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Control of Antibody and Autoantibody Production by Prostaglandin E

  • Chapter
Prostaglandins and Immunity

Part of the book series: Prostaglandins, Leukotrienes, and Cancer ((PLAC,volume 4))

Abstract

In this chapter, we will focus on the effects of prostaglandin E2 (PGE2) on humoral immune responses. Results obtained by different authors are often contradictory, making this area confusing but at the same time very exciting. We have studied the influence of PGE2 on in vitro polyclonal immunoglobulin and rheumatoid factor (RF) production by peripheral blood lymphocytes stimulated with pokeweed mitogen (PWM) and the effects of prostaglandin synthesis inhibition in vivo on serum RF concentrations. Our results indicate that endogenous PGE2 (produced by monocytes and macrophages) enhances polyclonal immunoglobulin and auto-antibody production through an inhibitory effect on suppressor T cells. In addition to a detailed discussion of our own findings, we will give a survey of the results obtained by other researchers.

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References

  1. Ceuppens J, Goodwin JS: Endogenous prostaglandin E enhances polyclonal immunoglobulin production by tonically inhibiting T suppressor cell activity. Cell Immunol (70): 41–54, 1982.

    CAS  Google Scholar 

  2. Reinherz EL, Schlossman SF: Regulation of the immune response: inducer and suppressor T-lymphocyte subsets in human beings. N Engl J Med (303): 370–373, 1980.

    Article  PubMed  CAS  Google Scholar 

  3. Thomas Y, Rogozinski L, Irigoyen O, Friedman SM, Kung PC, Goldstein G, Chess L: Functional analysis of human T cell subsets defined by monoclonal antibodies. IV. Induction of suppressor cells-within the OKT4(+) population. J Exp Med (154): 459–467, 1981.

    Article  PubMed  CAS  Google Scholar 

  4. Hallgren HM, Yunis EJ: Suppressor lymphocytes in young and aged humans. J Immunol (118): 1004–1009, 1977.

    Google Scholar 

  5. Kishimoto S, Tomino S, Mitsuya H, Fujiwara H: Age-related changes in suppressor cell functions of human T-cells. J Immunol (123): 1586–1591, 1979.

    PubMed  CAS  Google Scholar 

  6. Goodwin JS, Messner RP: Sensitivity of lymphocytes to prostaglandin E2 increases in subjects over 70 years of age. J Clin Invest (64): 434–439, 1979.

    Article  PubMed  CAS  Google Scholar 

  7. Ceuppens JL, Goodwin JS: Non-steroidal anti-inflammatory agents inhibit the synthesis of IgM rheumatoid factor in vitro. Lancet (1): 528–533, 1982.

    Article  PubMed  CAS  Google Scholar 

  8. Rodriguez MA, Ceuppens JL, Goodwin JS: Regulation of IgM rheumatoid factor production in lymphocyte cultures from young and old subjects. J Immunol (128): 2422–2428, 1982.

    PubMed  CAS  Google Scholar 

  9. Goodwin JS, Ceuppens JL, Rodriguez MA: Effect of nonsteroidal anti-inflammatory agents on immunologic function in patients with rheumatoid arthritis. JAMA (250): 2485–2488, 1983.

    Article  PubMed  CAS  Google Scholar 

  10. Panayi GS, Staite ND, Unger A: Indomethacin inhibits in vitro immunoglobulin production by human B lymphocytes. Agents Actions (11): 608–610, 1981.

    Article  PubMed  CAS  Google Scholar 

  11. Lydyard PM, Brostoff J, Hudspith B, Parry H: Prostaglandin E2-mediated enhancement of human plasma cell differentiation. Immunol Lett (4): 113–116, 1982.

    Article  PubMed  CAS  Google Scholar 

  12. Staite ND, Panayi GS: Regulation of human immunoglobulin production in vitro by prostaglandin E2. Clin Exp Immunol (49): 115–122, 1982.

    PubMed  CAS  Google Scholar 

  13. Gerblich AA, Stavitsky AB: Regulation of the in vitro anamnestic antibody response by cAMP. IV. Evidence for participation of prostaglandins of the E series in the early events. Cell Immunol (48): 318–328, 1979.

    CAS  Google Scholar 

  14. Cook R: Regulation of the in vitro anamnestic antibody response by cyclic AMP. U. Prostaglandins of the E series. Cell Immunol (40): 128–133, 1978.

    Article  CAS  Google Scholar 

  15. Wieder KJ, Webb DR: The effect of prostaglandin metabolism on immunoglobulin and antibody production in naive and educated whole spleen cells. Prost Med (7): 79–90, 1981.

    Article  CAS  Google Scholar 

  16. Webb DR, Nowowiejski I: The role of prostaglandins in the control of the primary immune response to SRBC. Cell Immunol (33): 1–10, 1977.

    Article  PubMed  CAS  Google Scholar 

  17. Mattingly JA, Kemp JD: Suppression of secondary plaque-forming cell responses by rat splenic adnerent cells; evidence for dependence on prostaglandin production. Cell Immunol (48): 195–201, 1979.

    Article  PubMed  CAS  Google Scholar 

  18. Zimecki M, Webb DR: The regulation of the immune response to T-independent antigens by prostaglandins and B cells. J Immunol (117): 2158–2164, 1976.

    PubMed  CAS  Google Scholar 

  19. Kurland JI, Kincade PW, Moore MAS: Regulation of B lymphocyte clonal proliferation by stimulatory and inhibitory macrophage-derived factors. J Exp Med (146): 1420–1427, 1977.

    Article  PubMed  CAS  Google Scholar 

  20. Wisler RL, Newhouse YG: Inhibition of human B lymphocyte colony responses by endogenous synthetised hydrogen peroxide and prostaglandins. Cell Immunol (69): 34–45, 1982.

    Article  Google Scholar 

  21. Gmelig-Myerling F, Waldmann T: Human B cell activation in vitro: augmentation and suppression by monocytes of the immunoglobulin production induced by various B-cell stimulants. J Immunol (126): 529–536, 1981.

    Google Scholar 

  22. Burchiel SW, Warner NL: Cyclic AMP modulation of Fc receptor expression on a pre-B cell lymphoma. J Immunol (124): 1016–1021, 1980.

    PubMed  CAS  Google Scholar 

  23. Emilie D, Crevon MC, Galanaud P: Prostaglandin E2 regulation of human specific B-cell response: interaction with a monocyte product. Clin Immunol Immunopathol (29): 415–423, 1983.

    Article  PubMed  CAS  Google Scholar 

  24. Delfraissy JF, Garanaud P, Wallon C, Balavoine JF, Dormont J: Abolished in vitro antibody response in elderly: exclusive involvement of prostaglandin-induced T suppressor cells. Clin Immunol Immunopathol (24): 377–385, 1982.

    Article  PubMed  CAS  Google Scholar 

  25. Goodwin JS: Modulation of concanavalin A-induced suppressor cell activation by prostaglandin E2. Cell Immunol (49): 421–425, 1980.

    Article  PubMed  CAS  Google Scholar 

  26. Skoldstam L, Zoschke D, Messner R: Increase in Con A-induced suppressor cell activity after indomethacin treatment. Arthritis Rheum (25): 357–359, 1982.

    Article  PubMed  CAS  Google Scholar 

  27. Skoldstam L, Zoschke D, Messner R: Contrasting effects of prostaglandin E2 and indomethacin in modulating Con A-induced human lymphocyte proliferation and suppressor cell development. Clin Immunol Immunopathol (25): 32–42, 1982.

    Article  PubMed  CAS  Google Scholar 

  28. Badger AM, Griswold DE, Walz DT: Augmentation of concanavalin A-induced immunosuppression by indomethacin. Immunopharmacol (4): 149–162, 1982.

    Article  CAS  Google Scholar 

  29. Hasler F, Bluestein HG, Zvaifler NJ, Epstein LB: Analysis of the defects responsible for the impaired regulation of EBV-induced B cell proliferation by rheumatoid arthritis lymphocytes. U. Role of monocytes and the increased sensitivity of rheumatoid arthritis lymphocytes to prostaglandin E. J Immunol (131): 768–772, 1983.

    CAS  Google Scholar 

  30. Tosato G, Steinberg AD, Blaese RM: Defective EB virus-specific suppressor cell function in rheumatoid arthritis. N Engl J Med (305): 1238–1244, 1981.

    Article  PubMed  CAS  Google Scholar 

  31. Moretta L, Webb DR, Grossi CE, Lydyard PM, Cooper MD: Functional analysis of two human T-cell subpopulations: help and suppression of B-cell responses by T-cell bearing receptors for IgM or IgG. J Exp Med (146): 194–199, 1977.

    Article  Google Scholar 

  32. Goodwin JS, Kaszubowski PA, Williams RC Jr: Cyclic adenosine monophosphate response to prostaglandin E2 in subpopulations of human lymphocytes. J Exp Med (150): 1260–1267, 1979.

    Article  PubMed  CAS  Google Scholar 

  33. Webb DR, Nowowiejski I: Mitogen-induced changes in lymphocyte prostaglandin levels: a signal for the induction of suppressor cell activity. Cell Immunol (41): 72–78, 1978.

    Article  PubMed  CAS  Google Scholar 

  34. Rogers TJ, Nowowiejski I, Webb DR: Partial characterization of a prostaglandin-induced suppressor factor. Cell Immunol (50): 82–89, 1980.

    Article  PubMed  CAS  Google Scholar 

  35. Rogers TJ, Campbell L, Calhoon K, Nowowiejski I, Webb DR: Suppression of B-cell and T-cell responses by the prostaglandin induced T cell derived suppressor (PITS). Cell Immunol (66): 269–276, 1982.

    Article  PubMed  CAS  Google Scholar 

  36. Fisher A, Durandy A, Griscelli C: Role of prostaglandin E2 in the induction of nonspecific T lymphocyte suppressor activity. J Immunol (126): 1452–1455, 1981.

    Google Scholar 

  37. Durandy A, Fisher A, Griscelli C: Dysfunctions of pokeweed mitogen-stimulated T and B lymphocyte responses induced by gammaglobulin therapy. J Clin Invest (67): 867–877, 1981.

    Article  PubMed  CAS  Google Scholar 

  38. Webb DR, Osheroff PL: Antigen stimulation of prostaglandin synthesis and control of immune response. Proc Natl Acad Sci USA (73): 1300–1309, 1976.

    Article  PubMed  CAS  Google Scholar 

  39. Goodwin JS, Selinger DS, Messner RP, Reed WP: Effect of indomethacin in vivo on humoral and cellular immunity in humans. Infect Immun (19): 430–437, 1978.

    PubMed  CAS  Google Scholar 

  40. Garin EH, Richard GA: Prostaglandin synthesis inhibition and primary antibody response in experimental nephrotic syndrome. Clin Immunol Immunopathol (30): 129–133, 1984.

    Article  PubMed  CAS  Google Scholar 

  41. Izui S, Kelley V, McConahey PJ, Dixon FJ: Selective suppression of retroviral gp70-anti-gp70 immune complex formation by prostaglandin El in immune systemic lupus erythematosus. J Exp Med (152): 1645–1658, 1980.

    Article  PubMed  CAS  Google Scholar 

  42. Kelley VE, Izui S, Halushka PV: Effect of Ibuprofen, a fatty acid cyclooxygenase inhibitor, on murine lupus. Clin Immunol Immunopathol (25): 223–231, 1982.

    Article  PubMed  CAS  Google Scholar 

  43. Shimamura T, Hashimoto K, Sasaki S: Feedback suppression of the immune response in vivo. II. Involvement of prostaglandins in the generation of suppressor-inducer B lymphocytes. Cell Immunol (69): 192–195, 1982.

    Article  PubMed  CAS  Google Scholar 

  44. Robinson DR, Levine L: Prostaglandin concentrations in synovial fluid in rheumatic diseases: action of indomethacin and aspirine. In: Robinson HJ, Vane JR (eds): Prostaglandin synthetase inhibitors. Raven Press, New York, 1975, pp 223–228

    Google Scholar 

  45. Catanzaro A: Suppressor cells in coccidiomycosis. Cell Immunol (64): 235–245, 1981.

    Article  PubMed  CAS  Google Scholar 

  46. Wolinsky S, Goodwin JS, Messner RP, Williams RC Jr: Role of prostaglandin in the depressed cell-mediated immune response in rheumatoid arthritis. Clin Immunol Immunopathol (17): 31–36, 1980.

    Article  PubMed  CAS  Google Scholar 

  47. Seitz M, Deimann W, Gram N, Huntstein W, Gemsa D: Character- ization of blood mononuclear cells of rheumatoid arthritis patients. Clin Immunol Immunopathol (25): 405–416, 1982.

    Article  PubMed  CAS  Google Scholar 

  48. Scott PA, Farrell JP: Experimental cutaneous leishmaniasis. J Immunol (127): 2395–2400, 1981.

    PubMed  CAS  Google Scholar 

  49. Kleinhenz ME, Ellner J, Spagnuolo PJ, Daniel TM: Suppression of lymphocyte responses by tuberculous plasma and mycobacterial arabinogalactan. J Clin Invest (68): 153–162, 1981.

    Article  PubMed  CAS  Google Scholar 

  50. Kierszenbaum F: Immunologic deficiency during experimental Chagas’ disease (trypanosoma cruzi infection). J Immunol (129): 2202–2205, 1982.

    PubMed  CAS  Google Scholar 

  51. Piessens WF, Partono F, Hoffman SL, Ratiwayanto S, Piessens PW, Palmieri JR, Koiman I, Dennis DT, Carney WP: Antigen-specific suppressor T lymphocytes in human lymphatic filariasis. N Engl J Med (307): 144–148, 1982.

    Article  PubMed  CAS  Google Scholar 

  52. Goodwin JS, DeHoratius R, Israel H, Peake GT, Messner RP: Suppressor cell function in sarcoidosis. Ann Intern Med (90): 169–175, 1979.

    PubMed  CAS  Google Scholar 

  53. Goodwin JS, Messner RP, Bankhurst AD, Peake GT, Saiki JH, Wiliams RC Jr: Prostaglandin-producing suppressor cells in Hodgkin’s disease. N Engl J Med (197): 263–269, 1977.

    Google Scholar 

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Authors
  1. Jan L. Ceuppens
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  2. James S. Goodwin
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Editors and Affiliations

  1. Division of Gerontology, Department of Medicine, University of New Mexico School of Medicine, Albuquerque, NM, 87131, USA

    J. S. Goodwin

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© 1985 Martinus Nijhoff Publishing, Boston

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Ceuppens, J.L., Goodwin, J.S. (1985). Control of Antibody and Autoantibody Production by Prostaglandin E. In: Goodwin, J.S. (eds) Prostaglandins and Immunity. Prostaglandins, Leukotrienes, and Cancer, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2603-8_5

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  • DOI: https://doi.org/10.1007/978-1-4613-2603-8_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9630-0

  • Online ISBN: 978-1-4613-2603-8

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