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DNA content and proliferation in non-Hodgkin’s lymphoma: Flow cytofluorometric DNA analysis in relation to the Kiel classification

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Part of the book series: Developments in Oncology ((DION,volume 32))

Abstract

The Rappaport classification is widely used for diagnosis and treatment of non-Hodgkin’s lymphomas (NHL) [1–3]. However, it has become increasingly inconsistent with the rapidly changing concepts of the functional diversity of the immune system. Attempts have, therefore, been made to incorporate immunologic concepts into the morphologic classification of NHL [4, 5]. The clinical applicability of these newer classifications as well as their capacity to identify biologically distinct tumor groups is currently under study.

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References

  1. Fisher RI, Hubbard SM, DeVita VT et al. (1981). Factors predicting long-term survival in diffuse mixed, histiocytic, or undifferentiated lymphoma. Blood 58: 45–51.

    PubMed  CAS  Google Scholar 

  2. Rosenberg SA (1979). Non-Hodgkin’s lymphoma–Selection of treatment on the basis of histologic type. Engl J Med 301: 924–928.

    Article  CAS  Google Scholar 

  3. Kim H, Zelman RJ, Fox MA et al. (1982). Pathology panel for lymphoma clinical studies: A comprehensive analysis of cases accumulated since its inception. J Nat Cancer Inst 68: 43–67.

    PubMed  CAS  Google Scholar 

  4. Lennert K (1978). Malignant lymphomas other than Hodgkin’s disease. In: Handbuch der speziellen pathologischen Anatomie and Histologie, Berlin, Heidelberg, I Band, Teil 3B. New York: Springer-Verlag.

    Google Scholar 

  5. Lukes RJ, Taylor CR, Chir B et al (1978). A morphological and immunological surface marker study of 299 cases of non-Hodgkin lymphomas and related leukemias. Amer J Pathol 90: 461–485.

    CAS  Google Scholar 

  6. Silvestrini R, Piazza R, Riccardi A and Rilke F (1977). Correlation of cell kinetic findings with morphology of non-Hodgkin’s malignant lymphomas. J Nat Cancer Inst 58: 499–504.

    PubMed  CAS  Google Scholar 

  7. Costa A, Bonadonna G, Villa E et al. (1981). Labeling index as a prognostic marker in non-Hodgkin’s lymphoma. J Nat Cancer Inst 66: 1–5.

    PubMed  CAS  Google Scholar 

  8. Lang W, Kienzle B and Diehl V (1980). Proliferation kinetics of malignant non-Hodgkin’s lymphomas related to histopathology of lymph node biopsies. Virchows Arch A Path Anat Histol 389: 397–407.

    Article  CAS  Google Scholar 

  9. Kvalöy S, Godal T, Marton PF et al (1981). Spontaneous (H-3)-Thymidine uptake in histological subgroups of human B-cell lymphomas. Scand J Haematol 26: 221–234.

    Article  PubMed  Google Scholar 

  10. Scarffe JH and Crowther D (1981). The pre-treatment proliferative activity of non-Hodgkin’s lymphoma cells. Europ J Cancer 17: 99–108.

    Article  CAS  Google Scholar 

  11. Diamond LW and Braylan RC (1980). Flow analysis of DNA content and cell size in non-Hodgkin’s lymphoma. Cancer Res 40: 703–712.

    PubMed  CAS  Google Scholar 

  12. Diamond LW, Braylan RC, Bearman RM et al (1980). The determination of cellular content in neoplastic and non-neoplastic lymphoid populations by flow cytofluorometry. Flow Cytometry IV: 478–482.

    Google Scholar 

  13. Diamond LW, Nathwani BN and Rappaport H (1982). Flow cytometry in the diagnosis and classification of malignant lymphoma and leukemia. Cancer 50: 1122–1135.

    Article  PubMed  CAS  Google Scholar 

  14. Barlogie B, Latreille J, Freireich EJ et al. (1980). Characterisation of hematologic malignancies by flow cytometry. Blood cells 6: 719–744.

    PubMed  CAS  Google Scholar 

  15. Braylan RC, Fowlkes BJ, Jaffe ES et al. (1978). Cell volumes and DNA distributions of normal and neoplastic cells. Cancer 41: 201–209.

    Article  PubMed  CAS  Google Scholar 

  16. Kruth HS, Braylan RC, Benson NA and Nourse VA (1981). Simultaneous analysis of DNA and cell surface immunoglogulin in human B-cell lymphomas by flow cytometry. Cancer Res 41: 4895–4899.

    PubMed  CAS  Google Scholar 

  17. Barlogie B, Hittelman W, Spitzer G et al. (1977). Correlation of DNA distribution abnormalities with cytogenetic findings in human adult leukemia and lymphoma. Cancer Res 37: 4400–4407.

    PubMed  CAS  Google Scholar 

  18. Yunis J, Oken M, Kaplan ME et al. (1982). Distinctive chromosomal abnormalities in histologic subtypes of non-Hodgkin’s lymphoma. N Engl J Med 307: 1231–1236.

    Article  PubMed  CAS  Google Scholar 

  19. Bloomfield CD, Rowley JD, Goldman AI et al (1983). Chromosomal abnormalities and their clinical significance in acute lymphoblastic leukemia. Cancer Res 43: 868–873.

    Google Scholar 

  20. Morita M, Minowada J and Sandberg AA (1981). Chromosomes and causation of human cancer and leukemia. XLV. Chromosome patterns in stimulated lymphocytes of chronic lymphocytic leukemia. Cancer Genet Cytogenet 3: 293–306.

    Article  PubMed  CAS  Google Scholar 

  21. Bunn Jr PA, Whang-Peng J, Carney DN et al. (1980). DNA content analysis by flow cytofluorometry and cytogenetic analysis in mycosis fungoides and Sezary syndrome. J Clin Invest 65: 1440–1448.

    Article  PubMed  Google Scholar 

  22. Mason DY and Biberfeld P (1980). Technical aspects of lymphoma immunohistology. J Histochem Cytochem 28: 731–745.

    Article  PubMed  CAS  Google Scholar 

  23. Gerard-Marchant R, Hamlin I, Lennert K et al. (1974). Classification of non-Hodgkin’s lymphomas. Lancet II: 406–408.

    Google Scholar 

  24. Christensson B, Lindemalm C, Johansson B et al. (1983). Correlation of immunophenotype to morphology in unfavourable non-Hodgkin’s lymphoma. Acta Path Microbiol Immunol Scand sect A 91: 425–433.

    CAS  Google Scholar 

  25. Porwit- Ksiazek A, Christensson B., Lindemalm C et al (1983). Characterisation of malignant and non-neoplastic cell phenotypes in highly malignant non-Hodgkin lymphomas. Int J Cancer 32: 667–674.

    Article  PubMed  CAS  Google Scholar 

  26. Tribukait B (1984). Flow cytometry in surgical pathology and cytology of tumors from the genito-urinary tract. In: Koss G, Coleman DV (Eds.). Adv. Clin Cytol Vol. 2: 163–198.

    Google Scholar 

  27. Baisch H, Göhde W and Linden WA (1975). Analysis of PCP-data to determine the fraction of cells in various phases of the cell cycle. Radiat Environ Biophys 12: 31–39.

    Article  PubMed  CAS  Google Scholar 

  28. Klecka WR (1981). Discriminant Analysis. In: SPSS second edition, pp. 434–467. New York: McGraw-Hill.

    Google Scholar 

  29. Lindemalm C, Christensson B, Johansson B et al. (1983). A clinico-pathological and immunological study of unfavourable non-Hodgkin lymphomas: Comparison of the Rappaport and Kiel classifications. Acta Path Microbiol Immunol Scand sect A 91: 435–443.

    CAS  Google Scholar 

  30. Taylor IW and Milthorpe BK (1980). An evaluation of DNA fluorochromes, staining techniques, and analysis for flow cytometry. I. Unperturbed cell populations. J Histochem Cytochem 28: 1224–1232.

    Article  PubMed  CAS  Google Scholar 

  31. Shackney SE, Skramstad KS, Cunningham RE et al. (1980). Dual parameter flow cytometry studies in human lymphomas. J Clin Invest 66: 1281–1294.

    Article  PubMed  CAS  Google Scholar 

  32. Barlogie B, Raber M, Schumann J et al. (1983). Flow cytometry in clinical research. Cancer Res 43: 3982–3997.

    PubMed  CAS  Google Scholar 

  33. Look AT, Melvin SL, Williams DL et al (1982). Aneuploidy and percentage of S-phase cells determined by flow cytometry correlate with cell phenotype in childhood leukemia. Blood 60: 959–963.

    PubMed  CAS  Google Scholar 

  34. Neel BG, Jhanwar SC, Chaganti RS and Hayward WS (1982). Two human c-onc genes are located on the long arm of chromosome 8. Proc Nat Acad Sci USA 79: 7842–7846.

    Article  PubMed  CAS  Google Scholar 

  35. Taub R, Kirsch I, Morton C et al (1982). Translocation of the C-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells. Proc Nat Acad Sci USA 79: 7837–7841.

    Article  PubMed  CAS  Google Scholar 

  36. Dalla-Favera R, Bregni M, Erikson J et al. (1982). Human C-MYC ONC gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells. Proc Nat Acad Sci USA 79: 7824–7827.

    Article  PubMed  CAS  Google Scholar 

  37. Hansen H, Koziner B and Clarkson B (1981). Marker and kinetic studies in the non-Hodgkin’s lymphomas Amer J Med 71: 107–123.

    CAS  Google Scholar 

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© 1985 Martinus Nijhoff Publishers, Boston

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Christensson, B., Tribukait, B., Biberfeld, P. (1985). DNA content and proliferation in non-Hodgkin’s lymphoma: Flow cytofluorometric DNA analysis in relation to the Kiel classification. In: Cavalli, F., Bonadonna, G., Rozencweig, M. (eds) Malignant Lymphomas and Hodgkin’s Disease: Experimental and Therapeutic Advances. Developments in Oncology, vol 32. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2607-6_11

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  • DOI: https://doi.org/10.1007/978-1-4613-2607-6_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9632-4

  • Online ISBN: 978-1-4613-2607-6

  • eBook Packages: Springer Book Archive

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