, 1968.

    Google Scholar 

  5. Burmester BR, Purchase HG: The history of avian medicine in the United States. V. Insights into avian tumor virus research. Avian Dis (23):1–29, 1979.

    Article  PubMed  CAS  Google Scholar 

  6. Hutyra F, Marek J, Manninger R: Special Pathology and Therapeutics of the Diseases of Domestic Animals. 4th English Edition, 3 vols. Bailliere, Tindall and Cox, London, 1938.

    Google Scholar 

  7. Mócsy J: Marek József, a tudós, tanâr es ember. Magy Allatory Lap (7):321–330, 1952.

    Google Scholar 

  8. Hunt S: Dr. József Marek (1868–1952). Proc Australasian Poult Sci Conv, New Zealand, 5–7, 1972.

    Google Scholar 

  9. Kaupp BF: Paralysis of the domestic fowl. J An Ass. Instructors and Invest in Poultry Husbandry (7):25–31, 1921.

    Google Scholar 

  10. van der Walle N, Winkler-Junius E: De Neuritis-epizootie bij Kippen to Barneveld in 1921. T Vergelijk Geneesk Gezondhleer (10):34–50, 1924.

    Google Scholar 

  11. May HC, Tittsler RP, Goodner K: Field observations and laboratory findings in “Paralysis” of the domestic fowl. Rhode Island Agric Exper Sta Bull (202):1925.

    Google Scholar 

  12. Doyle LP: Neuritis in chickens. J An Vet Med Assoc (68):622–630, 1926.

    Google Scholar 

  13. Pappenheimer AM, Dunn LC, Cone VA: A study of fowl paralysis (neuro-lymphomatosis gallinarum). Storrs Agric Exper Sta Bull (143):187–290, 1926.

    Google Scholar 

  14. Pappenheimer AM, Dunn LC, Cone VA: Studies on fowl paralysis (neuro-lymphomatosis gallinarum). I. Clinical features and pathology. J Exp Med (49):63–86, 1929.

    Article  PubMed  CAS  Google Scholar 

  15. Pappenheimer AM, Dunn LC, Seidlin SM: Studies on fowl paralysis (neuro-lymphomatosis gallinarum). II. Transmission experiments. J Exp Med (49):87–102, 1929.

    Article  PubMed  CAS  Google Scholar 

  16. Dobberstein J, Haupt H: Ein Beitrag zur Polyneuritis des Geflügels. Z Infektionsk Hyg Haustiere (31):58–77, 1927.

    Google Scholar 

  17. Thomas AD: Leg-weakness in poultry. A preliminary note on the occurrence of a specific paralysis in South Africa. J South Afr Vet Med Assoc (1):67–72, 1928.

    Google Scholar 

  18. Galloway IA: Discussion on encephalo-myelitis of man and animals. Proc Roy Soc Med (22):1167–1171, 1929.

    Google Scholar 

  19. Emoto O, Miyamoto K: Studies on the fowl paralysis. J Jpn Soc Vet Sci (9):309–326, 1930.

    Google Scholar 

  20. Patterson FD, Wilcke HL, Murray C, Henderson EW: So-called range paralysis of the chicken. J An Vet Med Assoc (81):747–767, 1932.

    Google Scholar 

  21. Gibbs CS: Observations and experiments with neurolymphomatosis and the leukotic diseases. Mass Agric Exper Sta Bull (337):1–31, 1936.

    Google Scholar 

  22. Johnson EP: The etiology and histogenesis of leucosis and lymphomatosis of fowls. Virginia Polytech Inst Tech Bull (56):3–32, 1934.

    Google Scholar 

  23. Furth J: Lymphomatosis in relation to fowl paralysis. Arch Path (20):379–428, 1935.

    Google Scholar 

  24. Jungherr E: Studies on fowl paralysis. I. Diagnosis. Storrs Agric Exper Sta Bull (200):1934.

    Google Scholar 

  25. Jungherr E: Studies on fowl paralysis. 2. Transmission experiments. Storrs Agric Exper Sta Bull (218):1–47, 1937.

    Google Scholar 

  26. Durant AJ, McDougle HC: Studies on the origin and transmission of fowl paralysis (neurolymphomatosis) by blood inoculation. Missouri Agric Exp Sta Res Bull (304):1–23, 1939.

    Google Scholar 

  27. Warrack GH, Dalling T: So-called “fowl paralysis”. Vet J (88):2843, 1932.

    Google Scholar 

  28. Blakemore F: The nature of fowl paralysis (neurolymphomatosis). J Comp Pathol (52):144–159, 1939.

    Google Scholar 

  29. Lerche F, Fritzsche K: Die Aetiologie der Geflügellähme. Z Infekt-Kr Haustiere (44):11–42, 1933.

    Google Scholar 

  30. Lerche F, Fritzsche K: Histopathologie and Diagnostik der Geflügellähme. Z Infekt-Kr Haustiere (45):89–109, 1934.

    Google Scholar 

  31. Biggs PM, Payne LN: Studies on Marek’s disease. I. Experimental transmission. J Natl Cancer Inst (39):237–280, 1967.

    Google Scholar 

  32. Churchill AE, Biggs PM: Agent of Marek’s disease in tissue culture. Nature (215):528–530, 1967.

    Article  PubMed  CAS  Google Scholar 

  33. Nazerian K, Solomon JJ, Witter RL, Burmester BR: Studies on the etiology of Marek’s disease. II. Finding of a herpesvirus in cell culture. Proc Soc Exp Biol Med (127):177–182, 1968.

    PubMed  CAS  Google Scholar 

  34. Thomas JC, Hamilton HP: Fowl paralysis: an analysis of one thousand cases. Vet J (91):526–536, 1935.

    Google Scholar 

  35. Ellerman V: The Leucosis of Fowls and Leucemia Problems. Gyldendal London, 1922.

    Google Scholar 

  36. Patterson FD: Fowl leukosis. J An Vet Med Ass (88):32–43, 1936.

    Google Scholar 

  37. Anon: Poultry Disease Investigations at the U.S. Regional Poultry Research Laboratory. Misc Pub No 609 U.S. Department of Agriculture, Washington D.C. 27 pp. 1946.

    Google Scholar 

  38. Anon: Tentative pathologic nomenclature. Am J Vet Res (2):116, 1941.

    Google Scholar 

  39. Burmester BR: Studies on the transmission of avian visceral lymphomatosis. II. Propagation of lymphomatosis with cellular and cell-free preparations. Cancer Res (7):786–797, 1947.

    PubMed  CAS  Google Scholar 

  40. Gross MA, Burmester BR, Walter W: Pathogenicity of a viral strain (RPL 12) causing avian visceral lymphomatosis and related neoplasms. I. Nature of the lesions. J Natl Cancer Inst (22):83101, 1959.

    Google Scholar 

  41. Burmester BR, Gentry RF: The transmission of avian visceral lymphomatosis by contact. Cancer Res (14):34–42, 1954.

    PubMed  CAS  Google Scholar 

  42. Cottral GE, Burmester BR, Waters NF: Egg transmission of avian lymphomatosis. Poult Sci (33):1174–1184, 1954.

    Google Scholar 

  43. Waters NF: Etiological relationship of visceral and neural lymphomatosis. Poult Sci (33):365–373, 1954.

    Google Scholar 

  44. Davis OS, Doyle LP: Studies in avian leucosis. I. The transmissibility of visceral lymphomatosis. Am J Vet Res (8):103–112, 1947.

    PubMed  CAS  Google Scholar 

  45. Davis OS, Doyle LP: Studies in avian leucosis. IV. Further transmission of visceral lymphomatosis. Am J Vet Res (10):85–91, 1949.

    PubMed  CAS  Google Scholar 

  46. Durrant AJ, McDougle HC: Further investigations of the transmission of fowl paralysis (neurolymphomatosis) by direct transfusion. Missouri Agric Exp Sta Res Bull (393):1–18, 1945.

    Google Scholar 

  47. Blakemore F: Further observations on the demonstration of an infective agent in the tissues of fowls affected with fowl paralysis (neurolymphomatosis). J Camp Pathol (55):1–18, 1945.

    Google Scholar 

  48. Hutt FB, Cole RK: Problems concerning leucosis and its control. Proc 10th Worlds Poult Cong Edinburgh, 1954, pp 197–201.

    Google Scholar 

  49. Hutt FB, Cole RK: Control of leukosis in fowl. J Am Vet Med Ass (131):491–495, 1957.

    CAS  Google Scholar 

  50. Cottral GE: The enigma of avian leukosis. Proc 89th Ann Meet Am Vet Med Ass 285–293, 1952.

    Google Scholar 

  51. Campbell JG: Neoplastic disease of the fowl with special reference to its history, incidence and seasonal variation. J Comp Pathol (55):308–321, 1945.

    Google Scholar 

  52. Campbell JG: Leucosis and fowl paralysis compared and contrasted. Vet Rec (68):527–529, 1956.

    Google Scholar 

  53. Biggs PM: A discussion on the classification of the avian leucosis complex and fowl paralysis. Br Vet J (117):326–334, 1961.

    Google Scholar 

  54. Campbell JG: A proposed classification of the leucosis complex and fowl paralysis. Br Vet J (117):316–325, 1961.

    PubMed  CAS  Google Scholar 

  55. Biggs PM: Some observations on the properties of cells from the lesions of Marek’s disease and lymphoid leukosis. Proc 13th Symp Colston Research Society, Butterworths Scientific Publications, London, 1962, pp 83–99.

    Google Scholar 

  56. Biggs PM: The avian leucosis complex. World’s Poult Sci J (20): 78–91, 1964.

    Article  Google Scholar 

  57. Sevoian M: On the terminology and classification of the avian leukosis complex. Avian Dis (11):98–103, 1967.

    Article  PubMed  CAS  Google Scholar 

  58. Campbell JG: Tumours of the Fowl. Heinemann, London, 1969.

    Google Scholar 

  59. Sevoian M, Chamberlain DM, Counter F: Avian lymphomatosis. I. Experimental reproduction of the neural and visceral forms. Vet Med (57):500–501, 1962.

    Google Scholar 

  60. Sevoian M, Chamberlain DM: Avian lymphomatosis. II. Experimental reproduction of the ocular form. Vet Med (57):608–609, 1962.

    Google Scholar 

  61. Biggs PM, Payne LN: Transmission experiments with Marek’s disease (fowl paralysis). Vet Rec (75):177–179, 1963.

    Google Scholar 

  62. Biggs PM, Purchase HG, Bee BR, Dalton PJ: Preliminary report on acute Marek’s disease (fowl paralysis) in Great Britain. Vet Rec (77):1339–1340, 1965.

    Article  PubMed  CAS  Google Scholar 

  63. Benton WJ, Cover MS: The increased incidence of visceral lymphomatosis in broiler aged chickens. Avian Dis (1):320–327, 1957.

    Article  Google Scholar 

  64. Benton WJ, Cover MS, Krauss WC: The incidence of avian leukosis in broilers at processing. Avian Dis (6):430–435, 1962.

    Article  Google Scholar 

  65. Churchill AE, Payne LN, Chubb RC: Immunization against Marek’s disease using a live attenuated virus. Nature (221):744–747, 1969.

    Article  PubMed  CAS  Google Scholar 

  66. Okazaki W, Purchase HG, Burmester BR: Protection against Marek’s disease by vaccination with a herpesvirus of turkeys. Avian Dis (14):413–429, 1970.

    Article  PubMed  CAS  Google Scholar 

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© 1985 Martinus Nijhoff Publishing, Boston

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Payne, L.N. (1985). Historical Review. In: Payne, L.N. (eds) Marek’s Disease. Developments in Veterinary Virology, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2613-7_1

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  • DOI: https://doi.org/10.1007/978-1-4613-2613-7_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9635-5

  • Online ISBN: 978-1-4613-2613-7

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