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Clinical Trials in Adult ANLL: An Overview

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Part of the book series: Developments in Oncology ((DION,volume 33))

Abstract

Tremendous advances have been made over the past 20 years in the treatment of acute non lymphocytic leukemia (ANLL) in adults. This chapter will provide a historical perspective on the emergence of modern chemotherapy against ANLL. By reviewing past and current clinical trials, an appreciation of the stepwise progress which has been made in the understanding and management of this disease may be gained.

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References

  1. Freireich EJ et al: Cytarabine for acute leukemia in adults. Arch. Inter. Med. 133: 251–259, 1974.

    Article  Google Scholar 

  2. Ellison RR et al: Arabinosyl cytosine: A useful agent in the treatment of acute leukemia in adults. Blood 32: 507–523, 1968.

    PubMed  CAS  Google Scholar 

  3. Weil M, Glidewell OJ, Jaquillat C: Daunorubicin in the therapy of acute granulocytic leukemia. Cancer Res. 33: 921–928, 1973.

    PubMed  CAS  Google Scholar 

  4. Wiernik PH, Serpick AA: A randomized clinical trial of daunorubicin and a combination of prednisone, vincristine, 6-mercaptopurine and methotrexate in adult nonlymphocytic leukemia. Cancer Res. 32: 2023–2026, 1972.

    PubMed  CAS  Google Scholar 

  5. Boggs DR: The kinetics of neutrophilic leukocytes in health and disease. Semin. Hematol. 4: 359–386, 1967.

    PubMed  CAS  Google Scholar 

  6. Carey RW et al: Comparative study of cytosine arabinoside therapy alone and combined with thioguanine, mercaptopurine or daunorubicin in acute myelocytic leukemia. Cancer 36: 1560–1566, 1975.

    Article  PubMed  CAS  Google Scholar 

  7. Wiernik PH, Glidewell OJ et al: A comparative trial of daunorubicin, cytosine arabinoside, and thioguanine and a combination of the three agents for the treatment of acute myelocytic leukemia. Med. Ped. Onc. 6: 261–277, 1979.

    Article  CAS  Google Scholar 

  8. Weirnik PH, Schimpff SC et al: Randomized clinical comparison of daunorubicin alone with a combination of daunorubicin, cytosine arabinoside, 6-thioguanine and pyrimethamine for the treatment of acute nonlymphocytic leukemia. Cancer Treat. Rep. 60: 41–53, 1976.

    Google Scholar 

  9. Clarkson BD: Acute myelocytic leukemia in adults. Cancer 30: 1572–1582, 1972.

    Article  PubMed  CAS  Google Scholar 

  10. Yates JW, Holland JF et al: Cytosine arabinoside and daunorubicin therapy in acute nonlymphocytic leukemia. Cancer Chem. Rep. 57 (4): 485–488, 1973.

    CAS  Google Scholar 

  11. Rodriguez V, Hart JS, Freireich EJ et al: POMP combination chemotherapy of adult acute leukemia. Cancer 32: 69–75, 1973.

    Article  PubMed  CAS  Google Scholar 

  12. Bodey GP, Coltman CA et al: Chemotherapy of acute leukemia. Arch. Intern. Med. 133: 260–266, 1974.

    Article  PubMed  CAS  Google Scholar 

  13. Vaughan WP, Karp JE, Burke PJ: Long chemotherapy-free remissions after single cycle timed sequential chemotherapy for acute myelocytic leukemia. Cancer 45: 859–865, 1980.

    Article  PubMed  CAS  Google Scholar 

  14. Lewis JP, Linman JW et al: Randomized clinical trial of cytosine arabinoside and 6-thioguanine in remission induction and consolidation of adult nonlymphocytic acute leukemia. Cancer 39: 1387–1396, 1977.

    Article  PubMed  CAS  Google Scholar 

  15. Preisler H, Bjornsson S et al: Remission induction in acute nonlymphocytic leukemia: Comparison of a seven-day and ten-day infusion of cytosine arabinoside in combination with adriamycin. Med. Ped. Onc. 7: 269–275, 1979.

    Article  CAS  Google Scholar 

  16. Weinstein HJ, Mayer RJ et al: Treatment of acute myelogenous leukemia in children and adults. NEJM 303: 473–478, 1980.

    Article  PubMed  CAS  Google Scholar 

  17. Keating MJ, Smith TL et al: Four-year experience with anthracycline, cytosine arabinoside, vincristine and prednisone combination chemotherapy in 325 adults with acute leukemia. Cancer 47: 2779–2788, 1981.

    Article  PubMed  CAS  Google Scholar 

  18. Lewis JP, Meyers F et al: Continuous infusion daunomycin in remission induction of acute nonlymphocytic leukemia. Blood 62: 205a, 1983.

    Google Scholar 

  19. Gale RP, Cline MJ: High remission induction rate in acute myeloid leukemia. Lancet (1): 497–499, 1977.

    Google Scholar 

  20. Rees JKH, Sandler RM et al: Treatment of acute myeloid leukemia with a triple cytotoxic regime: DAT. Br. J. Cancer 36: 770–776, 1977.

    Article  PubMed  CAS  Google Scholar 

  21. Rai KR, Holland JF, Glidewell OJ: Improvement of remission induction of acute myelocytic leukemia. Proc. ASCO 16: 265, 1975.

    Google Scholar 

  22. Chang P, Wiernik PH, Reich SD et al: Prediction of response to cytosine arabinoside and daunorubicin in acute nonlymphocytic leukemia. In: Therapy of Acute Leukemias, Mandelli (ed), Rome, Italy, Lombardo Editore, 1979, pp. 430–433.

    Google Scholar 

  23. Yates J, Glidewell OJ, Wiernik PH et al: Cytosine arabinoside with daunorubicin or adriamycin for therapy of acute myelocytic leukemia: A CALGB study. Blood 60: 454–462, 1982.

    PubMed  CAS  Google Scholar 

  24. Yates J, Glidewell OJ, Wiernik PH et al: Cytosine arabinoside with daunorubicin or adriamycin for therapy of acute myelocytic leukemia: A CALGB study. Blood 60: 454–462, 1982.

    PubMed  CAS  Google Scholar 

  25. Peterson BA, Bloomfield CD: Long term disease free survival in acute nonlymphocytic leukemia. Blood 57: 1144 1147, 1981.

    Google Scholar 

  26. Gale RP, Foon KA et al: Intensive chemotherapy for acute myelogenous leukemia. Annals Int. Med. 94: 753–757, 1981.

    CAS  Google Scholar 

  27. Weinstein HJ, Mayer RJ et al: Chemotherapy for acute mye-logenous leukemia in children and adults: VAPA update. Blood 62: 315–319, 1983.

    PubMed  CAS  Google Scholar 

  28. Preisler H, Kirshner J, Raza A, Davis R: Comparison of 3 remission induction regimens for the treatment of acute nonlymphocytic leukemia. Blood 62: 206a, 1983.

    Google Scholar 

  29. Preisler H, Anderson K et al: Comparison of survival of patients with acute nonlymphocytic leukemia receiving maintenance chemotherapy or bone marrow transplantation in 1st remission. Proc. ASCO 2: 177, 1983.

    Google Scholar 

  30. Champlin R, Zighelboim W et al: Treatment of acute myelogenous leukemia — bone marrow transplantation vs. consolidation chemotherapy. Proc. ASCO 2: 180, 1983.

    Google Scholar 

  31. Foon KA, Gale RP: Controversies in the therapy of acute myelogenous leukemia. Amer. J. Med. 72: 963–979, 1982.

    Article  PubMed  CAS  Google Scholar 

  32. Dutcher JP, Markus S, Wiernik PH et al: Intensive maintenance therapy in acute nonlymphocytic leukemia. Blood 62: 201a, 1983.

    Google Scholar 

  33. Freireich EJ, Keating MJ, Gehan EA et al: Therapy of acute myelogenous leukemia. Cancer 42: 874–882, 1978.

    Article  PubMed  CAS  Google Scholar 

  34. Hines JD, Oken MM, Mazza J et al: High dose cytosine arabinoside and M-AMSA induction and consolidation in acute nonlymphocytic leukemia. Blood 62: 203a, 1983.

    Google Scholar 

  35. Arlin ZA, Flomenberg N et al: Treatment of acute leukemia in relapse with AMSA in combination with cytosine arabinoside and thioguanine. Cancer Clin. Trials 4: 317–321, 1981.

    CAS  Google Scholar 

  36. McCredie KB, Keating MJ, Estey EH et al: Use of AMSA, cytosine arabinoside, vincristine, prednisone combination in poor risk patients in acute leukemia. Proc. AACR 22: 479, 1981.

    Google Scholar 

  37. Kahn SB, Conroy JF, Bulova S et al: AMSA and 5-azacytidinc therapy of acute leukemia. Blood 58: 143a, 1981.

    Google Scholar 

  38. Hurd DD, Peterson BA, Bloomfield CD: AMSA, VP-16, cytosine arabinoside, and 6-thioguanine in the treatment of relapsec and refractory acute nonlymphocytic leukemia. Blood 58: 142a, 1981.

    Google Scholar 

  39. Hines JD, Oken MM, Mazza J et al: High dose cytosine arabinoside and AMSA in refractory acute nonlymphocytic leukemia. Blood 58: 142a, 1981.

    Google Scholar 

  40. Herzig RH, Wolff SN, Karanes C et al: High dose cytosine arabinoside therapy for refractory leukemia. Blood 62: 361–369, 1983.

    PubMed  CAS  Google Scholar 

  41. Wolff SN: High dose cytosine arabinoside and daunorubicin for acute nonlymphocytic leukemia in first remission. Proc. ASCO 25: 1984 (in press).

    Google Scholar 

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© 1985 Martinus Nijhoff Publishing, Boston

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Rooney, M. (1985). Clinical Trials in Adult ANLL: An Overview. In: Baker, L., Valeriote, F., Ratanatharathorn, V. (eds) Biology and Therapy of Acute Leukemia. Developments in Oncology, vol 33. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2609-0_11

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  • DOI: https://doi.org/10.1007/978-1-4613-2609-0_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9633-1

  • Online ISBN: 978-1-4613-2609-0

  • eBook Packages: Springer Book Archive

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