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Cardiac Valve Replacement pp 145–153Cite as

Thromboembolism in Children with ST. JUDE MEDICAL® Valves Maintained on Aspirin and PERSANTINE®

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Abstract

Twenty-five consecutive pediatric patients underwent the insertion of 27 ST. JUDE MEDICAL® valves in a nonrandomized clinical trial. All were managed with aspirin and PERSANTINE® postoperatively. Five thromboembolic events (TE) were observed in the 25 patients during a total of 199 patient-months of follow-up. This represents a 20% TE incidence and extrapolates to 30.1 TE events per 100 patient-years. Based on these data, all children are now placed on COUMADIN® therapy. We recommend COUMADIN anticoagulation in all children with the ST. JUDE MEDICAL valve and suggest a cooperative multicenter trial to help resolve the issue.

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Authors
  1. Stuart L. Boe
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  2. Kathleen W. Mcnicholas
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  3. Henry F. Olivier
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  4. Faustino N. Niguidula
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  5. George J. Magovern
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  6. Gerald M. Lemole
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Editor information

Editors and Affiliations

  1. Cedars Sinai Medical Center, 8700 Beverly Blvd., 90048, Los Angeles, CA, USA

    Jack M. Matloff M.D.

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© 1985 Martinus Nijhoff Publishing, Boston

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Boe, S.L., Mcnicholas, K.W., Olivier, H.F., Niguidula, F.N., Magovern, G.J., Lemole, G.M. (1985). Thromboembolism in Children with ST. JUDE MEDICAL® Valves Maintained on Aspirin and PERSANTINE® . In: Matloff, J.M. (eds) Cardiac Valve Replacement. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2601-4_18

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  • DOI: https://doi.org/10.1007/978-1-4613-2601-4_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9629-4

  • Online ISBN: 978-1-4613-2601-4

  • eBook Packages: Springer Book Archive

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