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Prostaglandin Synthase-Dependent Cooxidation and Aromatic Amine Carcinogenesis

  • Chapter
Arachidonic Acid Metabolism and Tumor Initiation

Part of the book series: Prostaglandins, Leukotrienes, and Cancer ((PLAC,volume 2))

Abstract

Aromatic amines were among the first chemical agents recognized to be carcinogenic. This suspicion was first voiced by Rehn in 1895 (1) after he noticed three cases of bladder cancer among workers employed at an amine-derived dye factory in Germany. Prior to the industrialized production of synthetic organic chemicals (thus occasioning long-term exposure of significant amounts to many people), this disease was sufficiently rare to make the situation noteworthy. As large-scale human exposure continued, particularly in the virtual absence of sound hygenic practices, enough cases of malignant disease arose to permit an epidemiological assignment of cause. In this way, 4-aminobiphenyl was identified as a human carcinogen (and its use banned) in 1955 (2), and both benzidine and 2-naphthylamine were similarly classified, following indications derived from animal models, in 1954. (3). The dog was initially selected as a test species of choice for chemically-induced bladder cancer because of its sensitivity to the disease. Dosing studies of the three compounds cited above showed that 4-aminobiphenyl is the most potent, followed by 2-naphthylamine (4), while benzidine clearly shows a lower order of response (5). These studies, and those of the induction of liver tumors in rodents (6), indicate that individual aromatic amines of superficially similar structure differ widely in their carcinogenic potential. In addition, the disparate sites of tumor formation shown by these compounds indicates that they require enzymatic transformation prior to eliciting their effects, as described in more detail in other chapters in this volume.

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Authors
  1. John R. Rice
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  2. Terry V. Zenser
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  3. Bernard B. Davis
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Editors and Affiliations

  1. Wayne State University, Detroit, Michigan, USA

    Lawrence J. Marnett

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Rice, J.R., Zenser, T.V., Davis, B.B. (1985). Prostaglandin Synthase-Dependent Cooxidation and Aromatic Amine Carcinogenesis. In: Marnett, L.J. (eds) Arachidonic Acid Metabolism and Tumor Initiation. Prostaglandins, Leukotrienes, and Cancer, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2611-3_4

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  • DOI: https://doi.org/10.1007/978-1-4613-2611-3_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9634-8

  • Online ISBN: 978-1-4613-2611-3

  • eBook Packages: Springer Book Archive

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