Abstract
Specific association of non-random chromosomal rearrangements with distinct malignancies is now widely recognized. At the Sixth Human Gene Mapping Workshop in 1981, the best known associations of this type were assembled for publication as a committee report [1]. A greatly enlarged compilation of similar data has appeared as a result of the Seventh Human Gene Mapping Workshop held in 1983 [2]. As many as 54 recurrent associations between a break point and a neoplastic disorder were recorded. The number of disorders involved was 30. During the last year, several new associations of this type have been found. It is becoming increasingly clear that many of these are specifically related to the rearrangement, transcriptional activation, or amplification of cellular oncogenes located close to the breakpoints.
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References
Berger R, Bernheim A and de la Chapelle A (1982). Chromosome rearrangements in acquired malignant diseases. Cytogenet Cell Genet 32: 205–207.
de la Chapelle A and Berger R (1984). Report of the committee on chromosome rearrangements in neoplasia and on fragile sites. Cytogenet Cell Genet 37: 274–311.
Manolov G and Manolova Y (1972). Marker band in one chromosome 14 from Burkitt lymphomas. Nature 237: 33–34.
Zech L, Haglund U, Nilsson K and Klein G (1976). Characteristic chromosomal abnormalities in biopsies and lymphoid cell lines from patients with Burkitt and non-Burkitt lymphomas. Int J Cancer 17: 47–56.
Zech L (1983). Chromosome abnormalities in malignant diseases of the lymphatic system, pp. 269–295. In: Molander DW (Ed.). Diseases of the Lymphatic System. New York: Springer-Verlag.
Klein G (1981). The role of gene dosage and genetic transpositions in carcinogenesis. Nature 294: 313–318.
Perry RP (1983). Consequences of myc invasion of immunoglobulin loci: Facts and speculation. Cell 33: 647–649.
Nowell P. Dalla-Favera R, Finan J et al. (1983). Chromosome translocations, immunoglobulin genes, and neoplasia, pp. 165–182. In: Rowley JD and Ultmann JE (Eds.). Chromosomes and Cancer. New York: Academic Press.
Cory S. C-myc oncogene activation by chromosome translocation in mouse and man. In: Andersson LC, Ekblom P, Gahmberg CG and Klein G (Eds.). Gene Expression During Normal and Malignant Differentiation. Academic Press (in press).
Klein G. Oncogene activation by chromosomal translocations. In: Andersson LC, Ekblom P, Gahmberg CG and Klein G (Eds). Gene Expression During Normal and Malignant Differentiation. Academic Press (in press).
Bigger RJ, Lee EC, Nkrumah Fk and Whang-Peng J (1981). Direct cytogenetic studies by needle aspiration of Burkitt’s lymphoma in Ghana West Africa. J Nat Cancer Inst 67: 769–776.
Douglass EC, Magrath IT, Lee EC and Whang-Peng J (1980). Cytogenetic studies in non-African Burkitt lymphoma. Blood 55: 148–155.
Berger R and Bernheim A (1982). Cytogenetic studies on Burkitt’s lymphoma-leukemia. Cancer Genet Cytogenet 7: 231–244.
Knuutila S, Elonen E, Heinonen K et al. (1984). Chromosome abnormalities in 16 Finnish patients with Burkitt’s lymphoma or L3 acute lymphocytic leukemia. Cancer Genet Cytogenet 13: 139–151.
ISCN (1978). Birth Defects Original Article Series, Vol. 14, No. 8. New York: The National Foundation.
Second International Workshop on Chromosomes in Leukemia (1980). General Report. Cancer Genet Cytogenet 2: 93–96.
Lenoir GM, Preud’homme JL, Bernheim A and Berger R (1982). Correlation between immunoglobulin light chain expression and variant translocation in Burkitt’s lymphoma. Nature 298: 474–476.
Brito-Babapulle V and Atkin NB (1981). Break points in chromosome no. 1 abnormalities of 218 human neoplasms. Cancer Genet Cytogenet 4: 215–225.
Fourth International Workshop on Chromosomes in Leukemia (1984). Cancer Genet Cytogenet 11: 249–360.
Bloomfield CD, Arthur DC, Frizzer G et al. (1983). Nonrandom chromosome abnormalities in lymphoma. Cancer Res 43: 2975–2984.
Yunis JJ, Oken MM, Kaplan ME et al. (1982). Distinctive chromosomal abnormalities in histologic subtypes of non-Hodgkin’s lymphoma. N Engl J Med 307: 1231–1236.
Mitelman F (1983). Catalogue of chromosome aberrations in cancer. Cytogenet Cell Genet 36: 1–516.
Gahrton G, Robert K-H. Friberg K et al. (1980). Nonrandon chromosomal aberrations in chronic lymphocytic leukemia revealed by polyclonal B-cell-mitogen stimulation. Blood 56: 640–647.
Douglass EC, Magrath IT, Lee EC and Whang-Peng J (1980). Serial cytogenetic studies of nonendemic Burkitt’s lymphoma cell lines. J Nat Cancer Inst 65: 891–895.
de la Chapelle A, Lenoir G, Boué J et al. (1983) Lambda Ig constant region genes are translocated to chromosome 8 in Burkitt’s lymphoma with t(8; 22). Nucl Acids Res 11: 1133–1142.
Zhang S, Zech L and Klein G (1982). High-resolution analysis of chromosome markers in Burkitt lymphoma cell Lines. Int J Cancer 29: 153–157.
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© 1985 Martinus Nijhoff Publishers, Boston
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De La Chapelle, A. (1985). Chromosome abnormalities in Burkitt lymphoma and Burkitt-type acute lymphoblastic leukemia. In: Cavalli, F., Bonadonna, G., Rozencweig, M. (eds) Malignant Lymphomas and Hodgkin’s Disease: Experimental and Therapeutic Advances. Developments in Oncology, vol 32. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2607-6_10
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DOI: https://doi.org/10.1007/978-1-4613-2607-6_10
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