Abstract
The relapse-free survival (RFS) rate for Stage III Hodgkin’s disease treated by conventional total nodal irradiation (TNI) alone (early 1970’s) was disappointingly low [1–4]. The development of successful combination chemotherapy by National Cancer Institute workers [5] led SWOG, in 1971, to devise a single arm study (SWOG-160, CAR-1) consisting of three MOPP cycles followed by TNI in Pathologic Stages IIB, IIIA, and IIIB Hodgkin’s disease. This trial, which was completed in 1975, achieved a complete response (CR) rate of 88% and an actuarial 5-year survival and RFS of 78% and 68% respectively [6]. Improvement in survival and promising results obtained on another SWOG study with the addition of low dose bleomycin (LDB 2 mg/m2) to MOPP [7, 8] prompted SWOG to initiate, in October 1975, a randomized trial of chemotherapy (CT) alone compared to CT plus TNI for Stages IIIA and IIIB Hodgkin’s disease with LDB added to the CT regimen (SWOG-7518, CAR-2) [9, 10] (Fig. 1 and Table I).
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References
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© 1985 Martinus Nijhoff Publishers, Boston
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Grozea, P.N. et al. (1985). Chemotherapy alone versus combined modality therapy for Stage III Hodgkin’s disease: A five-year follow-up of a Southwest Oncology Group study (SWOG-7518) USA. In: Cavalli, F., Bonadonna, G., Rozencweig, M. (eds) Malignant Lymphomas and Hodgkin’s Disease: Experimental and Therapeutic Advances. Developments in Oncology, vol 32. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2607-6_36
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DOI: https://doi.org/10.1007/978-1-4613-2607-6_36
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