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Pressure Overload: Human Studies

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The Ventricle

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Abstract

When a pressure overload is placed on the myocardium, systolic wall stress is initially increased. The increased load, through an unknown mechanism, is a stimulus to the laying down of sarcomeres in parallel, producing concentric hypertrophy. The resulting increased wall thickness “absorbs” the increase in pressure and helps reestablish wall stress at a normal level [1, 2]. Since afterload is a key determinant of ejection performance of the ventricle, this compensation is adaptive, because by normalizing stress, ventricular ejection performance is maintained. However, when the pressure overload is severe and prolonged, muscle dysfunction may occur. Thus, pressure-overload concentric hypertrophy may be either compensatory or pathologic, depending on the clinical situation. The following is a synopsis of current knowledge regarding the effects of pressure overload and hypertrophy on the human left and right ventricles.

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Authors and Affiliations

  1. Section of Cardiology, Temple University Health Sciences Center, 3401 North Broad Street, Philadelphia, Pennsylvania, 19140, USA

    Blase A. Carabello M.D. & William Grossman

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  1. Blase A. Carabello M.D.
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  2. William Grossman
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Editors and Affiliations

  1. New England Medical Center Hospital, Tufts University School of Medicine, Boston, Massachusetts, USA

    Herbert J. Levine M.D. (Chief, Cardiology Division, Professor of Medicine) (Chief, Cardiology Division, Professor of Medicine)

  2. Veterans Administration Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA

    William H. Gaasch M.D. (Chief of Cardiology, Professor of Medicine) (Chief of Cardiology, Professor of Medicine)

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© 1985 Martinus Nijhoff Publishing, Boston

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Carabello, B.A., Grossman, W. (1985). Pressure Overload: Human Studies. In: Levine, H.J., Gaasch, W.H. (eds) The Ventricle. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2599-4_11

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  • DOI: https://doi.org/10.1007/978-1-4613-2599-4_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9628-7

  • Online ISBN: 978-1-4613-2599-4

  • eBook Packages: Springer Book Archive

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