Abstract
Identification of activated cellular transforming genes in a variety of neoplasms has been greatly facilitated by the use of the NIH 3T3 transfection assay. A unique property of the NIH 3T3 cells is that they have the ability to undergo transformation following integration of dominantly acting genes, possibly because they have already progressed some way down the path toward overt malignancy. These cells have the ability to be transformed by a variety of transforming genes and therefore may represent a multi potential cell capable of responding to many different growth stimulatory signals.
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References
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© 1985 Martinus Nijhoff Publishers, Boston
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Lane, M.A., Stephens, H.A.F., Tobin, M.B., Doherty, K. (1985). Stage specific transforming genes in lymphoid neoplasms. In: Cavalli, F., Bonadonna, G., Rozencweig, M. (eds) Malignant Lymphomas and Hodgkin’s Disease: Experimental and Therapeutic Advances. Developments in Oncology, vol 32. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2607-6_13
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DOI: https://doi.org/10.1007/978-1-4613-2607-6_13
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