Arachidonic Acid Metabolism and Tumor Initiation

  • Lawrence J. Marnett
Part of the Prostaglandins, Leukotrienes, and Cancer book series (PLAC, volume 2)


Chapter 1 of this volume describes the importance of reactions of electrophiles with nucleic acids in the initiation phase of carcinogenesis. Compounds that covalently bind to or otherwise damage DNA (e.g., by induction of strand scission) can alter the functional properties of the DNA molecule. The genetic changes that result may be a critical component of initiation. Two ways by which arachidonic acid metabolism can lead to DNA damage have been studied. In the first, metabolites of arachidonic acid bind to DNA and induce mutation or cell transformation. In the second, cooxidations by oxidizing agents generated during fatty acid hydroperoxide metabolism metabolically activate endogenous or xenobiotic compounds to derivatives that react with DNA. Both types of DNA damage occur during arachidonic acid metabolism in vitro and are discussed in this chapter.


Aromatic Amine Peroxyl Radical Arachidonic Acid Metabolism Polycyclic Hydrocarbon Fatty Acid Hydroperoxide 
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© Martinus Nijhoff Publishing, Boston 1985

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  • Lawrence J. Marnett

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