Skip to main content
SpringerLink
Log in

Selenium-Dependent Glutathione Peroxidase and Eicosanoid Production

  • Chapter
Biochemistry of Arachidonic Acid Metabolism

Part of the book series: Prostaglandins, Leukotrienes, and Cancer ((PLAC,volume 1))

Abstract

In 1971, Lands et al. (1) reported that a functioning glutathione peroxidase (GSHPx, EC 1.11.1.9) system inhibited two dioxygenases, prostaglandin (PG) synthase from sheep vesicular glands and soybean lipoxygenase, suggesting that product activation is an important feature in the mechanism for both enzymes. These initial experiments were followed by a series of studies (See Chapters 1 and 2 this book and Ref. 2) which demonstrated the peroxide requirement for activation and maintenance of the catalytic function of PG synthase in vitro. The synthase is inhibited at peroxide concentrations 1 μmole/1 or greater. This property of duality, stimulation at low and inhibition at high concentrations, has led to the hypothesis that “peroxide tone” can regulate the production of eicosanoids, oxygenated metabolites of arachidonic acid (20: 4). The provocative question that arises from these enzymatic studies is “Does GSHPx function as a modulator of dioxygenases by regulating the hydroperoxide level within the cell?” A survey of the literature indicates that evidence is accumulating to support a positive response to this query and it is this evidence which is the subject of this chapter.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Lands WEM, Lee RE, Smith WL: Factors regulating the biosynthesis of various prostaglandins. Ann NY Acad Sci (180): 107–122, 1971.

    Article  PubMed  CAS  Google Scholar 

  2. Warso MA, Lands WEM: Lipid peroxidation in relation to prostacyclin and thromboxane physiology and pathophysiology. Brit Med Bull (39): 277–280, 1983.

    PubMed  CAS  Google Scholar 

  3. Sunde RA, Hoekstra WG: Structure, synthesis and function of glutathione peroxidase. Nutr Rev(38): 265–273, 1980.

    Article  PubMed  CAS  Google Scholar 

  4. Flohe L: Glutathione peroxidase brought into focus. In: Pryor WA(ed) Free radicals in biology Vol V. Academic Press, New York, 1982, pp 223–254.

    Google Scholar 

  5. Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG: Selenium: biochemical role as a component of glutathione peroxidase. Science (179): 588–590, 1973.

    Article  PubMed  CAS  Google Scholar 

  6. Diplock AT: The role of vitamin E and selenium in the prevention of oxygen-induced tissue damage. In: Spallholz JE, Martin JL, Ganther HE(eds) Selenium in biology and medicine. AVI Publishing Co, Westport, CT, 1981, pp 303–316.

    Google Scholar 

  7. Friedberg T, Bentley P, Stasieki P, Glatt HR, Raphael D, Oesch F: The identification, solubilization, and characterization of microsome-associated glutathione S-transferases. J Biol Chem(254): 12028–12033, 1979.

    PubMed  CAS  Google Scholar 

  8. Lawrence RA, Burk RF: Glutathione peroxidase activity in selenium-deficient rat liver. Biochem Biophys Res Commun(71): 952–958, 1976.

    Article  PubMed  CAS  Google Scholar 

  9. Prohaska JR, Ganther HE: Glutathione peroxidase activity of glutathione-S-transferases from rat liver. Biochim Biophys Res Commun(76): 437–445, 1977.

    Article  CAS  Google Scholar 

  10. Sevanian A, Muakkassah-Kelly SF, Montestruque S: The influence of phospholipase A2 and glutathione peroxidase on the elimination of membrane lipid peroxides. Arch Biochem Biophys(223): 441–452, 1983.

    Article  PubMed  CAS  Google Scholar 

  11. Grossmann A, Wendel A: Non-reactivity of the selenoenzyme glutathione peroxidase with enzymatically hydroperoxidized phospholipids. Eur J Biochem(135): 549–552, 1983.

    Article  PubMed  CAS  Google Scholar 

  12. Bryant RW, Bailey JM: Altered lipoxygenase metabolism and decreased glutathione peroxidase activity in platelets from selenium-deficient rats. Biochem Biophys Res Commun(92): 268–276, 1980.

    Article  PubMed  CAS  Google Scholar 

  13. Doni MG, Avventi GL, Bonadiman L, Bonaccorso G: Glutathione peroxidase, selenium, and prostaglandin synthesis in platelets. Am J Physiol(240): H800–H803, 1981.

    PubMed  CAS  Google Scholar 

  14. Levander OA, DeLoach DP, Morris VC, Moser PB: Platelet glutathione peroxidase activity as an index of selenium status in rats. J Nutr(113): 55–63, 1983.

    PubMed  CAS  Google Scholar 

  15. Carmagnol R, Sinet PM, Jerome H: Selenium-dependent and non-selenium-dependent glutathione peroxidases in human tissue extracts. Biochim Biophys Acta(759): 49–57, 1983.

    PubMed  CAS  Google Scholar 

  16. Jakschik BA, Harper T, Murphy RC: Leukotriene C4 and D4 formation by particulate enzymes. J Biol Chem(257).5346–5349, 1982.

    PubMed  CAS  Google Scholar 

  17. Bryant RW, Simon TC, Bailey JM: Role of glutathione peroxidase and hexose monophosphate shunt in the platelet lipoxygenase pathway. J Biol Chem(257): 14937–14943, 1982.

    PubMed  CAS  Google Scholar 

  18. Bryant RW, Simon TC, Bailey JM: Hydroperoxy fatty acid formation in selenium deficient rat platelets: coupling of glutathione peroxidase to the lipoxygenase pathway. Biochem Biophys Res Commun(117): 183–189, 1983.

    Article  PubMed  CAS  Google Scholar 

  19. Yokoyama C, Mizuno K, Mitachi H, Yoshimoto T, Yamanoto S, Pace-Asciak CR: Partial purification and characterization of arachidonate 12-lipoxygenase from rat lung. Biochim Biophys Acta(750): 237–243, 1983.

    PubMed  CAS  Google Scholar 

  20. Egan RW, Tischler AN, Baptista EM, Ham EA, Soderman DD, Gale PH: Specific inhibition and oxidative regulation of 5-lipoxygenase. In: Samuelsson B, Paoletti R, Ramwell, P(eds) Advances in prostaglandin, thromboxane, and leukotriene research Vol 11. Raven Press, New York, 1983, pp 151–157.

    Google Scholar 

  21. Kawaguchi H, Ishibashi T, Imai Y: Increased thromboxane B2 biosynthesis in platelets. Lipids(17): 577–584, 1982.

    Article  PubMed  CAS  Google Scholar 

  22. Masukawa T, Goto J, Iwata H: Impaired metabolism of arachidonate in selenium deficient animals. Experientia(39): 405–406, 1983.

    Article  PubMed  CAS  Google Scholar 

  23. Schoene NW, Morris VC, Levander OA: Effects of selenium deficiency on aggregation and thromboxane formation in rat platelets. Fed Proc(43): 477, 1984.

    Google Scholar 

  24. Doni MG, Bonaccorso G, Piva E: High glutathione peroxidase and prostacyclin-like activity generation in rat aorta. Haemostasis(13): 248–253, 1983.

    PubMed  CAS  Google Scholar 

  25. Moncada S, Vane JR: Arachidonic acid metabolites and the interactions between platelets and blood-vessel walls. N Engl J Med(300): 1142–1147, 1979.

    Article  PubMed  CAS  Google Scholar 

  26. Sautebin L, Caruso D, Galli G, Paoletti R: Preferential utilization of endogenous arachidonate by cyclooxygenase in incubations of human platelets. FEBS Lett(157): 173–178, 1983.

    Article  PubMed  CAS  Google Scholar 

  27. Kent RS, Diedrich SL, Whorton AR: Regulation of vascular prostaglandin synthesis by metabolites of arachidonic acid in perfused rabbit aorta. J Clin Invest(72): 455–465, 1983.

    Article  PubMed  CAS  Google Scholar 

  28. Salmon JA, Smith DR, Flower RJ, Moncada S, Vane JR: Further studies on the enzymatic conversion of prostaglandin endoperoxides into prostacyclin by porcine aorta microsomes. Biochim Biophys Acta(523): 250–262, 1978.

    PubMed  CAS  Google Scholar 

  29. Maclouf J, Fruteau de Laclos B, Borgeat P: Stimulation of leuko-triene biosynthesis in human blood leukocytes by platelet-derived 12-hydroperoxy-icosatetraenoic acid. Proc Natl Acad Sei USA(79): 6042–6046, 1982.

    Article  CAS  Google Scholar 

  30. Marcus AJ, Broekman MJ, Safier LB, Ullman HL, Islam N: Formation of leukotrienes and other hydroxy acids during platelet-neutrophil interactions in vitro. Biochem Biophys Res Commun(109): 130–137, 1982.

    Article  PubMed  CAS  Google Scholar 

  31. Griffin AC: The chemopreventive role of selenium in carcinogenesis. In: Arnott MS, Van Eys J, Wang Y-M(eds) Molecular interrelations of nutrition and cancer. Raven Press, New York, 1982, pp 401–408.

    Google Scholar 

  32. Honn KV, Busse WD, Sloane BF: Prostacyclin and thromboxanes-implications for their role in tumor cell metastasis. Biochem Pharmacol(32): l–ll, 1983.

    Article  Google Scholar 

  33. Ip C, Sinha DK: Enhancement of mammary tumorigenesis by dietary selenium deficiency in rats with a high polyunsaturated fat intake. Cancer Res(41): 31–34, 1981.

    PubMed  CAS  Google Scholar 

  34. IpC: Selenium-mediated inhibition of mammary carcinogenesis. Biol Tr Elem Res(5): 317–330, 1983.

    Article  Google Scholar 

  35. Dutilh CE, Haddeman E, ten Hoor F: Role of the arachidonate lipoxygenase pathway in blood platelet aggregation. In: Samuelsson B, Ramwell PW, Paoletti R(eds) Advances in prostaglandin and thromboxane research Vol 6. Raven Press, New York, 1980, pp 101–105.

    Google Scholar 

  36. Nakao J, Ooyama T, Ito H, Chang WC, Murota ST: Comparative effects of lipoxygenase products of arachidonic acid on rat aortic smooth muscle cells. Atherosclerosis(44): 339–342, 1982.

    Article  PubMed  CAS  Google Scholar 

  37. Fischer SM, Mills GD, Slaga TJ: Inhibition of mouse skin tumor promotion by several inhibitors of arachidonic acid metabolism. Carcinogenesis(3): 1243–1245, 1982.

    Article  PubMed  CAS  Google Scholar 

  38. O’Brien PJ: Peroxide-mediated metabolic activation of carcinogens. In: Yagi K(ed) Lipid peroxides in biology and medicine. Academic Press, New York, 1982, pp 317–338.

    Google Scholar 

  39. Fantone JC, Elgas LJ, Weinberger L, Varani J: Modulation of tumor cell adherence by prostaglandins. Oncology(40): 421–426, 1983.

    Article  PubMed  CAS  Google Scholar 

  40. Hayashi H, Yoshida K, Ozak T, Ushijima K: Chemotactic factor associated with invasion of cancer cells. Nature(226): 174–175, 1970.

    Article  PubMed  CAS  Google Scholar 

  41. Honn KV, Cicone B, Skoff A: Prostacyclin: a potent antimetastatic agent. Science(212): 1270–1272, 1981.

    Article  PubMed  CAS  Google Scholar 

  42. Donati MB, Rotilio D, Delaini F, Giavazze A, Mantovani A, Poggi A: Animal models for the study of platelet-tumor cell interaction. In: Jamieson GJA(ed) Interaction of platelets and tumor cells. Alan R Liss, New York, 1982, pp 159–176.

    Google Scholar 

  43. Karmali RA, Welt S, Thaler HT, Lefevre F: Prostaglandins in breast cancer: relationship to disease stage and hormone status. Br J Cancer(48): 689–696, 1983.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. Norberta W. Schoene
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Biological Chemistry College of Medicine, University of Illinois at Chicago, 1853 W. Polk St., 60612, Chicago, IL, USA

    William E. M. Lands

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Martinus Nijhoff Publishing, Boston

About this chapter

Cite this chapter

Schoene, N.W. (1985). Selenium-Dependent Glutathione Peroxidase and Eicosanoid Production. In: Lands, W.E.M. (eds) Biochemistry of Arachidonic Acid Metabolism. Prostaglandins, Leukotrienes, and Cancer, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2597-0_8

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2597-0_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9627-0

  • Online ISBN: 978-1-4613-2597-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation