Skip to main content

The Role of Arachidonic Acid Metabolites in the Function of Murine Suppressor Cells

  • Chapter
Prostaglandins and Immunity

Part of the book series: Prostaglandins, Leukotrienes, and Cancer ((PLAC,volume 4))

Abstract

A great deal of attention has recently been focused on the role of the products of arachidonic acid metabolism in the regulation of the immune response. It has been suggested by numerous investigators, and in a variety of experimental systems, that several arachidonic acid metabolites may alter lymphocyte function. The primary focus of this chapter is a review of the suppressive activities of the products of arachidonic acid metabolism, with particular emphasis on their role in regulatory (suppressor) cell function.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Webb DR, Nowowiejski I, Healy C, Rogers TJ: Immunosuppressive properties of leukotriene D4 and E4 in vitro. Biochem Biophys Res Commun (104): 1617–1622, 1982.

    CAS  Google Scholar 

  2. Bailey JM, Bryant RW, Low CE, Pupillo MB, Vanderhock JY: Regulation of T-lymphocyte mitogenesis by the leukocyte product 15-hydroxy-eicosatetraenoic acid (15-HETE). Cell Immunol (67): 112–120, 1982.

    Article  PubMed  CAS  Google Scholar 

  3. Gualde N, Rabinovitch H, Fredon M, Rigaud M: Effects of 15-hydroperoxyeicosatetraenoic acid on human lymphocyte sheep erythrocyte rosette formation and response to concanavalin A associated with HLA system. Eur J Immunol (12): 773–777, 1982.

    Article  PubMed  CAS  Google Scholar 

  4. Payan DG, Goetzl EJ: Specific suppression of human T lymphocyte function by leukotriene B4. J Immunol (131): 551–553, 1983.

    PubMed  CAS  Google Scholar 

  5. Nelson DS: Nonspecific immunoregulation by macrophages and their products. In: Immunobiology of the Macrophage. Academic Press, New York, 1976, pp 235–257.

    Google Scholar 

  6. Waldman SR, Gottlier AA: Macrophage regulation of DNA synthesis in lymphoid cells: Effects of a soluble factor from macrophages. Cell Immunol (9): 142–156, 1973.

    Article  PubMed  CAS  Google Scholar 

  7. Lopatkin DE, Ranney DF: Maintenance of the resting state and potential regulation of the proliferative phase. In: Lucas DO (ed) Regulatory mechanisms in lymphocyte activation. Academic Press, New York, 1977, pp 195–216.

    Google Scholar 

  8. Stobo JD: Immunosuppression in man: Suppression by macrophages can be mediated by interactions with regulatory T cells. J Immunol (119): 918–924, 1977.

    PubMed  CAS  Google Scholar 

  9. Pierce CW, Aune TM: Mechanism of action of soluble immune response suppressor. In Madden J, Mullen P, Chedid L, Sprealico F (ed) Advances in immunopharmacology. Pergammon Press, Oxford, 1981, pp 397–404.

    Google Scholar 

  10. Henney CS, Bourne HR, Lichtenstein LM: The role of cyclic 3’,5’ adenosine monophosphate in the specific cytolytic activity of lymphoyctes. J Immunol (108): 1526–1534, 1972.

    PubMed  CAS  Google Scholar 

  11. Strom TB, Carpenter CB, Garovoy MR, Austen KF, Merrill JP, Kaliner M: The modulating influence of cyclic nucleotides upon lymphocyte-mediated cytotoxicity. J Exp Med (138): 381–391, 1973.

    Article  PubMed  CAS  Google Scholar 

  12. Darrow TL, Tomar RH: Prostaglandin-mediated regulation of the mixed lymphocyte culture and generation of cytotoxic cells. Cell Immunol (56): 172–183, 1980.

    Article  PubMed  CAS  Google Scholar 

  13. Leung KH, Mihich E: Prostaglandin modulation of development of cell-mediated immunity in culture. Nature (288): 597–600, 1980.

    Article  PubMed  CAS  Google Scholar 

  14. Hale AH, Evans DL, Daniel LW: Effect of prostaglandins on elicitation of anti-viral cytolytic activity. Immunol Lett (4): 171–174, 1982.

    Article  PubMed  CAS  Google Scholar 

  15. Ting C-C, Hargrove ME: Activation of natural killer-derived cytotoxic T lymphocytes. I. Regulation by macrophage and prostaglandins. J Immunol (131): 1734–1741, 1983.

    PubMed  CAS  Google Scholar 

  16. Droller MJ, Perlmann P, Schneider MU: Enhancement of natural and antibody-dependent lymphocyte cytotoxicity by drugs which inhibit prostaglandin production by tumor target cells. Cell Immunol (39): 154–164, 1978.

    Article  PubMed  CAS  Google Scholar 

  17. Droller MJ, Schneider MU, Perlmann P: A possible role of prostaglandins in the inhibition of natural and antibody-dependent cell-mediated cytotoxicity against tumor cells. Cell Immunol (39): 165–177, 1978.

    Article  PubMed  CAS  Google Scholar 

  18. Brunda, MJ, Herberman RB, Holden HT: Inhibition of murine natural killer cell activity by prostaglandins. J Immunol (124): 2682–2687, 1980.

    PubMed  CAS  Google Scholar 

  19. Tracey DE, Adkinson NF Jr: Prostaglandin synthesis inhibitors potentiate the BCG-induced augmentation of natural killer cell activity. J Immunol (125) 136–141, 1980.

    PubMed  CAS  Google Scholar 

  20. Goto T, Herberman RB, Maluish A, Strong DM: Cyclic AMP as a mediator of prostaglandin E-induced suppression of human natural killer cell activity. J Immunol (130): 1350–1355, 1983.

    PubMed  CAS  Google Scholar 

  21. Garovoy MR, Strom TB, Kaliner M, Carpenter CB: Antibody-dependent lymphocyte mediated cytotoxicity mechanism and modulation by cyclic nucleotides. Cell Immunol (20): 197–204, 1975.

    Article  PubMed  CAS  Google Scholar 

  22. Wisloff F, Christoffersen T: Role of cyclic nucleotides in human lymphocyte-mediated antibody-dependent cytotoxicity. Int Archs Allergy Appl Immunol (53): 42–49, 1977.

    Article  CAS  Google Scholar 

  23. Rappaport RS, Dodge GR: Prostaglandin E inhibits the production of human interleukin 2. J Exp Med (155): 943–948, 1982.

    CAS  Google Scholar 

  24. Tilden AB, Balch CM: A comparison of PGE2 effects on human suppressor cell function and on interleukin 2 function. J Immunol (129): 2469–2473, 1982.

    PubMed  CAS  Google Scholar 

  25. Walker C, Kristensen F, Bettens F, deWeck AL: Lymphokine regulation of activated (GI) lymphocytes. I. Prostaglandin E2-induced inhibition of interleukin 2 production. J Immunol (130): 1770–1773, 1983.

    PubMed  CAS  Google Scholar 

  26. Gordon D, Bray MA, Morley J: Control of lymphokine secretion by prostaglandins. Nature (262): 401–402, 1976.

    Article  PubMed  CAS  Google Scholar 

  27. Koopman WJ, Gillis MH, David JR: Prevention of MIF activity by agents known to increase cellular cyclic AMP. J Immunol (110): 1609–1613, 1973.

    PubMed  CAS  Google Scholar 

  28. Metzger Z, Hoffeld JT, Oppenheim JJ: Macrophage-mediated suppression. I. Evidence for participation of both hydrogen peroxide and prostaglandins in suppression of murine lymphocyte proliferation. J Immunol (124): 983–988, 1980.

    PubMed  CAS  Google Scholar 

  29. Bourne HR, Lichtenstein LM, Melmon KL, Henney CS, Weinstein Y, Shearer GM: Modulation of inflammation and immunity by cyclic AMP. Science (184): 19–28, 1974.

    Article  PubMed  CAS  Google Scholar 

  30. Parker CW, Sullivan TJ, Wedner HJ: Cyclic AMP and the immune response. In Greengard P, Robinson GA (ed) Advances in cyclic nuceotide research. Raven Press, New York, 1974, pp 1–79.

    Google Scholar 

  31. DeRubertis FR, Zenser T: Activation of murine lymphocytes by cyclic guanosine 3’,5’-monophosphate: Specificity and role in mitogen action. Biochim Biophys Acta (428): 91–103, 1976.

    PubMed  CAS  Google Scholar 

  32. DeRubertis FR, Zenser TV, Adler WH, Hudson T: Role of cyclic adenosine 3’,5’-monophosphate in lymphocyte mitogenesis. J Immunol (113): 151–161, 1974.

    PubMed  CAS  Google Scholar 

  33. Webb DR Jr, Jamieson AT, Nowowiejski I: Control of mitogeninduced transformation: Characterization of a splenic suppressor cell and its mode of action. Cell Immunol (24): 45–57, 1976.

    Article  PubMed  Google Scholar 

  34. Melmon KL, Weinstein Y, Shearer GM, Bourne HR: Leukocyte separation on the basis of their receptors for biogenic amines and prostaglandins: Relation of the receptor to antibody formation. In Braun W, Lichtenstein L, Parker CW (ed) cAMP, cell growth and the immune response. Springer-Verlag New York, New York, 1975, pp 114–134.

    Google Scholar 

  35. Plescia OJ, Smith AH, Grinwich K: Subversion of immune systems by tumor cells and role of prostaglandins. Proc Natl Acad Sci USA (72): 1848–1851, 1975.

    Article  PubMed  CAS  Google Scholar 

  36. Webb DR, Nowowiejski I: The role of prostaglandins in the control of the primary 19S immune response to sRBC. Cell Immunol (33): 1–10, 1977.

    Article  PubMed  CAS  Google Scholar 

  37. Zimecki M, Webb DR: The regulation of the immune response to T-independent antigens by prostaglandins and B cells. J Immunol (117): 2158–2164, 1976.

    PubMed  CAS  Google Scholar 

  38. Loose LD, DiLuzio NR: Effect of prostaglandin E1 on cellular and humoral immune responses. J Reticuloendothel Soc (13): 70–77, 1973.

    PubMed  CAS  Google Scholar 

  39. Wieder KJ, Webb DR: The effect of prostaglandin metabolism on immunoglobulin and antibody production in naive and educated whole spleen cells. Prostagland Med (7): 79–90, 1981.

    Article  CAS  Google Scholar 

  40. Cook RG, Stavitsky AB, Harold WW: Regulation of the in vitro anamnestic antibody response by cyclic AMP. II. Antigen-dependent enhancement by exogenous prostaglandins of the E series. Cell Immunol (40): 128–140, 1978.

    Article  CAS  Google Scholar 

  41. Gerblich AA, Stavitsky AB: Regulation of the in vitro anamnestic antibody response by cyclic AMP. IV. Evidence for participation of prostaglandins of the E series in the early events. Cell Immunol (48): 318–328, 1979.

    CAS  Google Scholar 

  42. Kishimoto T, Ishizaka K: Regulation of the antibody response in vitro. X. Biphasic effect of cyclic AMP on the secondary anti-hapten antibody response to anti-immunoglobulin and enhancing soluble factor. J Immunol (116): 534–541, 1976.

    PubMed  CAS  Google Scholar 

  43. Gery I, Davies P: Immunoregulatory products of macrophages. In Cohen S, Pick E, Oppenheim J (ed) Biology of the lymphokines Academic Press, New York, 1979, pp 347–367.

    Google Scholar 

  44. Barasoain I, Rojo JM, Portolés A: Effect of indomethacin on in vitro T- and B-cell activation and cell-mediated lysis. Immunopharmacology (2): 83–92, 1979.

    Article  PubMed  CAS  Google Scholar 

  45. Razin E, Globerson A, Skutelsky E: Indomethacin modulates plasma membrane-associated properties of macrophages. Prostagland Leukotrien Med (8): 301–310, 1982.

    Article  CAS  Google Scholar 

  46. Atkinson JP, Simchowitz L, Mehta J, Stenson WF: 5,8,11,14Eicosatetraynoic acid (ETYA) inhibits binding of N-formylmethionyl-leucyl-phenylalanine (FLMP) to its receptor on human granulocytes. Immunopharmacology (4): 1–9, 1982.

    Article  PubMed  CAS  Google Scholar 

  47. Fulton AM, Levy JG: The induction of nonspecific T suppressor lymphocytes by prostaglandin El. Cell Immunol (59): 54–60, 1981.

    Article  PubMed  CAS  Google Scholar 

  48. Ciosek CP Jr, Ortel RW, Thanassi NM, Newcombe DS: Indomethacin potentiates PGE1 stimulated cyclic AMP accumulation in human synoviocytes. Nature (251): 148–150, 1974.

    Article  PubMed  CAS  Google Scholar 

  49. Newcombe DS, Thanassi NM, Ciosek CP Jr: Cartilage cyclic nucleotide phosphodiesterase: Inhibition by anti-inflammatory agents. Life Sci (14): 505–519, 1974.

    Article  PubMed  CAS  Google Scholar 

  50. Jesse RL, Franson RC: Modulation of purified phospholipase A2 activity from human platelets by calcium and indomethacin. Biochim Biophys Acta (575): 467–470, 1979.

    PubMed  CAS  Google Scholar 

  51. Forbes IJ, Smith JL: Effects of anti-inflammatory drugs on lymphocytes. The Lancet (Aug. 12): 334–337, 1967.

    Article  Google Scholar 

  52. Siegel MI, McConnell RT, Porter NA, Cuatrecasas, P: Arachidonate metabolism via lipoxygenase and 12L-hydroperoxy5,8,10,14-icosatetraenoic acid peroxidase sensitive to anti-inflammatory drugs. Proc Natl Acad Sci USA (77): 308–312, 1980.

    Article  PubMed  CAS  Google Scholar 

  53. Webb DR, Osheroff PL: Antigen stimulation of prostaglandin synthesis and control of immune responses. Proc Natl Acad Sci USA (73): 1300–1304, 1976.

    Article  PubMed  CAS  Google Scholar 

  54. Webb DR, Nowowiejski I: Mitogen-induced changes in lymphocyte prostaglandin levels: A signal for the induction of suppressor cell activity. Cell Immunol (41): 72–85, 1978.

    Article  PubMed  CAS  Google Scholar 

  55. Schleimer RP, Benjamini E: Effects of prostaglandin synthesis inhibition on the immune response. Immunopharmacology (3): 205–219, 1981.

    Article  PubMed  CAS  Google Scholar 

  56. Barasoain I, Rojo JM, Portolds A: “In vivo” effects of acetylsalicylic acid and two ether derived compounds on primary immune response and lymphoblastic transformation. Immunopharmacology (2): 293–300, 1980.

    Article  PubMed  CAS  Google Scholar 

  57. Humes JL, Bonney RJ, Pelus L, Dahlgren ME, Sadowski SJ, Kuehl FA Jr, Davies P: Macrophages synthesise and release prostaglandins in response to inflammatory stimuli. Nature (269): 149–151, 1977.

    Article  PubMed  CAS  Google Scholar 

  58. Scott WA, Pawlowski NA, Murray HW, Andreach M, Zrike J, Cohn ZA: Regulation of arachidonic acid metabolism by macrophage activation. J Exp Med (155): 1148–1160, 1982.

    Article  PubMed  CAS  Google Scholar 

  59. Bauminger S: Differences in prostaglandin formation between thymocyte subpopulations. Prostaglandins (16): 351–355, 1978.

    Article  PubMed  CAS  Google Scholar 

  60. Gemsa D: Stimulation of prostaglandin E release from macrophages and possible role in the immune response. In Pick E (ed) Lymphokines, vol. 4. Academic Press, New York, 1981, pp 335–375.

    Google Scholar 

  61. Oropeza-Rendon RL, Ernst M, Schade U, Rietschel ETh, Fischer H: Activation of bone marrow-derived macrophages by repeated zymosan phagocytosis leads to enhanced prostaglandin synthesis. Immunobiology (160): 208–216, 1981.

    PubMed  CAS  Google Scholar 

  62. Lapp WS, Mendes M, Kirchner H, Gemsa D: Prostaglandin synthesis by lymphoid tissue of mice experiencing a graft-versus-host reaction: Relationship to immunosuppression. Cell Immunol (50): 271–281, 1980.

    Article  PubMed  CAS  Google Scholar 

  63. Ellner JJ, Spagnuolo PJ: Suppression of antigen and mitogen induced human T lymphocyte DNA synthesis by bacterial lipopolysaccharide: Mediation by monocyte activation and production of prostaglandins. J Immunol (123): 2689–2695, 1979.

    PubMed  CAS  Google Scholar 

  64. Mattingly JA, Eardley DD, Kemp JD, Gershon RK: Induction of suppressor cells in rat spleen: Influence of microbial stimulation. J Immunol (122): 787–790, 1979.

    PubMed  CAS  Google Scholar 

  65. Mattingly JA, Kemp JD: Suppression of secondary plaque-forming cell responses by rat splenic adherent cells: Evidence for dependence on prostaglandin production. Cell Immunol (48): 195–200, 1979.

    Article  PubMed  CAS  Google Scholar 

  66. Kemp J, Louie D, Mattingly J, Bennett J, Higuchi C, Pretell J, Horowitz M, Gershon R: Suppressor cells in vitro: Differential effects of indomethacin and related compounds. J Immunopharmacol (2): 471–489, 1980.

    Article  PubMed  CAS  Google Scholar 

  67. Koga Y, Taniguchi K, Kubo C, Nomoto K: Peritoneal adherent cells inhibit the generation of cytotoxic T lymphocytes with prostaglandin-mediated system. Cell Immunol (66): 195–201, 1982.

    Article  PubMed  CAS  Google Scholar 

  68. Scott WA, Pawlowski NA, Andreach M, Cohn ZA: Resting macrophages produce distinct metabolites from exogenous arachidonic acid. J Exp Med (155): 535–547, 1982.

    Article  PubMed  CAS  Google Scholar 

  69. Folch H, Waksman BH: Regulation of lymphocyte responses in vitro. V. Suppressor activity of adherent and nonadherent rat lymphoid cells. Cell Immunol (9): 12–24, 1973.

    Article  PubMed  CAS  Google Scholar 

  70. Rogers TJ, Nowowiejski I, Webb DR: Partial characterization of a prostaglandin-induced suppressor factor. Cell Immunol (50): 82–93, 1980.

    Article  PubMed  CAS  Google Scholar 

  71. Webb DR, Wieder K, Rogers TJ, Nowowiejski I: Activation of mouse splenic suppressor cells by endogenous prostaglandin. In de Weck A, Kristensen F, Landy M (ed) Biochemical characterization of lymphokines. Academic Press, New York, 1980, pp 499–501.

    Google Scholar 

  72. Webb DR, Rogers TJ, Nowowiejski I: Endogenous prostaglandin synthesis and the control of lymphocyte function. Ann NY Acad Sci (332): 262–270, 1979.

    Article  PubMed  CAS  Google Scholar 

  73. Rogers TJ, Campbell L, Calhoun K, Nowowiejski I, Webb DR: Suppression of B-cell and T-cell responses by the prostaglandin-induced T-cell-derived suppressor (PITS). I. Analysis of the PITS8 factor. Cell Immunol (66): 269–276, 1982.

    Article  PubMed  CAS  Google Scholar 

  74. Rogers TJ, O’Day K: A rapid and highly sensitive method of identifying lymphocyte hybridomas by electrophoresis of glucose-phosphate isomerase isozymes. Anal Biochem (116): 389–392, 1981.

    Article  PubMed  CAS  Google Scholar 

  75. Rogers TJ, O’Day K: Identification and characterization of lymphocyte hybridomas by electrophoresis of glucose-6phosphate isomerase isozymes. In Langone JJ, Van Vunakis H (ed) Methods in enzymology, vol. 92. Immunochemical techniques, Part E monoclonal antibodies and general immunoassay methods. Academic Press, New York, 1983, pp 237–242.

    Google Scholar 

  76. Jandinski J, Cantor H, Tadakuma T, Peavy DC, Pierce CW: Separation of helper T cells from suppressor T cells express-ing different Ly components. I. Polyclonal activation: Suppressor and helper activities are inherent properties of distinct T-cell subclasses. J Exp Med (143): 1382–1390, 1976.

    Article  PubMed  CAS  Google Scholar 

  77. Tadakuma T, Kühner AL, Rich RR, David JR, Pierce CW: Biological expressions of lymphocyte activation. V. Characterization of a soluble immune response suppressor (SIRS) produced by concanavalin A-activated spleen cells. J Immunol (117): 323–330, 1976.

    PubMed  CAS  Google Scholar 

  78. Aune TM, Pierce CW: Mechanism of action of macrophage-derived suppressor factor produced by soluble immune response suppressor-treated macrophages. J Immunol (127): 368–372, 1981.

    PubMed  CAS  Google Scholar 

  79. Goodwin JS: Modulation of conconavalin-A-induced suppressor cell activation by prostaglandin E2. Cell Immunol (49): 421–425, 1980.

    Article  PubMed  CAS  Google Scholar 

  80. Skoldstam L, Zoschke D, Messner R: Contrasting effects of prostaglandin E2 and indomethacin in modulating Con A-induced human lymphocyte proliferation and suppressor cell development. Clin Immunol Immunopathol (25): 32–42, 1982.

    Article  PubMed  CAS  Google Scholar 

  81. Soppi E, Eskola J, Ruuskanen 0: Effects of indomethacin on lymphocyte proliferation, suppressor cell function, and leukocyte migration inhibitory factor (LMIF) production. Immunopharmacology (4): 235–242, 1982.

    Article  PubMed  CAS  Google Scholar 

  82. Badger AM, Griswold DE, Walz DT: Augmentation of concanavalin A-induced immunosuppression by indomethacin. Immunopharmacology (4): 149–162, 1982.

    Article  PubMed  CAS  Google Scholar 

  83. Leung KH, Ehrke MJ, Mihich E: Modification by biological products of the generation of suppressor cells in culture. Immunopharmacology (5): 221–237, 1983.

    Article  PubMed  CAS  Google Scholar 

  84. Orme IM, Shand FL: Inhibitors of prostaglandin synthetase block the generation of suppressor T cells induced by concanavalin A. Int J Immunopharmacol (3): 15–19, 1981.

    Article  PubMed  CAS  Google Scholar 

  85. Orme IM, Shand FL: Concanavalin A-induced alteration of surface marker expression on murine T cells. Int J Immunopharmacol (4): 137–142, 1982.

    Article  PubMed  CAS  Google Scholar 

  86. Fischer A, Durandy A, Griscelli C: Role of prostaglandin E2 in the induction of nonspecific T lymphocyte suppressor activity. J Immunol (126): 1452–1455, 1981.

    PubMed  CAS  Google Scholar 

  87. Donnelly RP, Rogers TJ: Immunosuppression induced by Staphylococcal enterotoxin B. Cell Immunol (72): 166–177, 1982.

    Article  PubMed  CAS  Google Scholar 

  88. Donnelly RP, Rogers TJ: Inhibitors of prostaglandin synthesis block the induction of Staphylococcal enterotoxin B-activated T-suppressor cells. Cell Immunol (81): 61–70, 1983.

    Article  PubMed  CAS  Google Scholar 

  89. Yamamoto I, Webb DR: Antigen-stimulated changes in cyclic nucleotide levels in the mouse. Proc Natl Acad Sci USA (72): 2320–2324, 1975.

    Article  PubMed  CAS  Google Scholar 

  90. Winchurch RA, Hilberg C, Birmingham N, Munster AM: Lipopolysaccharide-induced activation of suppressor cells: Reversal by an agent which alters cyclic nucleotide metabolism. Immunology (45): 147–153, 1982.

    PubMed  CAS  Google Scholar 

  91. Persson U: Lipopolysaccharide-induced suppression of the primary immune response to a thymus-dependent antigen. J Immunol (118): 789–796, 1977.

    PubMed  CAS  Google Scholar 

  92. Koenig S, Hoffman MK: Bacterial lipopolysaccharide activates suppressor B lymphocytes. Proc Natl Acad Sci USA (76): 4608–4612, 1979.

    Article  PubMed  CAS  Google Scholar 

  93. Vallera DA, Gamble CE, Schmidtke JR: Lipopolysaccharideinduced immunomodulation of the generation cell-mediated cytotoxicity. II. Evidence for the involvement of a regulatory B lymphocyte. J Immunol (124): 641–649, 1980.

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Martinus Nijhoff Publishing, Boston

About this chapter

Cite this chapter

Rogers, T.J. (1985). The Role of Arachidonic Acid Metabolites in the Function of Murine Suppressor Cells. In: Goodwin, J.S. (eds) Prostaglandins and Immunity. Prostaglandins, Leukotrienes, and Cancer, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2603-8_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2603-8_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9630-0

  • Online ISBN: 978-1-4613-2603-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics