The use of chemotherapy for localized large cell lymphoma. Results from the University of Arizona
Historically radiotherapy (XRT) alone has been used to treat non-Hodgkin’s lymphoma (NHL) of limited extent . The rationale for this approach has included the ability to eradicate tumor in a treatment field and the apparent success of this approach in limited stage Hodgkin’s disease (HD). However, it has become clear that the NHL are a diverse group of lymphoid neoplasms clearly distinguishable from HD. The prototype curable NHL is the large cell or ‘histiocytic’ lymphoma. This differs from HD in that it occurs in older patients, has a high growth fraction with a propensity for rapid hematogenous dissemination, and fails to exhibit the classic radiation dose-response curve . Thus, it is not surprising that many, if not the majority of patients with large cell lymphoma, fail to be cured with radiotherapy alone .
KeywordsLymphoma Oncol Doxorubicin Methotrexate Cyclophosphamide
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