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Arachidonic Acid Metabolism and Tumor Promotion

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Arachidonic Acid Metabolism and Tumor Promotion

Part of the book series: Prostaglandins, Leukotrienes, and Cancer ((PLAC,volume 3))

Abstract

Experimental chemical carcinogenesis studies in animals are valuable in identifying those biological events or agents that play either an essential or modulatory role in the development of neoplasias. Mouse skin has proved to be one of the best model systems for studying the multistage nature of carcinogenesis (1–3). Skin tumors in mice can be readily induced by the sequential application of a subthreshold dose of a carcinogen (initiation stage) followed by repetititive treatment with a noncarcinogenic tumor promoter (promotion stage). The initiation stage requires only a single application of either a directacting carcinogen or a procarcinogen which requires metabolism before becoming active; it is of an essentially irreversible nature, while the promotion stage is thought to be initially reversible but later becoming irreversible. This second stage, promotion, is most often accomplished by using the phorbol diester 12-0-tetradecanoyl phorbol 13-acetate (TPA), although a variety of agents have been identified as skin tumor promoters, including benzoyl peroxide, anthralin and dihydroteleocidin B (4). In the SENCAR mouse, promotion has been further subdivided into additional stages in which the sequential use of incomplete or partial promoters such as the ionophore A-23187 and mezerein can replace the use of a complete promoter such as TPA (3,5).

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  1. University of Texas System Cancer Center, Smithville, TX, 78957, USA

    Susan M. Fischer

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  1. The University of Texas System Cancer Center, Smithville, Texas, USA

    Susan M. Fischer  & Thomas J. Slaga  & 

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© 1985 Martinus Nijhoff Publishing, Boston

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Fischer, S.M. (1985). Arachidonic Acid Metabolism and Tumor Promotion. In: Fischer, S.M., Slaga, T.J. (eds) Arachidonic Acid Metabolism and Tumor Promotion. Prostaglandins, Leukotrienes, and Cancer, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2605-2_3

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  • DOI: https://doi.org/10.1007/978-1-4613-2605-2_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9631-7

  • Online ISBN: 978-1-4613-2605-2

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