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Arachidonic Acid Metabolism in the Skin

  • Vincent A. Ziboh
Part of the Prostaglandins, Leukotrienes, and Cancer book series (PLAC, volume 3)

Abstract

The prostaglandins and related arachidonate metabolites are not normally synthesized or stored to any extent in body tissues. Increased levels are brought about by rapid biosynthesis in response to a variety of chemical, physical and hormonal factors. This synthesis or arachldonlc acid cascade is complex and includes several enzymes that are affected by endogenous and/or exogenous regulatory factors. Generally, molecular oxygen is inserted into a polyunsaturated fatty acid with acyl chain rearrangement to form the various structures. The principle end products of the various branches of the pathway are the prostaglandins, the thromboxanes, prostacyclin, the hydroperoxy and hydroxyfatty acids, and the leukotrlenes. All are derived from the essential fatty acids in the diet.

Keywords

Arachidonic Acid Essential Fatty Acid Arachidonic Acid Metabolism Hairless Mouse Psoriatic Plaque 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Martinus Nijhoff Publishing, Boston 1985

Authors and Affiliations

  • Vincent A. Ziboh
    • 1
  1. 1.University of CaliforniaDavisUSA

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