Abstract
The low-grade malignant B-cell lymphoproliferative disorders with leukemic cells in the peripheral blood (LMBLL) are practically all included in what is usually called chronic lymphocytic leukemia (CLL). When it became obvious that CLL was a heterogenous disease, it was subdivided in several groups, e.g. according to the Kiel classification [1]. New entities such as immunocytoma, prolymphocytic leukemia, and centrocytic lymphoma, were separated from CLL. Our original aim was to investigate the ‘classical’ CLL for possible presence of specific chromosomal aberrations. The study includes patients within the new subgroups, but only those who presented with a leukemic picture, i.e. a blood lymphocyte count of at least 5 × 109/1.
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References
Lennert K. (1978). Malignant lymphomas other than Hodgkin’s disease. Handbuch der speziellen patologischen Anatomie and Histologie. Band 1, Teil 3 B. Berlin, Heidelberg, New York: Springer-Verlag.
Mitelman F and Levan G (1978). Clustering of aberrations to specific chromosomes in human neoplasms. III. Incidence and geographic distribution of chromosome aberrations in 856 cases. Hereditas 89: 207–232.
Rundles RW and Moore JO (1978). Chronic lymphocytic leukemia. Cancer 42: 941–945.
Möller G (ed.) (1975). Subpopulation of B lymphocytes. Transplant Rev 24:1–236.
Robèrt KH, Möller E, Gahrton G et al. (1978). B-cell activation of peripheral blood lymphocytes from patients with chronic lymphatic leukaemia. Clin Exp Immunol 33: 302308.
Gahrton G, Zech L, Robèrt K-H and Bird AG (1979). Mitogenic stimulation of leukemia cells by Epstein-Barr virus. N Engl J Med 301: 438–439.
Robèrt K-H (1979). Induction of monoclonal antibody synthesis in malignant human B-cells by polyclonal B-cell activators. Immunol Rev 48: 123–143.
Gahrton G, Robèrt K-H, Friberg K et al. (1980). Extra chromosome 12 in chronic lymphocytic leukemia. Lancet 1: 146–147.
Gahrton G, Robèrt K-H, Friberg K et al. (1980). Nonrandom chromosomal aberrations in chronic lymphocytic leukemia revealed by polyclonal B-cell-mitogen stimulation. Blood 56: 640–647.
Robèrt K-H, Gahrton G, Friberg K et al. (1982). Extra chromosome 12 and prognosis in chronic lymphocytic leukaemia. Scand J Haematol 28: 163–168.
Robèrt K-H, Gahrton G, Friberg K et al. (1982). Extra chromosome 12 and prognosis in chronic lymphocytic leukaemia. Scand J Haematol 28: 163–168.
Rai KR, Sawitsky A, Cronkite EP et al. (1975). Clinical staging of chronic lymphocytic leukemia. Blood 46: 219–234.
Binet JL, Auquier A, Dighiero G et al. (1981). A new prognostic classification of chronic lymphocytic leukemia derived from multivariate survival analysis. Cancer 48: 196–206.
Ideström K, Kimby E, Björkholm M et al. (1982). Treatment of chronic lymphocytic leukaemia and well-differentiated lymphocytic lymphoma with continuous low-or intermittent high-dose prednimustine versus chlorambucil/prednisolone. Eur J Cancer Clin Oncol 18: 1117–1123.
Beyum A (1968). Separation of leukocytes from blood and bone marrow. Scand J Clin Lab Invest Suppl 97, 21: 31–50.
Caspersson T, Lomakka G and Zech L (1971). The 24 fluorescence patterns of the human metaphase chromosome - distinguishing characters and variability. Hereditas 67: 89102.
ISCN (1981). Report of the standing committee on human cytogenetic nomenclature. Cancer Genet Cytogenet 31: 5–32.
Juliusson G, Robèrt K-H, Öst A et al. (1984). Del (3) (p13) in B-prolymphocytic leukemia - a new nonrandom chromosomal aberration possibly correlated to the c-ras oncogene. (In preparation).
Monta M, Minowada J and Sandberg AA (1981). Chromosomes and causation of human cancer and leukemia. XLV. Chromosome patterns in stimulated lymphocytes of chronic lymphocytic leukemia. Cancer Genet Cytogenet 3: 293–306.
Vandati M, Graafland H and Emberger JM (1983). Karyotype analysis of B-lymphocytes transformed by Epstein-Barr virus in 21 patients with B-cell chronic lymphocytic leukemia. Hum Genet 63: 327–331.
Han T, Ozer H, Sadamori N et aI. (1984). Prognostic importance of cytogenetic abnormalities in patients with chronic lymphocytic leukemia. N Engl J Med 310: 288–292.
Gahrton G, Robèrt K-H, Friberg K et al. (1982). Cytogenetic mapping of the duplicated segment of chromosome 12 in lymphoproliferative disorders. Nature 297: 513–514.
Jhanwar SC, Neel BG, Hayward WS and Chaganti RSK (1983). Localization of c-ras oncogene family of human germ-like chromosomes. Proc Nat Acad Sci USA 80: 4794–4797.
Klein G (1981). The role of gene dosage and genetic transpositions in carcinogenesis. Nature 294: 313–318.
Bertino JR, Silber R, Freeman M et al. (1963). Studies on normal and leukemic leukocytes. IV. Tetrohydrofolate-dependent enzyme systems and dihydrofolic reductase. J Clin Invest 42: 1899–1907.
Gerald PS and Grzeschik KI-I (1984). Report of the committee on the genetic constitution of chromosomes 10, 11 and 12. Cytogenet Cell Genet 37:103–126.
Mitelman F (1983). Catalogue of chromosome aberrations in cancer. Cytogenet Cell Genet 36: 1–516.
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© 1985 Martinus Nijhoff Publishers, Boston
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Gahrton, G., Juliusson, G., Robert, K.H., Friberg, K., Zech, L. (1985). Chromosomal aberrations in leukemic low-grade malignant B-cell lymphoproliferative neoplasias. In: Cavalli, F., Bonadonna, G., Rozencweig, M. (eds) Malignant Lymphomas and Hodgkin’s Disease: Experimental and Therapeutic Advances. Developments in Oncology, vol 32. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2607-6_9
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DOI: https://doi.org/10.1007/978-1-4613-2607-6_9
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